Cited by 23Bone Tissue Engineering MaterialsOrthopaedic implants and arthroplastyBone health and treatments

Bisphosphonate-incorporated coatings for orthopedic implants functionalization

Open access
Zhang, Jiaxin, Bai, Haotian, Bai, Miao, Wang, Xiaonan, Li, ZuHao, Xue, Haowen, Wang, Jincheng, Cui, Yutao +7 more·2023·Materials Today Bio

Abstract

Bisphosphonates (BPs), the stable analogs of pyrophosphate, are well-known inhibitors of osteoclastogenesis to prevent osteoporotic bone loss and improve implant osseointegration in patients suffering from osteoporosis. Compared to systemic administration, BPs-incorporated coatings enable the direct delivery of BPs to the local area, which will precisely enhance osseointegration and bone repair without the systemic side effects. However, an elaborate and comprehensive review of BP coatings of implants is lacking. Herein, the cellular level (e.g., osteoclasts, osteocytes, osteoblasts, osteoclast precursors, and bone mesenchymal stem cells) and molecular biological regulatory mechanism of BPs in regulating bone homeostasis are overviewed systematically. Moreover, the currently available methods (e.g., chemical reaction, porous carriers, and organic material films) of BP coatings construction are outlined and summarized in detail. As one of the key directions, the latest advances of BP-coated implants to enhance bone repair and osseointegration in basic experiments and clinical trials are presented and critically evaluated. Finally, the challenges and prospects of BP coatings are also purposed, and it will open a new chapter in clinical translation for BP-coated implants.

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Crossref · 10.1016/j.mtbio.2023.100737

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  • In vivo studies using animal bone defect models demonstrate that PDA-functionalized scaffolds exhibit pronounced bone regeneration capability.

    “In vivo studies using animal bone defect models have demonstrated that such PDA-functionalized scaffolds exhibit pronounced bone regeneration capability, highlighting their potential as alternative therapeutic strategies in maxillofacial reconstructive surgery.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [35]

    The section on BP-coated organic materials (Fig. 12; page unavailable) reports bone repair after gelatin/alendronate-coated scaffolds were implanted into rat calvarial defects. It does not establish the claimed result for PDA-functionalized scaffolds; the reported coating is different. (LLM, conf=0.82)

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  • Within porous scaffold architectures, PDA deposition improves surface hydrophilicity and cytocompatibility and functions as a mineralization template facilitating apatite nucleation and deposition, and incorporation of PDA nanoparticles into hydrogel matrices markedly enhances their mechanical properties, tissue adhesive strength, and osteogenic activity.

    “Within porous scaffold architectures, PDA deposition not only improves surface hydrophilicity and cytocompatibility but also functions as an effective mineralization template, facilitating apatite nucleation and deposition and thereby establishing a biomimetic microenvironment conducive to bone tissue regeneration.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [35]

    Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.

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  • In vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.

    “In vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [35]

    The Physical adsorption section mentions dopamine (DOPA) only as a pretreatment for grafting heparin onto implants. The BP-coated with inorganic materials section reports cell adhesion, osteogenic differentiation, and osseointegration for bisphosphonate-containing coatings, not PDA. Searches for polydopamine, hydroxyapatite nucleation, dentin sealing, and bonding tests found no passage supporting the claimed effects of PDA; page numbers were not available in our copy. (LLM, conf=0.76)

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4 of the 234 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. [157]Giger E.V. Castahner B. Leroux J.C. Biomedical applications of bisphosphonates J. Contr. Release 167 2013 175 188 10.1016/j.jconrel.2013.01.032 23395668 · DOI
  2. [185]Greiner S. Kadow-Romacker A. Wildemann B. Schwabe P. Schmidmaier G. Bisphosphonates incorporated in a poly(D,L-lactide) implant coating inhibit osteoclast like cells in vitro J. Biomed. Mater. Res. 83 4 2007 1184 1191 10.1002/jbm.a.31444 17595027 · DOI
  3. [221]Ma T. Ge X.Y. Hao K.Y. Zhang B.R. Jiang X. Lin Y. Zhang Y. Simple 3,4-Dihydroxy-L-Phenylalanine surface modification enhances titanium implant osseointegration in ovariectomized rats Sci. Rep. 7 1 2017 17849 10.1038/s41598-017-18173-5 PMC5736607 29259343 · DOI

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Authors
Zhang, J., Bai, H., Bai, M., Wang, X., Li, Z., Xue, H., Wang, J., Cui, Y., Wang, H., Wang, Y., Zhou, R., Zhu, X., Xu, M., Zhao, X., & Liu, H.
Affiliations
Jilin University (CN)
Corresponding author
  • Zhao, Xin
  • Liu, He
Venue
Materials Today Bio
Publisher
Elsevier BV
Published
2023-10
Volume
22
Pages
100737
ISSN
2590-0064 (ISSN-L)
OpenAlex
W4385076688
Cited by
22
References
234
Citations by year
2026: 3 · 2025: 11 · 2024: 8
FWCI
0.49
Type
journal article
Language
en
Open access
Locations
  • Materials Today Bio (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Natural Science Foundation of Jilin Province (YDZJ202201ZYTS086)
  • Jilin Province Development and Reform Commission (2022C044-2)
  • National Natural Science Foundation of China (82001971, 82202698, U21A2099)
  • Jilin University (2022B27, 2022JBGS06, 419161900014)
  • Wu Jieping Medical Foundation (320.6750.18522)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
  • Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords
bisphosphonates, orthopedic implants, implant coatings, osseointegration, bone regeneration, osteoclastogenesis inhibition, bone homeostasis, osteoporosis, local drug delivery, porous carrier, organic films, bone mesenchymal stem cells, osteoblasts, osteocytes, clinical translation

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