Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering
Open accessAbstract
Vascularization of micro-tissues in vitro has enabled formation of tissues larger than those limited by diffusion with appropriate nutrient/gas exchange as well as waste elimination. Furthermore, angiocrine signaling from the vasculature may be essential in mimicking organ-level functions in these micro-tissues. In drug screening applications, the presence of an appropriate blood-organ barrier in the form of a vasculature and its supporting cells (pericytes, appropriate stromal cells) may be essential to reproducing organ-scale drug delivery pharmacokinetics. Cutting-edge techniques including 3D bioprinting and in vitro angiogenesis and vasculogenesis could be applied to vascularize a range of tissues and organoids. Herein, we describe the latest developments in vascularization and prevascularization of micro-tissues and provide an outlook on potential future strategies.
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The recapitulation of more realistic vascularization demands the use of more sophisticated microfabrication techniques.
“The recapitulation of more realistic vascularization demands the use of more sophisticated microfabrication techniques [181].”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [181]
The In vitro vascularization section describes 3D printing and microfluidic approaches for creating vascular networks, while noting that current 3D printing cannot produce the smallest capillaries. The Future outlook says advances in bioprinting and biomaterials are likely to improve reproduction of complex in vivo tissues. It does not say that more realistic vascularization demands more sophisticated microfabrication techniques specifically; it also describes angiogenesis and vasculogenesis as routes to fine capillary structures. (LLM, conf=0.83)
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- Authors
- Osaki, T., Sivathanu, V., & Kamm, R. D.
- Affiliations
- Massachusetts Institute of Technology (US)
- Singapore-MIT Alliance for Research and Technology (SG)
- Corresponding author
- Kamm, Roger D
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 52
- Pages
- 116-123
- ISSN
- 0958-1669 (ISSN-L)
- PMC
- PMC6082713
- OpenAlex
- W2797015192
- Cited by
- 141
- References
- 64
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 17 · 2023: 18 · 2022: 24 · 2021: 16 · 2020: 16 · 2019: 16 · 2018: 3
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 254 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Opinion in Biotechnology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (CBET-0939511)
- JSPS (Japan Society for the Promotion of Science)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- organ-on-a-chip, vascularization, microfluidics, drug screening, disease models, tissue engineering, angiogenesis, vasculogenesis, 3D bioprinting, organoids, pericytes, angiocrine signaling, pharmacokinetics, prevascularization
- MeSH terms
- Drug Evaluation, Preclinical, Humans, Organ Specificity, Neovascularization, Physiologic, Tissue Engineering, Microfluidics, Bioprinting
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