DermAll nanomedicine for allergen-specific immunotherapy
Open accessAbstract
Allergen-specific immunotherapy (ASIT) the only disease-modifying treatment for IgE-mediated allergies is characterized with long treatment duration and high risk of side effects. We investigated the safety, immunogenicity and efficacy of a novel ASIT, called DermAll, in an experimental allergic rhinitis model. We designed and characterized DermAll-OVA, a synthetic plasmid pDNA/PEIm nanomedicine expressing ovalbumin (OVA) as model allergen. DermAll-OVA was administered topically with DermaPrep device to target Langerhans cells. To detect the clinical efficacy of DermAll ASIT we quantified the nasal symptoms and characterized the immunomodulatory activity of DermAll ASIT by measuring cytokine secretion after OVA-stimulation of splenocytes and antibodies from the sera. In allergic mice DermAll ASIT was as safe as Placebo, balanced the allergen-induced pathogenic TH2-polarized immune responses, and decreased the clinical symptoms by 52% [32%, 70%] compared to Placebo. These studies suggest that DermAll ASIT is safe and should significantly improve the immunopathology and symptoms of allergic diseases.From the clinical editor A novel allergen-specific immunotherapy for IgE-mediated allergies is presented in this paper, using an experimental allergic rhinitis model and a synthetic plasmid pDNA/PEIm nanomedicine expressing ovalbumin as model allergen. Over 50% reduction of symptoms was found as the immune system's balance was favorably altered toward more TH2-polarized immune responses.
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Epicutaneous immunotherapy has been investigated in a mouse model using nanoparticles containing allergen-encoding DNA.
“Epicutaneous immunotherapy has recently been investigated in a mouse model using nanoparticles containing an allergen encoding DNA.1710”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [1710]
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- Authors
- Garaczi, E., Szabó, K., Francziszti, L., Csiszovszki, Z., Lőrincz, O., Tőke, E. R., Molnár, L., Bitai, T., Jánossy, T., Bata-Csörgő, Z., Kemény, L., & Lisziewicz, J.
- Affiliations
- University of Szeged (HU)
- Corresponding author
- Kemény, Lajos
- ORCID
- Venue
- Nanomedicine: Nanotechnology, Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 9
- Issue
- 8
- Pages
- 1245-1254
- ISSN
- 1549-9634 (ISSN-L)
- OpenAlex
- W2048218063
- Cited by
- 12
- References
- 34
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2020: 3 · 2018: 1 · 2017: 2 · 2014: 1 · 2013: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (submittedVersion, other-oa)
- Funders
- Nemzeti Kutatási és Technológiai Hivatal
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- allergen immunotherapy, nanomedicine, ovalbumin, experimental allergic rhinitis, IgE-mediated allergy, Langerhans cells, topical immunotherapy, Th1/Th2 balance, cytokine production, immunomodulation
- MeSH terms
- Administration, Topical, Allergens, Animals, Female, Immunoglobulin E, Immunization, Langerhans Cells, Mice, Inbred BALB C, Ovalbumin, Plasmids, Rhinitis, Allergic, Perennial, Cytokines, Th2 Cells, Vaccines, DNA, Nanomedicine, Mice, Rhinitis, Allergic
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