The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet
Open accessAbstract
The mechanisms underlying the efficacy of the ketogenic diet (KD) remain unknown. Recently, we showed that the KD increased glutathione (GSH) biosynthesis. Since the NF E2-related factor 2 (Nrf2) transcription factor is a primary responder to cellular stress and can upregulate GSH biosynthesis, we asked whether the KD activates the Nrf2 pathway. Here we report that rats consuming a KD show acute production of H2O2 from hippocampal mitochondria, which decreases below control levels by 3 weeks, suggestive of an adaptive response. 4-hydroxy-2-nonenal (4-HNE), an electrophilic lipid peroxidation end product known to activate the Nrf2 detoxification pathway was also acutely increased by the KD. Nrf2 nuclear accumulation was evident in both the hippocampus and liver, and the Nrf2 target, NAD(P)H:quinone oxidoreductase (NQO1), exhibited increased activity in both the hippocampus and liver after 3 weeks. We also found chronic depletion of liver tissue GSH, while liver mitochondrial antioxidant capacity was preserved. These data suggest that the KD initially produces mild oxidative and electrophilic stress which may systemically activate the Nrf2 pathway via redox signaling leading to chronic cellular adaptation, induction of protective proteins, and improvement of the mitochondrial redox state.
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Ketone bodies: from enemy to friend and guardian angel
Kolb, H., Kempf, K., Röhling, M., Lenzen-Schulte, M., Schloot, N. C., & Martin, S. (2021) · BMC Medicine · doi:10.1186/s12916-021-02185-0 · Cited by 361
Ketogenic Diet in Alzheimer’s Disease
Rusek, M., Pluta, R., Ułamek-Kozioł, M., & Czuczwar, S. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163892 · Cited by 319
Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial
Phillips, M. C. L., Murtagh, D. K. J., Gilbertson, L. J., Asztely, F. J. S., & Lynch, C. D. P. (2018) · Movement Disorders · doi:10.1002/mds.27390 · Cited by 292
Mitochondrial dysfunction and oxidative stress: A contributing link to acquired epilepsy?
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Metadata
- Authors
- Milder, J. B., Liang, L.-P., & Patel, M.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 40
- Issue
- 1
- Pages
- 238-244
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W1976266172
- Cited by
- 212
- References
- 5
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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