Effects of polydeoxyribonucleotides (PDRN) on wound healing: Electric cell-substrate impedance sensing (ECIS)
Abstract
Polydeoxyribonucleotides (PDRN) have been explored as an effective treatment for tissue repair in peripheral artery occlusive disease, diabetic foot ulcers, and eye lotion. We report on the effect of polydeoxyribonucleotides (PDRN) on wound healing by using the electric cell-substrate impedance sensing (ECIS) system and viability testing. Human osteoblasts (U2OS) and primary human dermal fibroblasts (HDF) were used to study the effect of PDRN on migration and proliferation. ECIS allowed the creation of a wound by applying high current, and then monitoring the healing process by measuring impedance in real time. The traditional culture-insert gap-closure migration assay was performed and compared with the ECIS wound assay. PDRN-treated U2OS and HDF cells affected cell motilities to wounding site. Viability test results show that HDF and U2OS proliferation depended on PDRN concentration. Based on the results, a PDRN compound can be useful in wound healing associated with bone and skin.
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PDRN accelerates wound healing.
“For instance, PDRN has been shown to stimulate the proliferation of skin fibroblasts [52] and osteoblasts [53], accelerate wound healing [25,54], promote angiogenesis [55], and exert notable anti-inflammatory effects [56].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [54]
Cites
Delayed Wound Healing in CXCR2 Knockout Mice
Devalaraja, R. M., Nanney, L. B., Qian, Q., Du, J., Yu, Y., Devalaraja, M. N., & Richmond, A. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00034.x · Cited by 429 · see citing works
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Colangelo, M. T., Galli, C., & Guizzardi, S. (2020) · Regenerative Medicine · doi:10.2217/rme-2019-0118 · Cited by 59 · see citing works
Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
- Authors
- Koo, Y., & Yun, Y.
- Affiliations
- North Carolina Agricultural and Technical State University (US)
- Corresponding author
- Yun, Yeoheung
- ORCID
- Yun, Yeoheung
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 69
- Pages
- 554-560
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2473873905
- Cited by
- 37
- References
- 1
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 2
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Materials Science and Engineering C (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NSF Engineering Research Center (ERC) for Revolutionizing Metallic Biomaterials (0812348)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- polydeoxyribonucleotide, wound healing, electric cell-substrate impedance sensing, cell migration, cell proliferation, osteoblasts, dermal fibroblasts, cell viability, bone regeneration, skin wound healing
- MeSH terms
- Adult, Animals, Cell Movement, Fibroblasts, Humans, Microelectrodes, Polydeoxyribonucleotides, Wound Healing, Dermis, Cell Line, Tumor, Cell Shape, Dielectric Spectroscopy
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