Bisphosphonate-incorporated coatings for orthopedic implants functionalization
Open accessAbstract
Bisphosphonates (BPs), the stable analogs of pyrophosphate, are well-known inhibitors of osteoclastogenesis to prevent osteoporotic bone loss and improve implant osseointegration in patients suffering from osteoporosis. Compared to systemic administration, BPs-incorporated coatings enable the direct delivery of BPs to the local area, which will precisely enhance osseointegration and bone repair without the systemic side effects. However, an elaborate and comprehensive review of BP coatings of implants is lacking. Herein, the cellular level (e.g., osteoclasts, osteocytes, osteoblasts, osteoclast precursors, and bone mesenchymal stem cells) and molecular biological regulatory mechanism of BPs in regulating bone homeostasis are overviewed systematically. Moreover, the currently available methods (e.g., chemical reaction, porous carriers, and organic material films) of BP coatings construction are outlined and summarized in detail. As one of the key directions, the latest advances of BP-coated implants to enhance bone repair and osseointegration in basic experiments and clinical trials are presented and critically evaluated. Finally, the challenges and prospects of BP coatings are also purposed, and it will open a new chapter in clinical translation for BP-coated implants.
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In vivo studies using animal bone defect models demonstrate that PDA-functionalized scaffolds exhibit pronounced bone regeneration capability.
“In vivo studies using animal bone defect models have demonstrated that such PDA-functionalized scaffolds exhibit pronounced bone regeneration capability, highlighting their potential as alternative therapeutic strategies in maxillofacial reconstructive surgery.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [35]
The section on BP-coated organic materials (Fig. 12; page unavailable) reports bone repair after gelatin/alendronate-coated scaffolds were implanted into rat calvarial defects. It does not establish the claimed result for PDA-functionalized scaffolds; the reported coating is different. (LLM, conf=0.82)
Experimental — accuracy not yet measuredWithin porous scaffold architectures, PDA deposition improves surface hydrophilicity and cytocompatibility and functions as a mineralization template facilitating apatite nucleation and deposition, and incorporation of PDA nanoparticles into hydrogel matrices markedly enhances their mechanical properties, tissue adhesive strength, and osteogenic activity.
“Within porous scaffold architectures, PDA deposition not only improves surface hydrophilicity and cytocompatibility but also functions as an effective mineralization template, facilitating apatite nucleation and deposition and thereby establishing a biomimetic microenvironment conducive to bone tissue regeneration.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [35]
Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredIn vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.
“In vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [35]
The Physical adsorption section mentions dopamine (DOPA) only as a pretreatment for grafting heparin onto implants. The BP-coated with inorganic materials section reports cell adhesion, osteogenic differentiation, and osseointegration for bisphosphonate-containing coatings, not PDA. Searches for polydopamine, hydroxyapatite nucleation, dentin sealing, and bonding tests found no passage supporting the claimed effects of PDA; page numbers were not available in our copy. (LLM, conf=0.76)
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Sol–gel derived titania coating with immobilized bisphosphonate enhances screw fixation in rat tibia
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Cited by
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Nano-Based Approaches in Surface Modifications of Dental Implants: A Literature Review
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Self-citationFunctions of Epimedin C in a zebrafish model of glucocorticoid‐induced osteoporosis
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Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration
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Scaffold-Mediated Microenvironmental Modulation Targeting Osteoclasts for ONFH Niche Reprogramming
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Self-citationFunctionalized zeolite regulates bone metabolic microenvironment
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Self-citationCalcium Medronate-Based Metal–Organic Frameworks as Multifunctional Biomaterials
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Electrochemical C(sp 2 )‐H Diphosphorylation With a Redox Mediator: Access to Gem ‐Bisphosphonates
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“35 In vivo studies using animal bone defect models have demonstrated that such PDA-functio-nalized scaffolds exhibit pronounced bone regeneration capability, highlighting their potential as alternative therapeutic strategies in maxillofacial reconstructive surgery.”
Odanacatib Coating Supports Osseointegration of Implants: A Preclinical Study
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Pharmacological Strategies to Enhance Bone Graft Integration: Emerging Agents and Molecular Pathways
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- Authors
- Zhang, J., Bai, H., Bai, M., Wang, X., Li, Z., Xue, H., Wang, J., Cui, Y., Wang, H., Wang, Y., Zhou, R., Zhu, X., Xu, M., Zhao, X., & Liu, H.
- Affiliations
- Jilin University (CN)
- Corresponding author
- Zhao, Xin
- Liu, He
- ORCID
- Venue
- Materials Today Bio
- Publisher
- Elsevier BV
- Published
- 2023-10
- Volume
- 22
- Pages
- 100737
- ISSN
- 2590-0064 (ISSN-L)
- PMC
- PMC10413202
- OpenAlex
- W4385076688
- Cited by
- 22
- References
- 234
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 8
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials Today Bio (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Science Foundation of Jilin Province (YDZJ202201ZYTS086)
- Jilin Province Development and Reform Commission (2022C044-2)
- National Natural Science Foundation of China (82001971, 82202698, U21A2099)
- Jilin University (2022B27, 2022JBGS06, 419161900014)
- Wu Jieping Medical Foundation (320.6750.18522)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- bisphosphonates, orthopedic implants, implant coatings, osseointegration, bone regeneration, osteoclastogenesis inhibition, bone homeostasis, osteoporosis, local drug delivery, porous carrier, organic films, bone mesenchymal stem cells, osteoblasts, osteocytes, clinical translation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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