The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Synthesis and characterization of biodegradable polyurethane films based on HDI with hydrolyzable crosslinked bonds and a homogeneous structure for biomedical applications
Abstract
Synthetic biodegradable polymers are considered strategic in the biomaterials field and are used in various applications. Among the polymers used as biomaterials, polyurethanes (PUs) feature prominently due to their versatility and the ability to obtain products with a wide range of physical and mechanical properties. In this work, new biodegradable polyurethane films were developed based on hexamethylene diisocyanate (HDI) and glycerol as the hard segment (HS), and poly(caprolactone) triol (PCL triol) and low-molecular-weight poly(ethylene glycol) PEG as the soft segment (SS) without the use of a catalyst. The films obtained were characterized by structural, mechanical and biological testing. A highly connected network with a homogeneous PU structure was obtained due to crosslinked bonds. The films showed amorphous structures, high water uptake, hydrogel behavior, and susceptibility to hydrolytic degradation. Mechanical tests indicated that the films reached a high deformation at break of up to 425.4%, an elastic modulus of 1.6 MPa and a tensile strength of 3.6 MPa. The materials presented a moderate toxic effect on MTT assay and can be considered potential materials for biomedical applications.
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“In addition, the biocompatibility of the main precursors in our SMPs has been previously demonstrated (38, 39).”
From Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording (2019) · cites this paper as [38]
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Research works printed but not linked: 1
- Yuan, 2013, vol. 51
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Zhang, Y., Zheng, N., Cao, Y., Wang, F., Wang, P., Ma, Y., Lu, B., Hou, G., Fang, Z., Liang, Z., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw1066 · Cited by 314
Metadata
- Authors
- Barrioni, B. R., de Carvalho, S. M., Oréfice, R. L., de Oliveira, A. A. R., & Pereira, M. D. M.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Corresponding author
- Barrioni, Breno Rocha
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 52
- Pages
- 22-30
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2035638395
- Cited by
- 189
- References
- 59
- Citations by year
- 2026: 7 · 2025: 19 · 2024: 18 · 2023: 9 · 2022: 16 · 2021: 19 · 2020: 20 · 2019: 17 · 2018: 23 · 2017: 23 · 2016: 15 · 2015: 3
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Funders
- CNPq
- CAPES
- FAPEMIG/Brazil
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer composites and self-healing
- Keywords
- hexamethylene diisocyanate, hydrolytic degradation, water absorption, mechanical properties, cytotoxicity, biomedical materials
- MeSH terms
- Materials Testing, Polyurethanes, Water, Hydrogel, Polyethylene Glycol Dimethacrylate
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