Diffusion tensor imaging and tractography of the white matter in normal aging: the rate-of-change differs between segments within tracts
Open accessAbstract
Knowledge concerning the normal aging of cerebral white matter will improve our understanding of abnormal changes in neurodegenerative diseases. The microstructural basis of white matter maturation and aging can be investigated using diffusion tensor imaging (DTI). Generally, diffusion anisotropy increases during childhood and adolescence followed by a decline in middle age. However, this process is subject to spatial variations between tracts. The aim of this study was to investigate to what extent age-related variations also occur within tracts. DTI parameters were compared between segments of two white matter tracts, the cingulate bundle (CB) and the inferior fronto-occipital fasciculus (IFO), in 257 healthy individuals between 13 and 84years of age. Segments of the CB and the IFO were extracted and parameters for each segment were averaged across the hemispheres. The data was analysed as a function of age. Results show that age-related changes differ both between and within individual tracts. Different age trajectories were observed in all segments of the analysed tracts for all DTI parameters. In conclusion, aging does not affect white matter tracts uniformly but is regionally specific; both between and within white matter tracts.
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Some evidence is consistent with an age-related gradient along the long axis of the cingulum, in which frontal parts of the bundle appear most affected.
“Some of the evidence is consistent with an age-related gradient along the long axis of the cingulum, in which frontal parts of the bundle appear most affected (Catheline et al., 2010; Mårtensson et al., 2018; Sibilia et al., 2017; Yoon et al., 2008; see for review Chua et al., 2008).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Mårtensson et al., 2018
The indexed Abstract (no page given) reports that age-related changes differ between segments of the cingulate bundle, supporting variation along the tract. It does not say that frontal segments are the most affected, so the proposed direction of the gradient is not supported by our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measuredIn the posterior cingulum, FA reached a maximum in early adulthood up to the age of 40 and then declined, while RD was lowest at midlife and increased thereafter with age.
“In the posterior cingulum, FA reached a maximum in early adulthood up to the age of 40 and then declined, whilst RD was lowest at midlife and increased thereafter with age.”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Mårtensson et al., 2018
The available passages labelled Abstract contain bibliographic details and keywords, including cingulum and fractional anisotropy, but no results describing their age trajectories. Searches for posterior cingulum, FA, RD, and the age-40 peak found no passage in our copy that verifies the claimed pattern. (LLM, conf=0.70)
Experimental — accuracy not yet measuredIn the anterior portion of the cingulum, RD values increased from the age of 28.
“In the anterior portion of the cingulum, RD values increased from the age of 28.”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Mårtensson et al., 2018
The available indexed passages (labeled Abstract; no page given) identify a paper about aging and the cingulum but do not report RD values or an age at which they began to increase. Searches for anterior cingulum, radial diffusivity, and age 28 found no passage addressing the specific claim. (LLM, conf=0.72)
Experimental — accuracy not yet measuredMårtensson et al. (2018) found age-related FA differences in the anterior and posterior but not the inferior portions of the cingulum, while RD, AD and MD showed also effects in the inferior portion.
“They found age-related FA differences in the anterior and posterior but not in the inferior portions of the cingulum whilst RD, AD and MD showed also effects in the inferior portion.”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Mårtensson et al., 2018
The retrieved passages contain bibliographic information and keywords, but no Results passage reporting FA, RD, AD, or MD by cingulum portion. Searches for anterior, posterior, and inferior cingulum effects did not locate evidence for the claimed pattern in the indexed copy. (LLM, conf=0.70)
Experimental — accuracy not yet measured
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Cites
NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain
Zhang, H., Schneider, T., Wheeler-Kingshott, C. A., & Alexander, D. C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.072 · Cited by 3,288 · see citing works
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The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740 · see citing works
“Some of the evidence is consistent with an age-related gradient along the long axis of the cingulum, in which frontal parts of the bundle appear most affected (Catheline et al., 2010; Mårtensson et al., 2018; Sibilia et al., 2017; Yoon et al., 2008; see for review Chua et al., 2008).”
- Authors
- Mårtensson, J., Lätt, J., Åhs, F., Fredrikson, M., Söderlund, H., Schiöth, H. B., Kok, J., Kremer, B., van Westen, D., Larsson, E.-M., & Nilsson, M.
- Affiliations
- Uppsala University (SE)
- Skåne University Hospital (SE)
- Karolinska Institutet (SE)
- University Medical Center Groningen (NL)
- Lund University (SE)
- Corresponding author
- Mårtensson, J.
- Venue
- Magnetic Resonance Imaging
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 45
- Pages
- 113-119
- ISSN
- 0730-725X (ISSN-L)
- OpenAlex
- W2601282981
- Cited by
- 27
- References
- 3
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 1
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Keywords
- normal aging, white matter, diffusion tensor imaging, tractography, inferior fronto-occipital fasciculus, diffusion anisotropy, age-related changes, white matter maturation, neurodegenerative diseases
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Female, Humans, Male, Middle Aged, Diffusion Magnetic Resonance Imaging, Young Adult, Diffusion Tensor Imaging, White Matter
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