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Mesenchymal Stem Cell‐Inspired Microneedle Platform for NIR‐responsive Immunomodulation and Accelerated Chronic Wound Healing

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Current practices and perceived effectiveness of polynucleotides for treatment of facial erythema by cosmetic physicians

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Review: functionalization of biopolymer-based electrospun nanofibers for wound healing

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A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes Wound Healing in a Primary Gingival Fibroblast Model

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Versatile and Marvelous Potentials of Polydeoxyribonucleotide for Tissue Engineering and Regeneration

Oh, N., Hwang, J., Kang, M. S., Yoo, C.-Y., Kwak, M., & Han, D.-W. (2025) · Biomaterials Research · doi:10.34133/bmr.0183 · Cited by 25 · see citing works

Development and characterization of polydeoxyribonucleotide (PDRN) loaded chitosan polyplex: In vitro and in vivo evaluation of wound healing activity

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Recent advances on polydeoxyribonucleotide extraction and its novel application in cosmeceuticals

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Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives

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Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors

Valls, M. D., Soldado, M., Arasa, J., Pérez‐Aso, M., Williams, A. J., Cronstein, B. N., Noguera, M. A., Terencio, M. C., & Montesinos, M. C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.654104 · Cited by 18 · see citing works

Polydeoxyribonucleotides Pre-Clinical Findings in Bone Healing: A Scoping Review

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Proteomics Analysis of the Protective Effect of Polydeoxyribonucleotide Extracted from Sea Cucumber (Apostichopus japonicus) Sperm in a Hydrogen Peroxide-Induced RAW264.7 Cell Injury Model

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Polydeoxyribonucleotides as Emerging Therapeutics for Skin Diseases: Clinical Applications, Pharmacological Effects, Molecular Mechanisms, and Potential Modes of Action

Park, S., Baek, S., Shin, H.-J., Kim, J.-S., Gwon, H.-I., 배승희, & An, S. (2025) · Applied Sciences · doi:10.3390/app151910437 · Cited by 12 · see citing works

Efficacy of Polydeoxyribonucleotide in Promoting the Healing of Diabetic Wounds in a Murine Model of Streptozotocin-Induced Diabetes: A Pilot Experiment

Yun, J. Y., Park, S., Park, H. Y., & Lee, K. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031932 · Cited by 11 · see citing works

Effects of Chlorella protothecoides-derived polydeoxyribonucleotides on skin regeneration and wound healing

Park, J. M., Nam, G. B., Lee, E.-S., Kim, H.-M., Kim, H., Myoung, K., Lee, J. E., Baek, H. S., Ko, J., & Lee, C. S. (2025) · Archives of Dermatological Research · doi:10.1007/s00403-025-03885-w · Cited by 7 · see citing works

Polydeoxyribonucleotide as a Regenerative Agent in Dermatology and Wound Healing: Mechanisms, Clinical Applications, and Safety

Park, G.-Y., & Jang, B. (2025) · Gyemyeong uidae haksulji · doi:10.46308/kmj.2025.00115 · Cited by 12 · see citing works

Glutathione in Skin Aging and Tissue Regeneration: A Systematic Review of Molecular Mechanisms, Redox Modulation, and Biomedical Implications

Stanescu, C. M., Chiscop, I., Boev, M., Stanescu, G. D., & Matei, M. N. (2026) · Molecules · doi:10.3390/molecules31060981 · Cited by 9 · see citing works

Comparative Analysis of Melatonin and Polydeoxyribonucleotide: Possible Benefits of Co-Treatment Effects and Potential Synergistic Applicability

Jang, S. K., Choi, J., Lim, H. W., Kim, H.-G., & Yoo, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125703 · Cited by 8 · see citing works

Injectable in situ–forming silk fibroin–based hydrogel dressing with MXene/polydeoxyribonucleotide for wound protection and regeneration

Jang, J., Chung, H.-R., Lee, S.-M., Lee, E.-J., & Han, C. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145773 · Cited by 7 · see citing works

Results of Shoulder Adhesive Capsulitis Treatment With the Use of Platelet Rich Plasma and Nucleotide Drugs: A Comparative Study

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A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes the Growth of 3D Spheroid Cultures of Gingival Fibroblasts

Colangelo, M. T., Vicedomini, M. L., Belletti, S., Govoni, P., Guizzardi, S., & Galli, C. (2023) · Applied Sciences · doi:10.3390/app13020743 · Cited by 7 · see citing works

Polydeoxyribonucleotide (PDRN) in Dentistry: Narrative Review for Mechanisms and Emerging Clinical Applications

Ku, J. H., Yun, P., & Jeong, Y. K. (2026) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-025-00776-z · Cited by 8 · see citing works

Effect of Polydeoxyribonucleotide on Human Periodontal Ligament Cells as a Storage Medium for Avulsed Tooth

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Non-surgical treatment of diabetic foot ulcers on the dorsum of the foot with polydeoxyribonucleotide injection: Two case reports

Ha, Y., Kim, J.-H., Kim, J., & Kwon, H. (2024) · World Journal of Clinical Cases · doi:10.12998/wjcc.v12.i20.4446 · Cited by 6 · see citing works

Effects of Polydeoxyribonucleotide ( PDRN ) on Endosinus Bone Regeneration Following Sinus Floor Elevation: An Experimental In Vivo Pilot Study

Lim, H., Hong, J., Shin, S., Chung, J., Thoma, D. S., Jung, R. E., & Lim, H. (2024) · Clinical Oral Implants Research · doi:10.1111/clr.14378 · Cited by 5 · see citing works

The impact of polydeoxyribonucleotide on wound healing: a systematic review

Naik, V., Chodankar, S., Pereira, M., & Loliyekar, A. (2025) · International Surgery Journal · doi:10.18203/2349-2902.isj20250816 · Cited by 5 · see citing works

Effects of polydeoxyribonucleotide derived from Gynostemma pentaphyllum callus on skin barrier function

Kim, E. H., Choi, S., Jang, J., Shin, H., Ahn, K., Kim, S.-J., Seo, H. H., Lee, J. H., & Moh, S. H. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152180 · Cited by 4 · see citing works

Safety Validation of Plant-Derived Materials for Skin Application

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Nucleic Acid-Based Therapeutics for Periodontal Tissue Regeneration: A Comprehensive Review

Kim, J.-Y., Hong, M., Kim, S., & Garagiola, U. M. (2025) · Applied Sciences · doi:10.3390/app152111655 · Cited by 4 · see citing works

A Multicomponent Salmon PDRN/Sodium Alginate/Gelatin Hydrogel Promotes Infected Wound Repair in Rat

Zhao, Y., Wang, Y., Sheng, W., Xia, Q., Li, X., Stoika, R. S., Cai, L., & Wang, L. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c01383 · Cited by 3 · see citing works

In Vitro Evidence for Oral Soft Tissue Regenerative Effects of a Polynucleotide–Hyaluronan Formulation

Mladenova, I., Song, X., Nica, C., Sculean, A., & Asparuhova, M. B. (2025) · Clinical and Experimental Dental Research · doi:10.1002/cre2.70253 · Cited by 3 · see citing works

Nanoformulated PDRN Improves Anti‐Inflammatory and Wound Healing Activities

Kang, J., Jeon, M. J., Kim, S., Hwang, W. K., & Lee, M. (2026) · Macromolecular Bioscience · doi:10.1002/mabi.202500373 · Cited by 3 · see citing works

Paeonia lactiflora Callus-Derived Polynucleotides Enhance Collagen Accumulation in Human Dermal Fibroblasts

Hwang, S., Park, S., Lee, J. W., Park, M., Nguyệt, L. Á., Hwang, Y., Ahn, K., Shin, H.-Y., & Son, K. H. (2026) · Journal of Functional Biomaterials · doi:10.3390/jfb17010056 · Cited by 3 · see citing works

Elucidating Interactome Dynamics of the A2A Adenosine Receptor in the Presence of Polydeoxyribonucleotide

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Intra-articular Injection Therapy and Biologic Treatment

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Intramuscular Polydeoxyribonucleotides in Fibrotic and Atrophic Localized Scleroderma: An Explorative Prospective Cohort Study

Romagnuolo, M., Moltrasio, C., Marzano, A. V., Nazzaro, G., Muratori, S., & Recalcati, S. (2023) · Biomedicines · doi:10.3390/biomedicines11041190 · Cited by 3 · see citing works

The Prosthetic Rehabilitation of Maxillary Aesthetic Area Guided by a Multidisciplinary Approach: A Case Report with Histomorphometric Evaluation

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Polynucleotides and Polydeoxyribonucleotides for Skin Rejuvenation, Postoperative Scar Prevention, and Wound Healing: A Systematic Review of Randomized Clinical Trials

Alhussain, A. M., Turki M. Albusayys, S., Alfhadi, M. A., Bu Mozah, S. A., AlShammari, S. S. S., Alanazi, H. A. M., Adil Alqazanli, S., Nouruldeen Alabdullah, A., M. ALrashidi, N., Almazrou, A. A., et al. (2026) · Cureus · doi:10.7759/cureus.112403 · Cited by 1 · see citing works

Biomimetic aligned bacterial cellulose dressing containing polydeoxyribonucleotide for promoting wound healing

Zhu, X., Liu, F., Jin, T., Chen, H., Chung, S., Chen, C., & Lee, I.-S. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.08.017 · Cited by 1 · see citing works

Efficacy of polynucleotide, fractional CO2 laser, and their combination in treating striae distensae: a randomized intraindividual clinical trial

Thanasarnaksorn, W., Sintopachakul, M., Suwanachinda, A., & Sirithanabadeekul, P. (2025) · Archives of Dermatological Research · doi:10.1007/s00403-025-04348-y · Cited by 1 · see citing works

Polydeoxyribonucleotide (PDRN) in Post-procedure Recovery in Aesthetic Medicine: A Narrative Review

Rodríguez, J. C. F., Avelar, L. E. T., Yi, K., Arellano, R. M., Zamora, B. M. P., & Martínez, L. V. (2026) · Cureus · doi:10.7759/cureus.108886 · Cited by 1 · see citing works

Regenerative Aesthetics: Present Advances and Emerging Strategies for Optimized Tissue Health

Cattelan, L., Dayan, S. H., Cohen, S., Muniz, M., & Fabi, S. G. (2026) · Dermatologic Surgery · doi:10.1097/dss.0000000000004985 · Cited by 1 · see citing works

Polynukleotide und ihre Anwendung in der ästhetischen Medizin

Last, J. (2023) · ästhetische dermatologie & kosmetologie · doi:10.1007/s12634-023-2288-3

Vabip (Vaginal Biorevitalization With Polydeoxyribonucleotides) Randomized Controlled Trial for the Genitourinary Syndrome of MenopausePreprint

Ocampo‐Godínez, J. M., Loranca-Moreno, P., Cruz-Alcázar, C., Morales, M. D., González-Cruz, S., Rios-Espinosa, A., González-Quiroz, J. L., Vázquez-Vázquez, F. C., Grimaldo, L., Álvarez-Pérez, M. A., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4272255/v1

Elucidating Interactome Dynamics of the A2A Adenosine ReceptorPreprint

Lee, W., Son, A., Kim, W., Park, J., Cho, J. Y., Kim, J.-W., Kim, Y., Kong, H. J., & Kim, H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.08.601789

Effect of Polydeoxyribonucleotide-Releasing Contact Lenses on Corneal Wound Healing

Ryu, Y., Son, H.-J., Hwang, J. S., Oh, S., Lee, J., Kim, G. B., & Shin, Y. J. (2025) · Eye & Contact Lens Science & Clinical Practice · doi:10.1097/icl.0000000000001235

Microagulhamento associado ao Polidesoxirribonucleotideo nas difusões estéticas: revisão narrativa

Brito, N. V. D. S., de Araújo, M. O. C., & Silva, M. S. (2026) · Revista Multidisciplinar do Nordeste Mineiro · doi:10.66104/ryvhdg20

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Cruel, P. T. E., dos dos Santos, C. P. C., Buchaim, D. V., González, S. Y. C., Rosa, G. M., RIBEIRO, C. A., Reis, C. H. B., & Buchaim, R. L. (2026) · Cosmetics · doi:10.3390/cosmetics13030139

Mechanistic Review of Topical Therapies Targeting Dermal Fibroblasts in Skin Aging and Rejuvenation

Akaberi, S. M., Esfandiyari, M., & Ashtiani, H. R. A. (2026) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70987

Time-dependent effects of polydeoxyribonucleotide on vascularity, pigmentation, texture, and height of facial surgical scars: A longitudinal analysis

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Plant-Derived Polynucleotides/Polydeoxyribonucleotides in Skin Biomaterials: Delivery Platforms and Bioactivity Attribution

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Multifunctional therapeutic platform based on polydeoxyribonucleotide-loaded calcium carbonate particles for osteoarthritis management

Jung, S. Y., Hak-Jun, K., Kim, S. E., & Park, K. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.116099

Early scar-directed interventions for thyroidectomy scars: a systematic review and network meta-analysis

Yu, K., Hao, Z., & Sun, J. (2026) · Frontiers in Surgery · doi:10.3389/fsurg.2026.1914326

Preparation and characterization of polydeoxyribonucleotide-poly(L-lysine) nanospheres with high penetration and hydrating properties for skin applications

Hu, W., Wu, H., Zhao, C., Liu, Y., Zhao, C., Meng, H., & Pei, X. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.116211

CLINICAL AND MORPHOLOGICAL RATIONALE FOR THE USE OF POLYNUCLEOTIDES IN THE TREATMENT OF POSTOPERATIVE SCARS: BLEPHAROPLASTY AS A CLINICAL MODEL (LITERATURE REVIEW)

Sichnenko, D., & Romaniuk, A. M. (2026) · Eastern Ukrainian Medical Journal · doi:10.21272/eumj.2026;14(3);779-794

Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing

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Polydeoxyribonucleotide as a Regenerative Agent in Dermatology and Wound Healing: Mechanisms, Clinical Applications, and Safety

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The impact of polydeoxyribonucleotide on wound healing: a systematic review

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