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Cited by 264Epilepsy research and treatmentMitochondrial Function and PathologyDiet and metabolism studies

Mitochondrial dysfunction and oxidative stress: A contributing link to acquired epilepsy?

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Waldbaum, Simon, Patel, Manisha·2010·Journal of Bioenergetics and Biomembranes
DOI 10.1007/s10863-010-9320-9PMC PMC3102435
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Abstract

Mitochondrial dysfunction and oxidative stress contribute to several neurologic disorders and have recently been implicated in acquired epilepsies such as temporal lobe epilepsy (TLE). Acquired epilepsy is typically initiated by a brain injury followed by a "latent period" whereby molecular, biochemical and other cellular alterations occur in the brain leading to chronic epilepsy. Mitochondrial dysfunction and oxidative stress are emerging as factors that not only occur acutely as a result of precipitating injuries such as status epilepticus (SE), but may also contribute to epileptogenesis and chronic epilepsy. Mitochondria are the primary site of reactive oxygen species (ROS) making them uniquely vulnerable to oxidative damage that may affect neuronal excitability and seizure susceptibility. This mini-review provides an overview of evidence suggesting the role of mitochondrial dysfunction and oxidative stress as acute consequences of injuries that are known to incite chronic epilepsy and their involvement in the chronic stages of acquired epilepsy.

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  • Oxidative DNA damage and mitochondrial dysfunction are thought to contribute to neurodegeneration of AD, vascular dementia, HD, PD and epilepsy.

    “Oxidative DNA damage and mitochondrial dysfunction are thought to contribute to the neurodegeneration of AD [75,76], vascular dementia [77], HD [78], PD [79] and epilepsy [80].”

    From Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer’s Disease? (2022) · cites this paper as [80]

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Authors
Waldbaum, S., & Patel, M.
Affiliations
University of Colorado Anschutz (US)
Corresponding author
Patel, Manisha
ORCID
Patel, Manisha
Venue
Journal of Bioenergetics and Biomembranes
Publisher
Springer Science and Business Media LLC
Published
2010-12
Volume
42
Issue
6
Pages
449-455
ISSN
  • 0145-479X (ISSN-L)
  • 1573-6881
DOI
10.1007/s10863-010-9320-9
PMC
PMC3102435
OpenAlex
W1969430202
Cited by
264
References
0
Citations by year
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FWCI
1.85
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Bioenergetics and Biomembranes (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS039587)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
Keywords
mitochondrial dysfunction, oxidative stress, acquired epilepsy, temporal lobe epilepsy, epileptogenesis, status epilepticus, reactive oxygen species, chronic epilepsy, brain injury, neuronal excitability, seizure susceptibility
MeSH terms
Energy Metabolism, Epilepsy, Temporal Lobe, Humans, Mitochondria, Neurons, Oxidation-Reduction, Reactive Oxygen Species, Oxidative Stress

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