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Reprogramming the pancreatic cancer stroma and immune landscape by a silicasome nanocarrier delivering nintedanib, a protein tyrosine kinase inhibitor
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“Nintedanib silicasome | Tyrosine-kinase inhibitor delivery; vessel pruning; collagen reduction; immune reprogramming | Orthotopic pancreatic cancer (mouse) | Abnormal tumor vasculature and stromal fibrosis | Tumor tissue (24 h): nintedanib quantified by HPLC (20.82 μg·g⁻1) | — | [45]”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [45]
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“A silicasome that delivers the multi-target TKI nintedanib increases intratumoral drug exposure, prunes aberrant vessels, reduces collagen, elevates the CD8⁺/FoxP3⁺ ratio, and enables synergy with anti-PD-1 in a robust orthotopic pancreatic cancer model [45]”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [45]
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Cites
Nintedanib in Progressive Fibrosing Interstitial Lung Diseases
Flaherty, K. R., Wells, A. U., Cottin, V., Devaraj, A., Walsh, S. L. F., Inoue, Y., Richeldi, L., Kolb, M., Tetzlaff, K., Stowasser, S., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1908681 · Cited by 2,403
Raghu, G., Rochwerg, B., Zhang, Y., Garcia, C. A. C., Azuma, A., Behr, J., Brozek, J. L., Collard, H. R., Cunningham, W., Homma, S., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201506-1063st · Cited by 1,916
Chauhan, V. P., Martin, J. D., Liu, H., Lacorre, D. A., Jain, S. R., Kozin, S. V., Stylianopoulos, T., Mousa, A. S., Han, X., Adstamongkonkul, P., et al. (2013) · Nature Communications · doi:10.1038/ncomms3516 · Cited by 1,031
Pancreatic cancer stroma: an update on therapeutic targeting strategies
Hosein, A. N., Brekken, R. A., & Maitra, A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0300-1 · Cited by 950
Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance
Aksamitiene, E., Kiyatkin, A., & Kholodenko, B. N. (2012) · Biochemical Society Transactions · doi:10.1042/bst20110609 · Cited by 479
Aguilera, K. Y., Huang, H., Du, W., Hagopian, M. M., Wang, Z., Hinz, S., Hwang, T. H., Wang, H., Fleming, J. B., Castrillon, D. H., et al. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0834 · Cited by 118
Research works printed but not linked: 42
- Siegel, 2023, Cancer statistics, 2023, CA Cancer J. Clin., 73, 17
- Erkan, 2012, The role of stroma in pancreatic cancer: diagnostic and therapeutic implications, Nat. Rev. Gastroenterol. Hepatol., 9, 454, 10.1038/nrgastro.2012.115 · DOI · Paper page
- Meng, 2018, Use of nano engineered approaches to overcome the stromal barrier in pancreatic cancer, Adv. Drug Deliv. Rev., 130, 50, 10.1016/j.addr.2018.06.014 · DOI
- Liu, 2022, Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies, Theranostics, 12, 1030, 10.7150/thno.64805 · DOI
- Ortíz, 2021, Nanomedicine to overcome multidrug resistance mechanisms in colon and pancreatic cancer: recent progress, Cancers, 13, 2058, 10.3390/cancers13092058 · DOI
- Nel, 2022, Multifunctional lipid bilayer nanocarriers for cancer immunotherapy in heterogeneous tumor microenvironments, combining immunogenic cell death stimuli with immune modulatory drugs, ACS Nano, 16, 5184, 10.1021/acsnano.2c01252 · DOI
- Frampton, 2020, Liposomal irinotecan: a review in metastatic pancreatic adenocarcinoma, Drugs, 80, 1007, 10.1007/s40265-020-01336-6 · DOI
- Von Hoff, 2013, Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine, N. Engl. J. Med, 369, 1691, 10.1056/NEJMoa1304369 · DOI · Paper page
- Liu, 2017, Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer, J. Clin. Invest, 127, 2007, 10.1172/JCI92284 · DOI
- Liu, 2016, Irinotecan delivery by lipid-coated mesoporous silica nanoparticles shows improved efficacy and safety over liposomes for pancreatic cancer, ACS Nano, 10, 2702, 10.1021/acsnano.5b07781 · DOI
- Liu, 2019, Improved efficacy and reduced toxicity using a custom-designed irinotecan-delivering silicasome for orthotopic colon cancer, ACS Nano, 13, 38, 10.1021/acsnano.8b06164 · DOI
- Liu, 2021, Combination chemo-immunotherapy for pancreatic cancer using the immunogenic effects of an irinotecan silicasome nanocarrier plus Anti-PD-1, Adv. Sci., 8
- Luo, 2022, Nanocarrier Co-formulation for Delivery of a TLR7 Agonist plus an Immunogenic Cell Death Stimulus Triggers Effective Pancreatic Cancer Chemo-immunotherapy, ACS Nano, 10.1021/acsnano.2c06300 · DOI
- Lakkakula, 2019, Small molecule tyrosine kinase inhibitors and pancreatic cancer—Trials and troubles, Semi. Cancer Bio, 56, 149, 10.1016/j.semcancer.2018.09.011 · DOI
- Fujimoto, 1998, Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer, and its relationship to angiogenesis, Eur. J. Cancer, 34, 1439, 10.1016/S0959-8049(98)00069-0 · DOI
- Ohta, 1995, Expression of basic fibroblast growth factor and its receptor in human pancreatic carcinomas, Br. J. Cancer, 72, 824, 10.1038/bjc.1995.420 · DOI
- Hilberg, 2008, BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy, Cancer Res, 68, 4774, 10.1158/0008-5472.CAN-07-6307 · DOI · Paper page
- Fala, 2015, Ofev (Nintedanib): first tyrosine kinase inhibitor approved for the treatment of patients with idiopathic pulmonary fibrosis, Am. Health Drug Benefits, 8, 101
- Tu, 2022, Nintedanib enhances the efficacy of PD-L1 blockade by upregulating MHC-I and PD-L1 expression in tumor cells, Theranostics, 12, 747, 10.7150/thno.65828 · DOI
- Wind, 2019, Clinical Pharmacokinetics and Pharmacodynamics of Nintedanib, Clin. Pharmacokinet., 58, 1131, 10.1007/s40262-019-00766-0 · DOI
- Allen, 2021, Immune checkpoint inhibition in syngeneic mouse cancer models by a silicasome nanocarrier delivering a GSK3 inhibitor, Biomaterials, 269, 10.1016/j.biomaterials.2020.120635 · DOI
- Hibi, 2016, FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib, Cancer Sci., 107, 1667, 10.1111/cas.13071 · DOI
- Jain, 2005, Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy, Science, 307, 58, 10.1126/science.1104819 · DOI · Paper page
- Kato, 2021, Nintedanib promotes antitumour immunity and shows antitumour activity in combination with PD-1 blockade in mice: potential role of cancer-associated fibroblasts, Br. J. Cancer, 124, 914, 10.1038/s41416-020-01201-z · DOI
- Wang, 2018, Regulation of PD-L1: Emerging Routes for Targeting Tumor Immune Evasion, Front. Pharm., 9
- Wu, 2019, PD-L1 Distribution and Perspective for Cancer Immunotherapy—Blockade, Knockdown, or Inhibition, Front. Immunol., 10, 10.3389/fimmu.2019.02022 · DOI
- Yi, 2021, Regulation of PD-L1 expression in the tumor microenvironment, J. Hematol. Oncol., 14, 10, 10.1186/s13045-020-01027-5 · DOI · Paper page
- Awasthi, 2015, Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer, Cancer Lett., 358, 59, 10.1016/j.canlet.2014.12.027 · DOI
- Li, 2020, Overcoming therapeutic failure in osteosarcoma via Apatinib-encapsulated hydrophobic poly(ester amide) nanoparticles, Biomater. Sci., 8, 5888, 10.1039/D0BM01296C · DOI · Paper page
- Lu, 2019, Afatinib-loaded immunoliposomes functionalized with cetuximab: A novel strategy targeting the epidermal growth factor receptor for treatment of non-small-cell lung cancer, Int. J. Pharm., 560, 126, 10.1016/j.ijpharm.2019.02.001 · DOI
- Gao, 2019, Preparation and evaluation of folate-decorated human serum albumin nanoparticles for the targeted delivery of sorafenib to enhance antihepatocarcinoma efficacy, J. Drug Deliv. Sci. Technol., 54
- Blair, 2019, Dissecting the Stromal Signaling and Regulation of Myeloid Cells and Memory Effector T Cells in Pancreatic Cancer, Clin. Cancer Res, 25, 5351, 10.1158/1078-0432.CCR-18-4192 · DOI
- Zinger, 2019, Collagenase nanoparticles enhance the penetration of drugs into pancreatic tumors, ACS Nano, 13, 11008, 10.1021/acsnano.9b02395 · DOI
- Peng, 2022, Local release of TGF-β inhibitor modulates tumor-associated neutrophils and enhances pancreatic cancer response to combined irreversible electroporation and immunotherapy, Adv. Sci., 9, 10.1002/advs.202105240 · DOI
- Massó-Vallés, 2015, Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma, Cancer Res, 75, 1675, 10.1158/0008-5472.CAN-14-2852 · DOI
- Jain, 2001, Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy, Nat. Med., 7, 987, 10.1038/nm0901-987 · DOI · Paper page
- Carmeliet, 2011, Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases, Nat. Rev. Drug Discov., 10, 417, 10.1038/nrd3455 · DOI
- Hosein, 2020, Pancreatic cancer stroma: an update on therapeutic targeting strategies, Nat. Rev. Gastroenterol. Hepatol., 17, 487, 10.1038/s41575-020-0300-1 · DOI · Paper page
- Huang, 2012, Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy, Proc. Natl. Acad. Sci., 109, 17561, 10.1073/pnas.1215397109 · DOI · Paper page
- Batchelor, 2013, Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation, Proc. Natil. Acad. Sci., 110, 19059, 10.1073/pnas.1318022110 · DOI
- Matsumoto, 2011, Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia, Cancer Res, 71, 6350, 10.1158/0008-5472.CAN-11-2025 · DOI
- Tsukita, 2019, Beneficial effects of sunitinib on tumor microenvironment and immunotherapy targeting death receptor5, OncoImmunology, 8, 10.1080/2162402X.2018.1543526 · DOI
Cited by
Sorted by citations
Sheng, J., Yuan, W., Zhang, M., Chen, Z., Qi, Y., Zhao, Y., & Zhang, S. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04028-7 · Cited by 35
Metadata
- Authors
- Luo, L., Wang, X., Liao, Y.-P., Xu, X., Chang, C. H., & Nel, A. E.
- Venue
- Nano Today
- Publisher
- Elsevier BV
- Published
- 2024-02
- Volume
- 54
- Pages
- 102058
- ISSN
- 1748-0132
- Cited by
- 16
- References
- 6
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 288 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Funders
- U.S. Public Health Service (R01CA247666–03)
- California NanoSystems Institute
- National Cancer Institute
- University of California, Los Angeles
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- CoChat. (2026). Citation check: Reprogramming the pancreatic cancer stroma and immune landscape by a silicasome nanocarrier delivering nintedanib, a protein tyrosine kinase inhibitor. https://app.cochat.ai/papers/10.1016/j.nantod.2023.102058
- The paper
- Luo, L., Wang, X., Liao, Y.-P., Xu, X., Chang, C. H., & Nel, A. E. (2024). Reprogramming the pancreatic cancer stroma and immune landscape by a silicasome nanocarrier delivering nintedanib, a protein tyrosine kinase inhibitor. Nano Today. https://doi.org/10.1016/j.nantod.2023.102058