Cited by 30RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers

Smart nanoparticles assembled by endogenous molecules for siRNA delivery and cancer therapy via CD44 and EGFR dual-targeting

Open access
Liang, Yaoyao, Peng, Jiahui, Li, Ning, Yu-Wai-Man, Cynthia, Wang, Qian, Xu, Yuhong, Wang, Hongxia, Tagalakis, Aristides D. +1 more·2019·Nanomedicine Nanotechnology Biology and Medicine

Abstract

We developed an anticancer siRNA delivery system (named HLPR) through modular assembly of endogenous molecules. The structure of HLPR was a tightly condensed siRNA-peptide inner core in turn surrounded by the disordered lipid layer and thin HA coating from which the EGFR-targeted amino acid sequences of YHWYGYTPQNVI partially protrude outside of cell surfaces. Both HA and YHWYGYTPQNVI anchored on HLPR were responsible for targeting CD44 and EGFR overexpressed on the tumor cell surfaces, respectively. HLPR was relatively stable in the blood circulation and reached the tumor tissue in vivo through passive and active targeting. Then HLPR entered tumor cells mainly through EGFR-mediated pathway followed by the separation of HA from the remaining parts of nanocomplexes. The HA-uncoated complexes escaped the endosome through the membrane fusion function of DOPE and released cargoes (siRNA and peptide/siRNA) in the cytoplasm. HLPR significantly inhibited the growth of implanted subcutaneous liver tumors without toxicity.

Integrity signals

Registry

Crossref · 10.1016/j.nano.2018.09.018

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Liang, Y., Peng, J., Li, N., Yu-Wai-Man, C., Wang, Q., Xu, Y., Wang, H., Tagalakis, A. D., & Du, Z.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Edge Hill University (GB)
Corresponding author
  • Wang, Hongxia
  • Du, Zixiu
Venue
Nanomedicine Nanotechnology Biology and Medicine
Publisher
Elsevier BV
Published
2019-01
Volume
15
Issue
1
Pages
208-217
ISSN
1549-9634 (ISSN-L)
OpenAlex
W2897401086
Cited by
30
References
38
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 4
FWCI
1.43
Type
journal article
Language
en
Open access
Locations
  • Nanomedicine Nanotechnology Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Edge Hill University (submittedVersion)
  • Edge Hill University Research Information Repository (Edge Hill University) (submittedVersion, cc-by-nc-nd)
Funders
  • National Natural Science Foundation of China (81690262)
  • Engineering and Medical Cooperation Projects of Shanghai Jiao Tong University (YG2016MS22)
  • Minhang “Production-Study-Research” Project in Shanghai (2016MH229)
  • Development Fund for Shanghai Talents (2017111)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords
siRNA delivery, nanoparticles, CD44 targeting, EGFR targeting, dual targeting, hyaluronic acid coating, peptide ligands, tumor targeting, endosomal escape, membrane fusion, liver tumors, cancer therapy
MeSH terms
Animals, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Tumor Cells, Cultured, Drug Delivery Systems, Apoptosis, Hyaluronan Receptors, Xenograft Model Antitumor Assays, RNA, Small Interfering, Cell Proliferation, Mice, Nanoparticles, ErbB Receptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review