Enhanced mechanical properties of thermosensitive chitosan hydrogel by silk fibers for cartilage tissue engineering

Mirahmadi, Fereshteh; Tafazzoli-Shadpour, Mohammad; Shokrgozar, Mohammad Ali; Bonakdar, Shahin

doi:10.1016/j.msec.2013.07.043

Cited by 232Silk-based biomaterials and applicationsHydrogels: synthesis, properties, applicationsOsteoarthritis Treatment and Mechanisms

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Enhanced mechanical properties of thermosensitive chitosan hydrogel by silk fibers for cartilage tissue engineering

Mirahmadi, Fereshteh, Tafazzoli-Shadpour, Mohammad, Shokrgozar, Mohammad Ali, Bonakdar, Shahin·2013·Materials Science and Engineering C

DOI 10.1016/j.msec.2013.07.043

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Abstract

Articular cartilage has limited repair capability following traumatic injuries and current methods of treatment remain inefficient. Reconstructing cartilage provides a new way for cartilage repair and natural polymers are often used as scaffold because of their biocompatibility and biofunctionality. In this study, we added degummed chopped silk fibers and electrospun silk fibers to the thermosensitive chitosan/glycerophosphate hydrogels to reinforce two hydrogel constructs which were used as scaffold for hyaline cartilage regeneration. The gelation temperature and gelation time of hydrogel were analyzed by the rheometer and vial tilting method. Mechanical characterization was measured by uniaxial compression, indentation and dynamic mechanical analysis assay. Chondrocytes were then harvested from the knee joint of the New Zealand white rabbits and cultured in constructs. The cell proliferation, viability, production of glycosaminoglycans and collagen type II were assessed. The results showed that mechanical properties of the hydrogel were significantly enhanced when a hybrid with two layers of electrospun silk fibers was made. The results of GAG and collagen type II in cell-seeded scaffolds indicate support of the chondrogenic phenotype for chondrocytes with a significant increase in degummed silk fiber-hydrogel composite for GAG content and in two-layer electrospun fiber-hydrogel composite for Col II. It was concluded that these two modified scaffolds could be employed for cartilage tissue engineering.

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The increase in water uptake of Gel-HNT/ZA is related to its larger pore nature, and microstructure can affect swelling ratio.
“This increase can be related to the larger pore nature in the Gel-HNT/ZA scaffold and proved by such studies that the microstructure can affect the swelling ratio (Mirahmadi et al., 2013).”
From Osteogenesis Improvement of Gelatin-Based Nanocomposite Scaffold by Loading Zoledronic Acid (2022) · cites this paper as Mirahmadi et al., 2013
More swelling ratio results in more water adsorption, which is suitable for deeper diffusion of nutrition and better removal of waste from the matrix.
“The more swelling ratio resulted in more water adsorption that is suitable for dipper diffusion of nutrition and better removing of waste from the matrix (Mirahmadi et al., 2013).”
From Osteogenesis Improvement of Gelatin-Based Nanocomposite Scaffold by Loading Zoledronic Acid (2022) · cites this paper as Mirahmadi et al., 2013

Silk as a biomaterial
Vepari, C., & Kaplan, D. L. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.013 · Cited by 2,579
Electrospinning of Polymeric Nanofibers for Tissue Engineering Applications: A Review
Pham, Q. P., Sharma, U., & Mikos, A. G. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.1197 · Cited by 2,259
Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review
Suh, J.-K., & Matthew, H. W. T. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00126-5 · Cited by 1,987
Principles of Tissue Engineering
(2014) · Elsevier eBooks · doi:10.1016/c2011-0-07193-4 · Cited by 1,912
Chitosan and its derivatives for tissue engineering applications
Kim, I.-Y., Seo, S.-J., Moon, H., Yoo, M. K., Park, I.-Y., Kim, B.-C., & Cho, C.-S. (2007) · Biotechnology Advances · doi:10.1016/j.biotechadv.2007.07.009 · Cited by 1,430
Novel injectable neutral solutions of chitosan form biodegradable gels in situ
Chenite, A., Chaput, C., Wang, D., Combes, C., Buschmann, M. D., Hoemann, C. D., Leroux, J., Atkinson, B. L., Binette, F., & Selmani, A. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00116-2 · Cited by 1,410
Review: tissue engineering for regeneration of articular cartilage
Temenoff, J. S., & Mikos, A. G. (2000) · Biomaterials · doi:10.1016/s0142-9612(99)00213-6 · Cited by 1,056
Bacterial cellulose as a potential scaffold for tissue engineering of cartilage
Svensson, A., Nicklasson, E., Harrah, T., Panilaitis, B., Kaplan, D. L., Brittberg, M., & Gatenholm, P. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.02.049 · Cited by 1,027
Biodegradation of Silk Biomaterials
Cao, Y., & Wang, B. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10041514 · Cited by 719
Effect of pore size on ECM secretion and cell growth in gelatin scaffold for articular cartilage tissue engineering
Lien, S.-M., Ko, L.-Y., & Huang, T.-J. (2008) · Acta Biomaterialia · doi:10.1016/j.actbio.2008.09.020 · Cited by 667
Rheological characterisation of thermogelling chitosan/glycerol-phosphate solutions
Chenite, A. (2001) · Carbohydrate Polymers · doi:10.1016/s0144-8617(00)00281-2 · Cited by 552
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Hardy, J. G., Römer, L., & Scheibel, T. (2008) · Polymer · doi:10.1016/j.polymer.2008.08.006 · Cited by 506
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Jin, R., Teixeira, L. M., Dijkstra, P. J., Karperien, M., van Blitterswijk, C., Zhong, Z., & Feijén, J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.020 · Cited by 495
Cartilage tissue engineering with silk scaffolds and human articular chondrocytes
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Eyrich, D., Brandl, F., Appel, B., Wiese, H., Maier, G., Wenzel, M. M., Staudenmaier, R., Göpferich, A. M., & Blunk, T. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.08.027 · Cited by 383
Chitosan scaffolds: Interconnective pore size and cartilage engineering
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Hoemann, C. D., Hurtig, M., Rossomacha, E., Sun, J., Chevrier, A., Shive, M. S., & Buschmann, M. D. (2005) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.d.02536 · Cited by 305
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Aigner, T. G. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.08.009 · Cited by 287
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Hao, T., Wen, N., Cao, J., et al. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.08.007 · Cited by 154
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Cheng, Y., Yang, S., Su, W., Chen, Y., Yang, K., Cheng, W. T., Wu, S., & Lin, F. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0229 · Cited by 131
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Rockwood, D. N., Gil, E. S., Park, S.-H., Kluge, J. A., Grayson, W. L., Bhumiratana, S., Rajkhowa, R., Wang, X., Kim, S. J., Vunjak‐Novakovic, G., et al. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.07.020 · Cited by 119
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Zhao, Q. S., Ji, Q. X., Xing, K., et al. (2008) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2008.11.020 · Cited by 114
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Tang, Y., Wang, X., Li, Y., Lei, M., Du, Y., Kennedy, J. F., & Knill, C. J. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.06.003 · Cited by 114
Synthesis and characterization of a new thermosensitive chitosan–PEG diblock copolymer
Ganji, F., & Abdekhodaie, M. J. (2008) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2008.03.017 · Cited by 103
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Crompton, K. E., Prankerd, R. J., Paganin, D. M., et al. (2005) · Biophysical Chemistry · doi:10.1016/j.bpc.2005.03.009 · Cited by 100
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Dang, Q. F., Yan, J. Q., Li, J. J., et al. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.07.038 · Cited by 99
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Ragetly, G. R., Griffon, D. J., Lee, H., Fredericks, L. P., Gordon‐Evans, W. J., & Chung, Y. S. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.10.040 · Cited by 97
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Baek, H. S., Park, Y. H., Ki, C. S., Park, J., & Rah, D. K. (2008) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2008.06.154 · Cited by 92
Synthesis, characterization and immunogenicity of silk fibroin-l-asparaginase bioconjugates
Zhang, Y., Zhou, W.-L., Shen, W., Chen, Y., Zha, X., Shirai, K., & Kiguchi, K. (2005) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2005.06.027 · Cited by 90
Material properties and osteogenic differentiation of marrow stromal cells on fiber-reinforced laminated hydrogel nanocomposites
Xu, W., Ma, J., & Jabbari, E. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.12.003 · Cited by 84
Genipin‐Modified Silk‐Fibroin Nanometric Nets
Silva, S. S., Maniglio, D., Motta, A., et al. (2008) · Macromolecular Bioscience · doi:10.1002/mabi.200700300 · Cited by 75
Post-spinning modification of electrospun nanofiber nanocomposite from Bombyx mori silk and carbon nanotubes
Gandhi, M., Yang, H., Shor, L., & Ko, F. (2009) · Polymer · doi:10.1016/j.polymer.2009.02.022 · Cited by 73
Preparation, fabrication and biocompatibility of novel injectable temperature-sensitive chitosan/glycerophosphate/collagen hydrogels
Song, K., Qiao, M., Liu, T., et al. (2010) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-010-4131-4 · Cited by 72
The osteogenic differentiation of dog bone marrow mesenchymal stem cells in a thermo-sensitive injectable chitosan/collagen/β-glycerophosphate hydrogel: in vitro and in vivo
Sun, B., Ma, W., Su, F., et al. (2011) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-011-4386-4 · Cited by 66
Silk fibroin/chitosan–hyaluronic acid versus silk fibroin scaffolds for tissue engineering: promoting cell proliferations in vitro
Chung, T., & Chang, Y. L. (2010) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-009-3876-0 · Cited by 51
The osteogenic differentiation of dog bone marrow mesenchymal stem cells in a thermo-sensitive injectable chitosan/collagen/ b-glycerophosphate hydrogel: in vitro and in vivo
MaFang, B. S., & Wang, S. (2011) · Cited by 51
Perichondrium directed cartilage formation in silk fibroin and chitosan blend scaffolds for tracheal transplantation
Zang, M., Zhang, Q., Davis, G., et al. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.05.012 · Cited by 50
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Steck, E., Bertram, H., Walther, A., et al. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0817 · Cited by 33
Chondrogenesis on BMP‐6 loaded chitosan scaffolds in stationary and dynamic cultures
Tığlı, R. S., & Gümüşderelı́oğlu, M. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22426 · Cited by 25
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Seo, Y., & Park, J. (2010) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-009-0159-z · Cited by 12

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Authors: Mirahmadi, F., Tafazzoli-Shadpour, M., Shokrgozar, M. A., & Bonakdar, S.
Affiliations: Pasteur Institute of Iran (IR)
Corresponding author: Shokrgozar, Mohammad Ali
ORCID: Mirahmadi, Fereshteh
Shokrgozar, Mohammad Ali
Bonakdar, Shahin
Venue: Materials Science and Engineering C
Publisher: Elsevier BV
Published: 2013-12
Volume: 33
Issue: 8
Pages: 4786-4794
ISSN: 0928-4931 (ISSN-L)
DOI: 10.1016/j.msec.2013.07.043
OpenAlex: W2007845729
Cited by: 232
References: 57
Citations by year: 2026: 5 · 2025: 13 · 2024: 12 · 2023: 11 · 2022: 23 · 2021: 21 · 2020: 24 · 2019: 27 · 2018: 19 · 2017: 24 · 2016: 25 · 2015: 19 · 2014: 7 · 2013: 1
FWCI: 6.62
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Materials Science and Engineering C (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords: thermosensitive hydrogel, articular cartilage regeneration, cartilage tissue engineering, mechanical reinforcement, chondrocyte seeding, glycosaminoglycans, type II collagen, chondrogenic differentiation
MeSH terms: Animals, Biocompatible Materials, Cartilage, Articular, Cell Survival, Cells, Cultured, Fibroins, Glycerophosphates, Glycosaminoglycans, Rabbits, Regeneration, Rheology, Water, Chondrocytes, Hydrogels, Hydrogel, Polyethylene Glycol Dimethacrylate, Tissue Engineering, Collagen Type II, Chitosan, Cell Proliferation, Tissue Scaffolds, Nanofibers

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Enhanced mechanical properties of thermosensitive chitosan hydrogel by silk fibers for cartilage tissue engineering

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