RNF213 deficiency in human iPSC-derived vascular organoids captures key feature of moyamoya disease vasculopathy

Moyamoya disease: current concepts and future perspectives

Kuroda, S., & Houkin, K. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70240-0 · Cited by 1,201 · see citing works

Human blood vessel organoids as a model of diabetic vasculopathy

Wimmer, R. A., Leopoldi, A., Aichinger, M., Wick, N., Hantusch, B., Novatchkova, M., Taubenschmid, J., Hämmerle, M., Esk, C., Bagley, J. A., et al. (2019) · Nature · doi:10.1038/s41586-018-0858-8 · Cited by 803 · see citing works

Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development

Liu, W., Morito, D., Takashima, S., Mineharu, Y., Kobayashi, H., Hitomi, T., Hashikata, H., Matsuura, N., Yamazaki, S., Toyoda, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022542 · Cited by 720 · see citing works

Feeder-independent culture of human embryonic stem cells

Ludwig, T. E., Bergendahl, V., Levenstein, M. E., Yu, J., Probasco, M. D., & Thomson, J. A. (2006) · Nature Methods · doi:10.1038/nmeth902 · Cited by 681 · see citing works

Moyamoya Disease: Epidemiology, Clinical Features, and Diagnosis

Kim, J. S. (2016) · Journal of Stroke · doi:10.5853/jos.2015.01627 · Cited by 501 · see citing works

The CCL5/CCR5 Axis in Cancer Progression

Aldinucci, D., Borghese, C., & Casagrande, N. (2020) · Cancers · doi:10.3390/cancers12071765 · Cited by 413 · see citing works

Moyamoya disease: diagnosis and interventions

Ihara, M., Yamamoto, Y., Hattori, Y., et al. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00165-x · Cited by 396 · see citing works

Generation of vascularized brain organoids to study neurovascular interactions

Sun, X.-Y., Ju, X.-C., Li, Y., Zeng, P.-M., Wu, J., Zhou, Y., Shen, L., Dong, J., Chen, Y., & Luo, Z. (2022) · eLife · doi:10.7554/elife.76707 · Cited by 390 · see citing works

DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery

Ye, C., Ho, D. J., Neri, M., Yang, C., Kulkarni, T., Randhawa, R., Henault, M., Mostacci, N., Farmer, P., Renner, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06500-x · Cited by 222 · see citing works

Organoids for Drug Discovery and Personalized Medicine

Takahashi, T. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021108 · Cited by 202 · see citing works

Inheritance pattern of familial moyamoya disease: autosomal dominant mode and genomic imprinting

Mineharu, Y. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.096040 · Cited by 179 · see citing works

Modeling Blood-Brain Barrier Formation and Cerebral Cavernous Malformations in human PSCs-derived organoids

Dao, L., You, Z., Lu, L., Xu, T.-Y., Sarkar, A. K., Zhu, H., Liu, M., Calandrelli, R., Yoshida, G., Lin, P., et al. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.04.019 · Cited by 164 · see citing works

Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering

Osaki, T., Sivathanu, V., & Kamm, R. D. (2018) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2018.03.011 · Cited by 141 · see citing works

The Genetic Basis of Moyamoya Disease

Mertens, R. G., Graupera, M., Gerhardt, H., Bersano, A., Tournier‐Lasserve, E., Mensah, M. A., Mundlos, S., & Vajkoczy, P. (2021) · Translational Stroke Research · doi:10.1007/s12975-021-00940-2 · Cited by 138 · see citing works

Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients

Hitomi, T., Habu, T., Kobayashi, H., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.07.004 · Cited by 128 · see citing works

Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213: A susceptibility gene for moyamoya disease

Sonobe, S., Fujimura, M., Niizuma, K., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.011 · Cited by 124 · see citing works

Moyamoya Disease and Spectrums of RNF213 Vasculopathy

Bang, O. Y., Chung, J., Kim, D. H., Won, H., Yeon, J. Y., Ki, C., Shin, H. J., Kim, J. S., Hong, S., Kim, D., et al. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00743-6 · Cited by 115 · see citing works

The ovalbumin serpins revisited: Perspective from the chicken genome of clade B serpin evolution in vertebrates

Benarafa, C., & Remold‐O’Donnell, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502934102 · Cited by 100 · see citing works

Vascular organoids: unveiling advantages, applications, challenges, and disease modelling strategies

Naderi‐Meshkin, H., Cornelius, V. A., Eleftheriadou, M., Potel, K. N., Setyaningsih, W. A. W., & Margariti, A. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03521-2 · Cited by 99 · see citing works

Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine

Yao, Q., Cheng, S., Pan, Q., Yu, J., Cao, G., Li, L., & Cao, H. (2024) · MedComm · doi:10.1002/mco2.735 · Cited by 97 · see citing works

Moyamoya: An Update and Review

Berry, J. A. D., Cortez, V., Toor, H., et al. (2020) · Cureus · doi:10.7759/cureus.10994 · Cited by 90 · see citing works

Blood–Brain Barrier and Neurodegenerative Diseases—Modeling with iPSC-Derived Brain Cells

Wu, Y., Sonninen, T.-M., Peltonen, S., Koıstınaho, J., & Lehtonen, Š. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147710 · Cited by 88 · see citing works

Vitamin D and regulation of vascular cell function

Jamali, N., Sorenson, C. M., & Sheibani, N. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00319.2017 · Cited by 88

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs

Bertero, A., Pawlowski, M., Ortmann, D., Snijders, K. E., Yiangou, L., de Brito, M. C., Brown, S. E., Bernard, W. G., Cooper, J. D., Giacomelli, E., et al. (2016) · Development · doi:10.1242/dev.138081 · Cited by 85 · see citing works

Moyamoya Disease in Pregnancy: A 20-Year Single-Center Experience and Literature Review

Inayama, Y., Kondoh, E., Chigusa, Y., et al. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.10.071 · Cited by 43 · see citing works

Chemokine Ligand 5 (CCL5) Derived from Endothelial Colony-Forming Cells (ECFCs) Mediates Recruitment of Smooth Muscle Progenitor Cells (SPCs) toward Critical Vascular Locations in Moyamoya Disease

Phi, J. H., Suzuki, N., Moon, Y. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169714 · Cited by 31 · see citing works

RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses

Zhang, L., Rashad, S., Zhou, Y., et al. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221110679 · Cited by 30 · see citing works

RNF213 Loss-of-Function Promotes Angiogenesis of Cerebral Microvascular Endothelial Cells in a Cellular State Dependent Manner

Roy, V., Brodeur, A., Touzel‐Deschênes, L., et al. (2022) · Cells · doi:10.3390/cells12010078 · Cited by 30 · see citing works

The Role of TRPM2 in Endothelial Function and Dysfunction

Zielińska, W., Zabrzyński, J., Gagat, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147635 · Cited by 28 · see citing works

Physiological and pathophysiological mechanisms of the molecular and cellular biology of angiogenesis and inflammation in moyamoya angiopathy and related vascular diseases

Dorschel, K. B., & Wanebo, J. E. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.661611 · Cited by 28 · see citing works

The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis

Simons, K. H., Aref, Z., Peters, H. A. B., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.02.015 · Cited by 25 · see citing works

Human cardiac organoids: A recent revolution in disease modeling and regenerative medicine

Roshanravan, N., Ghaffari, S., Bastani, S., Pahlavan, S., Asghari, S., Doustvandi, M. A., Razin, S. J., & Dastourı, M. (2023) · Journal of Cardiovascular and Thoracic Research · doi:10.34172/jcvtr.2023.31830 · Cited by 25 · see citing works

RNF213 in moyamoya disease: Genotype–phenotype association and the underlying mechanism

Fang, J., Yang, X., & Ni, J. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002985 · Cited by 22 · see citing works

Mutations of RNF213 are responsible for sporadic cerebral cavernous malformation and lead to a mulberry-like cluster in zebrafish

Lin, J., Liang, J., Wen, J., Luo, M., Li, J., Sun, X., Xu, X., Li, J., Wang, D., Wang, J., et al. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20914996 · Cited by 21 · see citing works

The association between the ring finger protein 213 (RNF213) polymorphisms and moyamoya disease susceptibility: a meta-analysis based on case–control studies

Sun, X., Wen, J., Li, J., et al. (2016) · Molecular Genetics and Genomics · doi:10.1007/s00438-016-1172-5 · Cited by 18 · see citing works

Human iPS Cell-derived Tissue Engineered Vascular Graft: Recent Advances and Future Directions

Shi, X., He, L., Zhang, S., & Luo, J. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10091-w · Cited by 18 · see citing works

Induced Pluripotent Stem Cells (iPSCs) in Vascular Research: from Two- to Three-Dimensional Organoids

Trillhaase, A., Märtens, M., Aherrahrou, Z., & Erdmann, J. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10149-3 · Cited by 18 · see citing works

Modelling Alzheimer's disease using human brain organoids: current progress and challenges

Yanakiev, M., Soper, O., Berg, D. A., & Kang, E. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.40 · Cited by 16 · see citing works

C1q contributes to post-stroke angiogenesis via LAIR1-HIF1 alpha -VEGF pathway

Qian, J. (2019) · Frontiers in bioscience · doi:10.2741/4767 · Cited by 14 · see citing works

A Prospectus of Tenomodulin

Alexandrov, V. P., & Naimov, S. (2016) · Folia Medica · doi:10.1515/folmed-2016-0003 · Cited by 11 · see citing works

Exploring RNF213 in Ischemic Stroke and Moyamoya Disease: From Cellular Models to Clinical Insights

Tan, B. Y., Kok, C. H. P., Ng, M. B. J., Loong, S. S. E., Jou, E., Yeo, L. L. L., Han, W., Anderson, C. D., Khor, C. C., & Lai, P. S. (2024) · Biomedicines · doi:10.3390/biomedicines13010017 · Cited by 11 · see citing works

Circ_0003221 Downregulation Restrains Cervical Cancer Cell Growth, Metastasis and Angiogenesis by Governing the miR-139-3p/S100A14 Pathway

Chi, X., Gu, X., Chen, S., et al. (2022) · Reproductive Sciences · doi:10.1007/s43032-021-00815-9 · Cited by 9 · see citing works

Knockdown the moyamoya disease susceptibility gene, RNF213, upregulates the expression of basic fibroblast growth factor and matrix metalloproteinase-9 in bone marrow derived mesenchymal stem cells

Li, Z., Liu, Y., Li, X., et al. (2024) · Neurosurgical Review · doi:10.1007/s10143-024-02448-3 · Cited by 8 · see citing works

FIZZ1 could enhance the angiogenic ability of rat aortic endothelial cells.

Li, X., Yang, Y., Fang, J., & Zhang, H. (2013) · Europe PMC (PubMed Central) · Cited by 8 · see citing works

Association of Genetic Variants with Postoperative Donor Artery Development in Moyamoya Disease: RNF213 and Other Moyamoya Angiopathy-Related Gene Analysis

Torazawa, S., Miyawaki, S., Imai, H., et al. (2024) · Translational Stroke Research · doi:10.1007/s12975-024-01248-7 · Cited by 6 · see citing works

The paradoxical role of SERPINB5 in gastrointestinal cancers: oncogene or tumor suppressor?

Zeng, S., Zhang, J., Wu, J., et al. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10293-w · Cited by 5 · see citing works

Modeling Aberrant Angiogenesis in Arteriovenous Malformations Using Endothelial Cells and Organoids for Pharmacological Treatment

Oh, E. J., Kim, H. M., Kwak, S., et al. (2025) · Cells · doi:10.3390/cells14141081 · Cited by 5 · see citing works

Generation of an Isogenic Hereditary Hemorrhagic Telangiectasia Model via Prime Editing in Human Induced Pluripotent Stem Cells

Kim, M. W., Jeong, K. S., Kim, J., Lee, S.-G., Kim, C., & Chung, H. (2024) · International Journal of Stem Cells · doi:10.15283/ijsc24084 · Cited by 4 · see citing works