Depression-like phenotype following chronic CB1 receptor antagonism
Beyer, Chad E., Dwyer, Jason M., Piesla, Michael J., Platt, Brian J., Shen, Ru, Rahman, Zia, Chan, Karen, Manners, Melissa T., Samad, Tarek A., Kennedy, Jeffrey D., Bingham, Brendan, Whiteside, Garth T.·2010·Neurobiology of Disease
Cited by (159)
Items 101–159 of 159
- The Endocannabinoid System as a Biomarker for Diagnostic and Therapeutic Applications in Depression and AnxietyEric Murillo‐Rodríguez, Jocelyne Alcaraz-Silva, Daniel Feingold, Gerardo Viana-Torre, Henning Budde, Claudio Imperatori, Sergio Eduardo de Carvalho Machado · 2022 · CNS & Neurological Disorders - Drug Targets
- - Role of the Endocannabinoid System in the Neurobiology of SuicideYogesh Dwivedi · 2012 · CRC Press eBooks
- Effects of pro‐depressant and immunomodulatory drugs on biases in decision‐making in the rat judgement bias taskClaire A. Hales, Julia M. Bartlett, Roberto Arban, Bastian Hengerer, Emma S. J. Robinson · 2021 · European Journal of Neuroscience
- Effects of the antipsychotic paliperidone on stress-induced changes in the endocannabinoid system in rat prefrontal cortexKarina S. MacDowell, Aline Sayd, Borja García‐Bueno, Javier R. Caso, José L. M. Madrigal, Juan Carlos Leza · 2016 · The World Journal of Biological Psychiatry
- The Endocannabinoid System in Prefrontal SynaptopathiesAndrew F. Scheyer, Henry G. S. Martin, Olivier J. Manzoni · 2017 · Springer eBooks
- Brain region specific regulation of anandamide (down) and sphingosine-1-phosphate (up) in association with anxiety (AEA) and resilience (S1P) in a mouse model of chronic unpredictable mild stressCaroline Fischer, Dominique Thomas, Robert Gurke, Irmgard Tegeder · 2024 · Pflügers Archiv - European Journal of Physiology
- Modern approaches to the development of synthetic cannabinoid receptor probesSavanah L. Saldaña-Shumaker, Alexander J. Grenning, Christopher W. Cunningham · 2021 · Pharmacology Biochemistry and Behavior
- RTICBM-74 Is a Brain-Penetrant Cannabinoid Receptor Subtype 1 Allosteric Modulator that Reduces Alcohol Intake in RatsDennis F. Lovelock, Thuy Nguyen, Kalynn J. Van Voorhies, Yanan Zhang, Joyce Besheer · 2021 · Journal of Pharmacology and Experimental Therapeutics
- The associations of CNR1 SNPs and haplotypes with vulnerability and treatment response phenotypes in Han Chinese with major depressive disorder: A case–control association studyChenghao Yang, Ilja Maria Nolte, Yanyan Ma, Xuguang An, Fokko J. Bosker, Jie Li · 2021 · Molecular Genetics & Genomic Medicine
- Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic painAxel Becker, Gerd Geißlinger, Radovan Murín, Gisela Grecksch, Volker Höllt, Andreas Zimmer, Helmut Schröder · 2013 · Naunyn-Schmiedeberg s Archives of Pharmacology
- Animal Models of Risk Factors for Suicidal Ideation and BehaviourSarah A. Stuart, Paul Butler, Emma S. J. Robinson · 2014 · Springer eBooks
- The role of cannabinoid-mediated signaling pathways and mechanisms in brain disordersShunfeng Liu, Zegang Ma · 2025 · Cellular Signalling
- Depression Onset in Long-term Adolescent Cannabinoid Use: A Neurobiological ReviewShawn Y Forrester, Nusrat Jahan · 2020 · Cureus
- CB1 Receptor Silencing Attenuates Ketamine-Induced Hyperlocomotion Without Compromising Its Antidepressant-Like EffectsPedro Henrique Gobira, Jacob LaMar, J. S. Marques, Ariandra Guerini Sartim, Kennia Moura Silveira, Luana Oliveira dos Santos, Gregers Wegener, Francisco Silveira Guimarães, Ken Mackie, Hui‐Chen Lu et al. · 2022 · Cannabis and Cannabinoid Research
- Dopamine, activation of ingestion and evaluation of response efficacy: a focus on the within-session time-course of licking burst numberPaolo S. D’Aquila · 2024 · Psychopharmacology
- CB1 receptor signaling: Linking neuroplasticity, neuronal types, and mental health outcomesQianqian Gao, Muhammad Asim · 2025 · Neurochemistry International
- Disease‐associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue‐specific activity of the cannabinoid‐1 receptor gene promoter; implications for cannabinoid pharmacogeneticsElizabeth A. Hay, Philip Cowie, Andrew R. McEwan, Ruth A. Ross, Roger G. Pertwee, Alasdair MacKenzie · 2019 · Human Mutation
- Pharmacological comparison of traditional and non-traditional cannabinoid receptor 1 blockers in rodent models in vivoBalázs Varga, Ferenc Kassai, György Szabó, Péter Kovács, János Fischer, István Gyertyán · 2017 · Pharmacology Biochemistry and Behavior
- Optimization of the Heterologous Expression of the Cannabinoid Type-1 (CB1) ReceptorViktória Bea Horváth, Eszter Soltész‐Katona, Éva Wisniewski, Anikó Rajki, Eszter Halász, Balázs Enyedi, László Hunyady, András Dávid Tóth, Gergő Szanda · 2021 · Frontiers in Endocrinology
- Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 ReceptorCaitlin E. Scott, Kwang H. Ahn, Steven T. Graf, William A. Goddard, Debra A. Kendall, Ravinder Abrol · 2015 · Journal of Chemical Information and Modeling
- Endocannabinoid system in trauma and psychosis: distant guardian of mental stabilityTomasz Bielawski, Lucas Albrechet‐Souza, Dorota Frydecka · 2021 · Reviews in the Neurosciences
- Role of the Endocannabinoid System in the Neurobiology of SuicideK Vinod · 2012 · Frontiers in neuroscience
- Considerations on nonclinical approaches to modeling risk factors of suicidal ideation and behaviorSusan M.G. Goody, Kerena Cannon, M. Liu, Mary Jeanne Kallman, Jean-Pierre Martinolle, Ludmilla Mazelin-Winum, Alessandra Giarola, Paul A. Ardayfio, John A. Moyer, Greet Teuns et al. · 2017 · Regulatory Toxicology and Pharmacology
- Neural Receptors Associated with Depression: A Systematic Review of the Past 10 YearsAlice Barros Câmara, Igor Augusto Brandão · 2020 · CNS & Neurological Disorders - Drug Targets
- Combined administration of intracerebroventricular CB1 agonist ACEA and systemic TRPV1 agonist capsaicin induces synergistic antidepressant-like effects in ratsDaniela A. Avalos-Moreno, Sergio Guillermo Cuevas-Carbonell, Metzli E. Ramírez-Vargas, Luis Castro‐Sánchez, Adolfo Virgen‐Ortiz, Enrique Alejandro Sánchez-Pastor, José Luis Góngora-Alfaro, Ricardo A. Navarro‐Polanco, Eloy Gerardo Moreno-Galindo, Javier Alamilla · 2026 · Behavioural Brain Research
- The chronic pharmacological antagonism of the CB1 receptor is not involved in the behavioral effects of antidepressants administered in mice submitted to chronic unpredictable stressMelissa A. Ribeiro, Rafael Pazinatto Aguiar, Franciele Franco Scarante, Eduardo Junji Fusse, Rúbia Maria Weffort de Oliveira, Francisco Silveira Guimarães, Alline Cristina Campos · 2023 · Behavioural Brain Research
- Chronic CB1 cannabinoid receptor antagonism persistently increases dendritic spine densities in brain regions important to zebra finch vocal learning and production in an antidepressant-sensitive mannerTessa L. Holland, Ken Soderstrom · 2017 · Brain Research
- Microstructure analysis of the effects of the cannabinoid agents HU-210 and rimonabant in rats licking for sucrosePaolo S. D’Aquila · 2020 · European Journal of Pharmacology
- Genetic, epigenetic and pharmacological influences modulating tissue specific regulation of the cannabinoid receptor-1 gene (CB 1 ); implications for cannabinoid pharmacogeneticsElizabeth A. Hay, Philip Cowie, Andrew R. McEwan, Dana Wilson, Ruth A. Ross, Perry Barrett, Roger G. Pertwee, Alasdair MacKenzie · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Synthesis and Biological Evaluation of Pyrrolo[2,3-d]pyrimidine Derivatives as Novel Apoptotic Agents for Human Lung Cancer CellsK. M. H. HILMY, Fawzya N. M. Kishk, Esmat B. A. Shahen, Mohamed A. Hawata · 2023 · Russian Journal of Organic Chemistry
- Endocannabinoid-mediated regulation of depression in the ovBNSTRiming Zhu, Jie Li, Xia Zhang, Bin Zhang · 2025 · Frontiers in Neuroscience
- Cannabinoid treatment impacts adaptive behavior in autism patients and caregivers’ mental health: A prospective real-life cohort studyKelly Álvares Guimarães, Letícia Perígolo Jorge, Ana Luiza de Oliveira Resende, Estácio Amaro da Silva, Arthur Kümmer, Wilson A. Silva, Guilherme Nogueira Mendes de Oliveira · 2025 · Progress in brain research
- Endocannabinoids, Stress, and Negative AffectAnthony L. Berger, Angela M. Henricks, Matthew N. Hill, Ryan J. McLaughlin · 2017 · Springer eBooks
- Au delà des antidépresseurs sérotoninergiques? Nouvelles stratégies pharmacologiques, · 2012 · Schweizer Archiv für Neurologie und Psychiatrie
- Have the Genetics of Cannabis Involvement Gone to Pot?Arpana Agrawal A, Michael T. Lynskey · 2014 · Nebraska Symposium on Motivation/The Nebraska symposium on motivation
- Endocannabinoid Metabolism in Posttraumatic Stress Disorder: Results From a Neuroimaging Study With the Novel Fatty Acid Amide Hydrolase Probe, [C-11] CurbErin V. Gaudette, Sarah E. Watling, Jerry J. Warsh, Tina McCluskey, Junchao Tong, Sylvain Houle, Pablo Rusjan, Shawn G. Rhind, Richard Paul Bazinet, Rachel Fynvola Tyndale et al. · 2020 · Biological Psychiatry
- Adolescent CB1 receptor expression at the BLA and CA1 and acute AM251 effects on sociability and emotional memory are sex-specific, and not modulated by heterotypic stress exposureEmmanuelle Person, Hélène Plamondon · 2025 · Behavioural Brain Research
- Anhedonia in Mouse Models of Methamphetamine-Induced Drug Seeking BehaviorJunichi Kitanaka, Nobue Kitanaka, Frank Scott Hall, George R. Uhl, Motohiko Takemura · 2014 · Springer eBooks
- UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CIÊNCIAS BIOLÓGICAS DEPARTAMENTO DE FARMACOLOGIA PROGRAMA DE PÓS-GRADUAÇÃO EM FARMACOLOGIA MODULAÇÃO DO COMPORTAMENTO DE RATOS SUBMETIDOS AO TESTE DO NADO FORÇADO PELO RECEPTOR VANILÓIDE DE POTENCIAL TRANSITÓRIO TIPO 1 DO HIPOCAMPOAna Carolina Vanvossen · 2012
- Nicotine Reward and Abstinence: Role of the CB1 ReceptorsSalma Tannous, Stéphanie Caillé · 2019 · Elsevier eBooks
- Characterizing chronic non-suicidal self-injury and other forms of repetitive and escalating suicide behaviour as endocannabinoid-mediated pain and reward disordersHye Ji J. Kim, David A. Petrishen, Robert B. Laprairie, Evyn M. Peters · 2022 · Personalized Medicine in Psychiatry
- DepressionKylie O’Brien, Philip Blair · 2021 · Springer eBooks
- Discriminative stimulus properties of 3-substituent rimonabant analogsD. Matthew Walentiny · 2011 · VCU Scholars Compass (Virginia Commonwealth University)
- Rimonabant: a CB1 receptor antagonist as a direct interactional partner for μ- and δ-opioid receptorFerenc Zádor · 2014
- POSSIBLE EFFECTS OF THE ENDOCANNABINOID SYSTEM ON THE PATHOPHYSIOLOGY OF DEPRESSION: MEDICAL TREATMENT APPROACHES BASED ON THIS SYSTEMRavza Nazlı Müyesseroğlu, Oğuzhan Yıldız · 2023 · TURKISH MEDICAL STUDENT JOURNAL
- Mood, Motivation, and Mental HealthJean-Paul Henri Dedam, Matthew Fogel, Elizabeth Fogel · 2025 · Springer eBooks
- Associations between cannabis use frequency and suicidal thoughts and behaviors: A clinical longitudinal sibling studyElisa F. Stern, Jarrod M. Ellingson, Jonathan D. Schaefer, Jesse D. Hinckley, Michael C. Stallings, Robin P. Corley, Christian Jean Hopfer, Tamara L. Wall, Soo Hyun Rhee · 2025 · Addictive Behaviors Reports
- Neurensin-2 is a negative regulator of CB1 receptorYumna Abu Ghanem, Liora Dorfman-Yahad, Hadas Catane Hovav, Laila Agbariya, Adi Cohen, Hila Yehuda, Gali Umschweif · 2025 · Biochemical Pharmacology
- Modulation of Serotonin Firing Activity Through CB1 Agonists and FAAH InhibitorsGabriella Gobbi · 2013 · Springer eBooks
- Peripheral CB1R inhibition modulates food intake and metabolic efficiency in obesity independently of the gut-brain vagal axisOriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge H. Luquet, Giuseppe Gangarossa · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Impact of CBG deficiency on emotional and cognitive processesGabriela Ferreira de Medeiros · 2016 · theses.fr (ABES)
- Déficits synaptiques et comportementaux des voies méso-cortico-limbiques induits par le cannabis ou un déséquilibre alimentaire en acides gras polyinsaturésAnissa Bara · 2017 · theses.fr (ABES)
- Evaluating the cannabinoid CB1 receptor as a therapeutic target in a Shank3 mouse model of autism and Phelan-McDermid syndromeFlavio Tomasi · 2023 · theses.fr (ABES)
- Cellular and Behavioral Interactions of Cannabinoid and Opioid Systems in Pain, Mood, Reward, and AddictionAida Mohammadkhani, Colleen S. Peterson, Stephanie L. Borgland · 2026 · Springer eBooks
- Communication in the Depressed BrainFranklin Sunzeri · 2026 · Springer eBooks
- Inhibition of peripheral CB 1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axisOriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge H. Luquet, Giuseppe Gangarossa · 2026 · British Journal of Pharmacology
- Muscone Exerts Rapid Antidepressant Effects Through Modulating Glutamatergic Neural Transmission in the Anterior Cingulate Cortex Against Peripheral Inflammation-induced DepressionXiaoyun Qiu, Xiaojie Zhang, Yuanzhi Yang, Minjuan Sun, Xiaoli Da, Jiaying Liu, Rui Wang, Jingjia Liang, Xuhong Jiang, Gang Tian et al. · 2026 · Neuroscience Bulletin
- DepressionKylie O’Brien, Philip Blair · 2026 · Springer eBooks
- CARDIOPROTECTIVE EFFECT OF THE CB1 RECEPTOR LIGAND HEMOPRESSIN ON DOXORUBICIN-INDUCED CARDIOTOXICITY IN RATS: A SCINTIGRAPHIC, ELECTROCARDIOGRAPHIC, AND BIOCHEMICAL STUDYReyhan Köroğlu, Hatice Aygün · 2026 · Kocatepe Tıp Dergisi