Depression-like phenotype following chronic CB1 receptor antagonism
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Rimonabant was the first clinically marketed cannabinoid (CB)(1) receptor antagonist developed to treat obesity. Unfortunately, CB(1) receptor antagonism produced adverse psychiatric events in patients. To determine whether this occurs pre-clinically, we investigated the effects of rimonabant in rodent models of mood disorders. Chronic treatment with rimonabant increased immobility time in the rat forced swim test and reduced the consumption of sucrose-sweetened water in an assay postulated to model anhedonia. These responses were similar to the effects elicited by chronic mild stress in these behavioral models, which, taken together, are indicative of a depression-like phenotype. Additionally, chronic treatment with rimonabant produced decreases in frontal cortex serotonin levels, marked reductions in hippocampal cell proliferation, survival, and BDNF levels, and elevations in the concentrations of pro-inflammatory cytokines including interferon gamma and TNF alpha. These preclinical findings mimic clinical reports and implicate possible mechanisms responsible for the unfavorable psychiatric events reported following chronic rimonabant use.
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Down-regulation of CB1 receptors may result in a depression-like phenotype in certain individuals and increase risk of addiction.
“which may in turn result in a depression-like phenotype in certain individuals54 and increase risk of addiction55.”
From Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study (2013) · cites this paper as [54]
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
Christensen, R., Kristensen, P. K., Bartels, E. M., Bliddal, H., & Astrup, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61721-8 · Cited by 1,097 · see citing works
Drug treatments for obesity: orlistat, sibutramine, and rimonabant
Padwal, R. S., & Majumdar, S. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60033-6 · Cited by 753 · see citing works
Endocannabinoid control of food intake and energy balance
Marzo, V. D., & Matias, I. (2005) · Nature Neuroscience · doi:10.1038/nn1457 · Cited by 746 · see citing works
Involvement of CB1 cannabinoid receptors in emotional behaviour
Martín, M., Ledent, C. A., Parmentier, M., Maldonado, R. J., & Valverde, O. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0946-5 · Cited by 507 · see citing works
Cytokines as mediators of depression: what can we learn from animal studies?
Dunn, A. J., Swiergiel, A. H., & Beaurepaire, R. D. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.023 · Cited by 459 · see citing works
Taliaz, D., Stall, N., Dar, D. E., & Zangen, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.67 · Cited by 454 · see citing works
Bambico, F. R., Katz, N., Debonnel, G., & Gobbi, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1636-07.2007 · Cited by 325 · see citing works
Navarro, M., Hernández, E., Muñoz, R. M., del Arco, I., Villanúa, M. Á., Carrera, M. R. A., & de Fonseca, F. R. (1997) · Neuroreport · doi:10.1097/00001756-199701200-00023 · Cited by 306 · see citing works
Rinaldi, M. L., Barth, F., Héaulme, M., Alonso, R., Shire, D. J., Congy, C., Soubrié, P., Brelière, J.-C., & Fur, G. L. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00174-5 · Cited by 303 · see citing works
Bekris, S., Antoniou, K., Daskas, S., & Papadopoulou-Daifoti, Z. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.01.005 · Cited by 281 · see citing works
Peripheral mechanisms of pain and analgesia
Stein, C., Clark, J. D., Oh, U., Vasko, M. R., Wilcox, G. L., Overland, A. C., Vanderah, T. W., & Spencer, R. H. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.017 · Cited by 268 · see citing works
Griebel, G., Stemmelin, J., & Scatton, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.032 · Cited by 253 · see citing works
Neuroendocrine and cytokine profile of chronic mild stress-induced anhedonia
Grippo, A. J., Francis, J., Beltz, T. G., Felder, R. B., & Johnson, A. K. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.02.011 · Cited by 233 · see citing works
The obesity pipeline: current strategies in the development of anti-obesity drugs
Cooke, D., & Bloom, S. R. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2136 · Cited by 212 · see citing works
Behavioral and cardiovascular changes in the chronic mild stress model of depression
Grippo, A. J., Beltz, T. G., & Johnson, A. K. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00050-7 · Cited by 198 · see citing works
Janero, D. R., & Makriyannis, A. (2009) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210902736568 · Cited by 186 · see citing works
Differentiating antidepressants of the future: Efficacy and safety
Rosenzweig-Lipson, S. J., Beyer, C. E., Hughes, Z. A., Khawaja, X. Z., Rajarao, S. J. R., Malberg, J. E., Rahman, Z. U., Ring, R. H., & Schechter, L. E. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.07.002 · Cited by 182 · see citing works
Self-citationIncreasing hippocampal neurogenesis: a novel mechanism for antidepressant drugs
Malberg, J., & Schechter, L. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382223 · Cited by 167 · see citing works
Grippo, A. J., Beltz, T. G., Weiss, R. M., & Johnson, A. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.010 · Cited by 167 · see citing works
Huestis, M. A., Boyd, S. J., Heishman, S. J., Preston, K. L., BONNET, D., Fur, G. L., & Gorelick, D. A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0861-5 · Cited by 166 · see citing works
The Need for Bold Action to Prevent Adolescent Obesity
Brownell, K. D., Schwartz, M. B., Puhl, R. M., Henderson, K. E., & Harris, J. L. (2009) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2009.03.004 · Cited by 140 · see citing works
Melis, T., Succu, S., Sanna, F., Boi, A., Argiolas, A., & Melis, M. R. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.04.012 · Cited by 138 · see citing works
Lee, K. J., Kim, S.-J., Kim, S.-W., Choi, S.-H., Shin, Y.-C., Park, S.-H., Moon, B., Cho, E., Lee, M.-S., Choi, S.-H., et al. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.6 · Cited by 136 · see citing works
Activation of endocannabinoid transmission induces antidepressant-like effects in rats.
Adamczyk, P., Gołda, A., McCreary, A. C., Filip, M., & Przegaliński, E. (2008) · PubMed · Cited by 123 · see citing works
Serotonin Evokes Endocannabinoid Release and Retrogradely Suppresses Excitatory Synapses
Best, A. R., & Regehr, W. G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0678-08.2008 · Cited by 122 · see citing works
Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents
Rosenzweig-Lipson, S. J., Sabb, A. L., Stack, G., Mitchell, P., Lucki, I., Malberg, J. E., Grauer, S. M., Brennan, J. A., Cryan, J. F., Rizzo, S. J. S., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0710-6 · Cited by 102 · see citing works
Endocannabinoids in the Treatment of Mood Disorders: Evidence from Animal Models
Bambico, F. R., Duranti, A., Tontini, A., Tarzia, G., & Gobbi, G. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168029 · Cited by 91 · see citing works
Depression and anxiety with rimonabant
Mitchell, P. B., & Morris, M. J. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61705-x · Cited by 89 · see citing works
The cannabinoid CB 1 receptor and the endocannabinoid anandamide: possible antidepressant targets
Bambico, F. R., & Gobbi, G. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.11.1347 · Cited by 80 · see citing works
BDNF regulates neuronal sensitivity to endocannabinoids
Maison, P., Walker, D. J., Walsh, F. S., Williams, G. H., & Doherty, P. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.10.011 · Cited by 69 · see citing works
[Validation of an animal model of anhedonia, a major symptom of depression].
Moreau, J. (1997) · PubMed · Cited by 67 · see citing works
Rimonabant: A novel selective cannabinoid-1 receptor antagonist for treatment of obesity
Patel, P. N., & Pathak, R. (2007) · American Journal of Health-System Pharmacy · doi:10.2146/060258 · Cited by 63 · see citing works
Buchweitz, J. P., Karmaus, P. W. F., Williams, K. J., Harkema, J. R., & Kaminski, N. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0907618 · Cited by 55 · see citing works
Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain
Marchalant, Y., Brothers, H. M., & Wenk, G. L. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.62 · Cited by 54 · see citing works
Balu, D. T., Hodes, G. E., Hill, T. E., Ho, N., Rahman, Z. U., Bender, C. N., Ring, R. H., Dwyer, J. M., Rosenzweig-Lipson, S. J., Hughes, Z. A., et al. (2008) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2008.12.002 · Cited by 51 · see citing works
Self-citationDie Bedeutung des TNF-α-Systems für Erkrankungen des Gehirns
Himmerich, H., Berthold‐Losleben, M., & Pollmächer, T. (2009) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-0028-1109420 · Cited by 49 · see citing works
Benefits and risks of homoeopathy
Goldacre, B. M. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61706-1 · Cited by 39 · see citing works
McCulloch, M., Zhou, X., Xu, Y., Brunell, S. C., & SPEAR, L. P. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.01.020 · Cited by 22 · see citing works
Ward, S. J., Lefever, T. W., Rawls, S. M., Whiteside, G. T., & Walker, E. A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1592-6 · Cited by 15 · see citing works
Self-citationTrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
Li, Y., Luikart, B. W., Birnbaum, S. G., Chen, J., Kwon, C., Kernie, S. G., Bassel‐Duby, R., & Parada, L. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.021 · Cited by 8 · see citing works
Obesity, the Endocannabinoid System, and Bias Arising from Pharmaceutical Sponsorship
McPartland, J. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005092 · Cited by 7 · see citing works
Escitalopram has potent and rapid effect in a chronic mild stress model of depression in rats
Papp, M., & Sánchez, C. (2001) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(01)80243-1 · Cited by 2 · see citing works
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Sorted by citations
Neumeister, A., Normandin, M. D., Pietrzak, R. H., Piomelli, D., Zheng, M. Q., Gujarro-Anton, A., Potenza, M. N., Bailey, C. R., Lin, S. F., Najafzadeh, S., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.61 · Cited by 361 · see citing works
Hill, M. N., Bierer, L. M., Makotkine, I., Golier, J. A., Galea, S., McEwen, B. S., Hillard, C. J., & Yehuda, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.08.004 · Cited by 256 · see citing works
Shen, C.-J., Zheng, D., Li, K., Yang, J., Pan, H., Yu, X.-D., Fu, J., Zhu, Y., Sun, Q.-X., Tang, M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0299-9 · Cited by 223 · see citing works
Neuroimmunological effects of physical exercise in depression
Eyre, H. A., & Baune, B. T. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.015 · Cited by 188 · see citing works
Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors
Serrano, A., & Parsons, L. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.005 · Cited by 180 · see citing works
CB1 receptor-deficient mice as a model for depression
Valverde, O., & Torrens, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.031 · Cited by 153 · see citing works
Don't Worry, Be Happy: Endocannabinoids and Cannabis at the Intersection of Stress and Reward
Volkow, N. D., Hampson, A. J., & Baler, R. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104615 · Cited by 150 · see citing works
Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives
Strekalova, T. V., Liu, Y., Kiselev, D., Khairuddin, S., Chiu, J. L. Y., Lam, J., Chan, Y., Pavlov, D., Proshin, A. T., Lesch, K., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-021-05982-w · Cited by 146 · see citing works
Brents, L. K., Gallus‐Zawada, A. E., Radominska-p, A., Vasiljevik, T., Prisinzano, T. E., Fantegrossi, W. E., Moran, J. H., & Prather, P. L. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.01.004 · Cited by 143 · see citing works
The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway
Blázquez, C., Chiarlone, A., Bellocchio, L., Resel, E., Pruunsild, P., García-Rincón, D., Sendtner, M., Timmusk, T., Lutz, B., Galve‐Roperh, I., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.11 · Cited by 141 · see citing works
Zhong, P., Wang, W., Pan, B., Liu, X., Zhang, Z., Long, J. Z., Zhang, H., Cravatt, B. F., & Liu, Q.-S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.24 · Cited by 137 · see citing works
Endocannabinoid System Components as Potential Biomarkers in Psychiatry
Navarrete, F., García‐Gutiérrez, M. S., Barba, R. J., Rubio, G., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00315 · Cited by 134 · see citing works
Hill, M. N., Hillard, C. J., & McEwen, B. S. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq280 · Cited by 127 · see citing works
A Guide to Targeting the Endocannabinoid System in Drug Design
Stasiulewicz, A., Znajdek, K., Grudzień, M. K., Pawiński, T., & Sulkowska, J. I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082778 · Cited by 121 · see citing works
Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation
Zoppi, S., Perez‐Nievas, B. G., Madrigal, J. L. M., Manzanares, J., Leza, J. C., & García‐Bueno, B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.214 · Cited by 116 · see citing works
Hill, M. N., & Patel, S. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-19 · Cited by 117 · see citing works
Interleukin-1β Causes Anxiety by Interacting with the Endocannabinoid System
Rossi, S., Sacchetti, L., Napolitano, F., Chiara, V. D., Motta, C., Studer, V., Musella, A., Barbieri, F. R., Bari, M., Bernardi, G., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1515-12.2012 · Cited by 113 · see citing works
Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works
Kunos, G., & Tam, J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01352.x · Cited by 111 · see citing works
The utility of animal models to evaluate novel anti‐obesity agents
Vickers, S. P., Jackson, H. C., & Cheetham, S. C. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01245.x · Cited by 107 · see citing works
Endocannabinoid-mediated synaptic plasticity and addiction-related behavior
Sidhpura, N., & Parsons, L. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.034 · Cited by 92 · see citing works
Su, K., Yu, C. Y., Chen, Y., Huang, Y., Chen, C., Wu, H., & Chen, Y. S. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.8220 · Cited by 90 · see citing works
Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
Roche, M., & Finn, D. P. (2010) · Pharmaceuticals · doi:10.3390/ph3082517 · Cited by 87 · see citing works
Choi, K. H., Le, T., McGuire, J. L., Xing, G., Zhang, L., Li, H., Parker, C. C., Johnson, L. R., & Ursano, R. J. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.03.021 · Cited by 83 · see citing works
Arpana Agrawal, A., Nelson, E. C., Littlefield, A. K., Bucholz, K. K., Degenhardt, L. J., Henders, A. K., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Pergadia, M. L., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2273 · Cited by 83 · see citing works
Cannabinoids and emotionality: a neuroanatomical perspective
McLaughlin, R. J., & Gobbi, G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.052 · Cited by 82 · see citing works
Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression
Gallego‐Landin, I., García-Baos, A., Castro‐Zavala, A., & Valverde, O. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.762738 · Cited by 84 · see citing works
Navarria, A., Tamburella, A., Iannotti, F. A., Micale, V., Camillieri, G., Gozzo, L., Verde, R., Imperatore, R., Leggio, G. M., Drago, F., et al. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.04.014 · Cited by 82 · see citing works
Animal models to improve our understanding and treatment of suicidal behavior
Gould, T. D., Georgiou, P., Brenner, L. A., Brundin, L., Can, A., Courtet, P., Donaldson, Z. R., Dwivedi, Y., Guillaume, S., Gottesman, I. I., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.50 · Cited by 81 · see citing works
Haney, M., Vallée, M., Fabre, S., Collins, S. L., Zanese, M., Campistron, G., Arout, C. A., Foltin, R. W., Cooper, Z. D., Kearney-Ramos, T. E., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02381-w · Cited by 78 · see citing works
Endocannabinoid Signaling in the Etiology and Treatment of Major Depressive Illness
Hillard, C. J., & Liu, Q.-S. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660735 · Cited by 79 · see citing works
Gueye, A. B., Pryslawsky, Y., Trigo, J. M., Poulia, N., Delis, F., Antoniou, K., Loureiro, M., Laviolette, S. R., Vemuri, K., Makriyannis, A., et al. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw068 · Cited by 74 · see citing works
Neumeister, A., Seidel, J., Ragen, B., & Pietrzak, R. H. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.012 · Cited by 76 · see citing works
Bedse, G., Hill, M. N., & Patel, S. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.015 · Cited by 75 · see citing works
Zádor, F., Joca, S. R. L., Nagy-Grócz, G., Dvorácskó, S., Szűcs, E., Tömböly, C., Benyhe, S., & Vécsei, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115903 · Cited by 72 · see citing works
Endocannabinoids and Mental Disorders
Rubino, T., Zamberletti, E., & Parolaro, D. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_9 · Cited by 71 · see citing works
Cascio, M. G., Zamberletti, E., Marini, P., Parolaro, D., & Pertwee, R. G. (2014) · British Journal of Pharmacology · doi:10.1111/bph.13000 · Cited by 67 · see citing works
Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?
Boorman, E., Zajkowska, Z., Ahmed, R., Pariante, C. M., & Zunszain, P. A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4105-9 · Cited by 66 · see citing works
Schurman, L. D., Wills, K. L., Segsworth, B. M., Dashney, B., Rock, E. M., Limebeer, C. L., & Parker, L. A. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.10.008 · Cited by 66 · see citing works
Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD
Ney, L. J., Akhurst, J., Bruno, R., Laing, P. A. F., Matthews, A. J., & Felmingham, K. L. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110118 · Cited by 61 · see citing works
Bambico, F. R., Hattan, P. R., Garant, J.-P., & Gobbi, G. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.006 · Cited by 61 · see citing works
Häring, M., Grieb, M., Monory, K., Lutz, B., & Moreira, F. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.09.002 · Cited by 59 · see citing works
Cannabinoids in depressive disorders
Poleszak, E., Wośko, S., Sławińska, K., Szopa, A., Wróbel, A., & Serefko, A. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.09.058 · Cited by 55 · see citing works
The vital role of constitutive GPCR activity in the mesolimbic dopamine system
Meye, F. J., Ramakers, G. M. J., & Adan, R. A. H. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.130 · Cited by 55 · see citing works
Ward, S. J., & Raffa, R. B. (2011) · Obesity · doi:10.1038/oby.2011.69 · Cited by 50 · see citing works
Burstein, O., Shoshan, N., Doron, R., & Akirav, I. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.026 · Cited by 51 · see citing works
Horder, J., Browning, M., Di Simplicio, M., Cowen, P. J., & Harmer, C. J. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111400649 · Cited by 48 · see citing works
Jenny, M., Schröcksnadel, S., Überall, F., & Fuchs, D. (2010) · Pharmaceuticals · doi:10.3390/ph3082647 · Cited by 69 · see citing works
Gentile, A., Fresegna, D., Musella, A., Sepman, H., Bullitta, S., Vito, F. D., Fantozzi, R., Usiello, A., Maccarrone, M., Mercuri, N. B., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0682-8 · Cited by 48 · see citing works
Wu, Z., Shen, Z., Xu, Y., Chen, S., Xiao, S., Ye, J., Zhang, H., Ma, X., Zhu, Y., Zhu, X., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14520 · Cited by 46 · see citing works
Role of the Endocannabinoid System in Depression: from Preclinical to Clinical Evidence
Micale, V., Tabiová, K., Kučerová, J., & Drago, F. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_5 · Cited by 47 · see citing works
Cannabis controversies: how genetics can inform the study of comorbidity
Arpana Agrawal, A., & Lynskey, M. T. (2014) · Addiction · doi:10.1111/add.12436 · Cited by 45 · see citing works
Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology
Rodrigues, R. S., Lourenço, D. M., Paulo, S. L., Mateus, J. M., Ferreira, M. F., Mouro, F. M., Moreira, J. B., Ribeiro, F. F., Sebastião, A. M., & Xapelli, S. (2019) · Molecules · doi:10.3390/molecules24071350 · Cited by 45 · see citing works
CB1 receptors modulate affective behaviour induced by neuropathic pain
Rácz, I., Nent, E., Erxlebe, E., & Zimmer, A. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.03.005 · Cited by 43 · see citing works
Molecular Alterations of the Endocannabinoid System in Psychiatric Disorders
Navarro, D., Gasparyan, A., Navarrete, F., Torregrosa, A. B., Rubio, G., Marín, M., Acosta, G. B., García‐Gutiérrez, M. S., & Manzanares, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094764 · Cited by 45 · see citing works
Modulation of Endocannabinoid System Components in Depression: Pre-Clinical and Clinical Evidence
Bright, U., & Akirav, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105526 · Cited by 47 · see citing works
Frisardi, V., Panza, F., & Farooqui, A. A. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.04.003 · Cited by 40 · see citing works
The Endocannabinoid/Endovanilloid System and Depression
Smaga, I., Bystrowska, B., Gawliński, D., Przegaliński, E., & Filip, M. (2014) · Current Neuropharmacology · doi:10.2174/1570159x12666140923205412 · Cited by 39 · see citing works
Amchová, P., Kučerová, J., Giugliano, V., Babinská, Z., Zanda, M. T., Scherma, M., Dušek, L., Fadda, P., Micale, V., Šulcová, A., et al. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00044 · Cited by 38 · see citing works
Zádor, F., Kocsis, D., Borsodi, A. D., & Benyhe, S. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2013.12.005 · Cited by 37 · see citing works
Rock, E. M., Sticht, M. A., Duncan, M., Stott, C. G., & Parker, L. A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12322 · Cited by 35 · see citing works
Behavioral assessment of rimonabant under acute and chronic conditions
Ettaro, R., Laudermilk, L. T., Clark, S. D., & Maitra, R. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112697 · Cited by 35 · see citing works
Jiang, H., Ke, B., Liu, J., Ma, G., Hai, K., Gong, D., Yang, Z., & Zhou, C. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000003563 · Cited by 34 · see citing works
NESS06SM reduces body weight with an improved profile relative to SR141716A
Mastinu, A., Pira, M., Pinna, G. A., Pisu, C., Casu, M. A., Reali, R., Marcello, S., Murineddu, G., & Lazzari, P. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.06.001 · Cited by 32 · see citing works
Estrada, J. A., & Contreras, I. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200217140255 · Cited by 32 · see citing works
Gut hormones: the future of obesity treatment?
McGavigan, A. K., & Murphy, K. G. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04278.x · Cited by 31 · see citing works
Circulating endocannabinoids and psychological outcomes in women with PTSD
Botsford, C., Brellenthin, A. G., Cisler, J. M., Hillard, C. J., Koltyn, K. F., & Crombie, K. M. (2022) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2022.102656 · Cited by 29 · see citing works
Bipolar disorder and the endocannabinoid system
Arjmand, S., Behzadi, M., Kohlmeier, K. A., Mazhari, S., Sabahi, A., & Shabani, M. (2019) · Acta Neuropsychiatrica · doi:10.1017/neu.2019.21 · Cited by 29 · see citing works
Cannabinoids and neuroinflammation: Therapeutic implications
Leonard, B. E., & Arıcıoğlu, F. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100463 · Cited by 28 · see citing works
Tejeda-Martínez, A. R., Paredes, J. M. V., Hidalgo-Franco, G. V., Pardo-González, E., Chaparro-Huerta, V., González-Castañeda, R., & Flores-Soto, M. E. (2021) · Behavioural Neurology · doi:10.1155/2021/6651492 · Cited by 28 · see citing works
Kaminitz, A., Barzilay, R., Segal‐Gavish, H., Taler, M., Offen, D., Gil‐Ad, I., Mechoulam, R., & Weizman, A. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.841993 · Cited by 27 · see citing works
de la Tremblaye, P. B., O’Neil, D. A., LaPorte, M. J., B, J. P. C. A., Beitchman, J. A., Thomas, T. C., Bondi, C. O., & Kline, A. E. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.022 · Cited by 25 · see citing works
Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression
Li, S., Luo, H., Lou, R., Tian, C., Chen, M., Xia, L., Pan, C., Duan, X., Dang, T., Li, H. Z., et al. (2021) · Science Advances · doi:10.1126/sciadv.abf0634 · Cited by 25 · see citing works
Janero, D. R., Lindsley, L., Vemuri, K. V., & Makriyannis, A. (2011) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2011.608063 · Cited by 25 · see citing works
Brain endocannabinoid signaling exhibits remarkable complexity
Gorzkiewicz, A., & Szemraj, J. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.06.012 · Cited by 24 · see citing works
Choi, J.-E., Borkowski, K., Newman, J. W. I., & Park, Y. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108599 · Cited by 23 · see citing works
Zádor, F., Lénárt, N., Csibrány, B., Sántha, M., Molnar, M. F., Tuka, B., Samavati, R., Klivènyi, P., Vécsei, L., Marton, A., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.008 · Cited by 21 · see citing works
Simone, J. J., Baumbach, J. L., & McCormick, C. M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.10.029 · Cited by 21 · see citing works
How do stupendous cannabinoids modulate memory processing via affecting neurotransmitter systems?
Vaseghi, S., Nasehi, M., & Zarrindast, M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.018 · Cited by 21 · see citing works
Foll, B. L., Pushparaj, A. P., Pryslawsky, Y., Forget, B., Vemuri, K. V., Makriyannis, A., & Trigo, J. M. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.009 · Cited by 20 · see citing works
Soriano, D., Brusco, A., & Caltana, L. R. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113007 · Cited by 18 · see citing works
Zádor, F., Ötvös, F., Benyhe, S., Zimmer, A., & Páldy, E. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.05.015 · Cited by 20 · see citing works
Unexpected short- and long-term effects of chronic adolescent HU-210 exposure on emotional behavior
Farinha‐Ferreira, M., Rei, N., Fonseca‐Gomes, J., Miranda‐Lourenço, C., Serrão, P., Vaz, S. H., Gomes, J. I., Martins, V., Pereira, B. D. A., & Sebastião, A. M. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109155 · Cited by 19 · see citing works
Coelho, A. A., Bastos, S., Gobira, P. H., & Lisboa, S. F. D. S. (2023) · Neuronal Signaling · doi:10.1042/ns20220034 · Cited by 22 · see citing works
Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety.
Yang, W., Gong, X.-B., Sun, H.-G., Wu, C., Suo, J., Ji, J., Jiang, X.-R., Shen, J., He, Y., & Aisa, H. (2023) · European journal of medicinal chemistry · doi:10.1016/j.ejmech.2023.116048 · Cited by 17 · see citing works
The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review
Davis, M. P., Behm, B., Mehta, Z. Y., & Fernandez, C. (2019) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909119850807 · Cited by 19 · see citing works
URB597 ameliorates the deleterious effects induced by binge alcohol consumption in adolescent rats
Bellozi, P. M. Q., Pelição, R., dos Santos, M. C., Lima, I. V. D. A., Saliba, S. W., Vieira, É. L. M., Campos, A. C., Teixeira, A. L., de Oliveira, A. C. P., Nakamura-Palacios, E. M., et al. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134408 · Cited by 18 · see citing works
The Endocannabinoid System as Modulator of Exercise Benefits in Mental Health
Amatriain‐Fernández, S., Budde, H., Gronwald, T., Quiroga, C., Carreón, C., Viana-Torre, G., Yamamoto, T., Imperatori, C., Machado, S. E. D. C., & Murillo‐Rodríguez, E. (2020) · Current Neuropharmacology · doi:10.2174/1570159x19666201218112748 · Cited by 17 · see citing works
Sbarski, B., & Akirav, I. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.05.008 · Cited by 17 · see citing works
Crouzin, N., Ferreira, M. D. J., Cohen‐Solal, C., M’Kadmi, C., Bernad, N., Martínez, J., Barbanel, G., Vignes, M., & Guiramand, J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.07.012 · Cited by 17 · see citing works
Murkar, A., Kendzerska, T., Shlik, J., Quilty, L. C., Saad, M., & Robillard, R. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04185-7 · Cited by 17 · see citing works
Metabolic Profiling of CB1 Neutral Antagonists
Seltzman, H. H., Maitra, R., Bortoff, K., Henson, J., Reggio, P. H., Wesley, D., & Tam, J. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.06.025 · Cited by 16 · see citing works
Hjorth, S., Karlsson, C., Jučaitė, A., Varnäs, K., Hamrén, U. W., Johnström, P., Gulyás, B. Z., Donohue, S. R., Pike, V. W., Halldin, C., et al. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.03.002 · Cited by 16 · see citing works
Endocannabinoids and Stress Resilience: Is Deficiency Sufficient to Promote Vulnerability?
Hill, M. N., & Lee, F. S. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.03.2099 · Cited by 15 · see citing works
Soler‐Cedeño, O., Alton, H., Bi, G., Linz, E., Ji, L., Makriyannis, A., & Xi, Z. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01861-y · Cited by 15 · see citing works
Poleszak, E., Wośko, S., Sławińska, K., Wyska, E., Szopa, A., Świąder, K., Wróbel, A., Doboszewska, U., Właź, P., Właź, A., et al. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172833 · Cited by 14 · see citing works
Chang, J. P., Iqbal, A. Z., Do, Q. L., Yaseen, M., Wu, S., Malau, I. A., Zailani, H., & Su, K. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107857 · Cited by 13 · see citing works
McLaughlin, P. J., Jagielo-Miller, J. E., Plyler, E. S., Schutte, K., Vemuri, K. V., & Makriyannis, A. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4548-2 · Cited by 13 · see citing works
Keimpema, E., Hökfelt, T. G. M., Harkany, T., & Doherty, P. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12431 · Cited by 13 · see citing works
Patel, K. N., Joharapurkar, A. A., PATEL, V. G., Kshirsagar, S. G., Bahekar, R. H., Srivastava, B. K., & Jain, M. R. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0310 · Cited by 13 · see citing works
- Authors
- Beyer, C. E., Dwyer, J. M., Piesla, M. J., Platt, B. J., Shen, R., Rahman, Z., Chan, K., Manners, M. T., Samad, T. A., Kennedy, J. D., Bingham, B., & Whiteside, G. T.
- Affiliations
- Pfizer (United States) (US)
- Corresponding author
- Beyer, Chad E.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 39
- Issue
- 2
- Pages
- 148-155
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W1970437559
- Cited by
- 160
- References
- 44
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 12 · 2020: 13 · 2019: 10 · 2018: 5 · 2017: 11 · 2016: 6 · 2015: 7 · 2014: 18 · 2013: 9 · 2012: 13
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- rimonabant, CB1 receptor antagonism, depression-like behavior, anhedonia, forced swim test, sucrose intake, chronic mild stress, serotonin, hippocampal neurogenesis, brain-derived neurotrophic factor, inflammatory cytokines, interferon-gamma, TNF-α, mood disorders
- MeSH terms
- Rimonabant, Analysis of Variance, Animals, Cell Survival, Disease Models, Animal, Flow Cytometry, Food Preferences, Frontal Lobe, Male, Phenotype, Piperidines, Pyrazoles, Stress, Psychological, Sucrose, Sweetening Agents, Swimming, Cytokines, Rats, Sprague-Dawley, Microdialysis, Brain-Derived Neurotrophic Factor, Receptor, Cannabinoid, CB1, Immobility Response, Tonic, Cell Proliferation, Rats
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