The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Long non-coding RNA expression profiles predict clinical phenotypes in glioma
Open accessAbstract
Glioma is the commonest form of primary brain tumor in adults with varying malignancy grades and histological subtypes. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been shown to play important roles in cancer development. To discover novel tumor-related lncRNAs and determine their associations with glioma subtypes, we first applied a lncRNA classification pipeline to identify 1970 lncRNAs that were represented on Affymetrix HG-U133 Plus 2.0 array. We then analyzed the lncRNA expression patterns in a set of previously published glioma gene expression profiles of 268 clinical specimens, and identified sets of lncRNAs that were unique to different histological subtypes (astrocytic versus oligodendroglial tumors) and malignancy grades. These lncRNAs signatures were then subject to validation in another non-overlapping, independent data set that contained 157 glioma samples. This is the first reported study that correlates lncRNA expression profiles with malignancy grade and histological differentiation in human gliomas. Our findings indicate the potential roles of lncRNAs in the biogenesis, development and differentiation of gliomas, and provide an important platform for future studies.
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Cites
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Self-citationLong non-coding RNAs: insights into functions
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
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“…that lncRNAs are associated with a diverse range of functions in cell biology (Kaikkonen et al., 2011; Khalil et al., 2009; Mercer et al., 2009; Tsai et al., 2010), and the aberrant expressions of lncRNAs have been linked with cancer (Hibi et al., 1996; Huang et al., 2002; Ji et al., 2003;…”
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Specific expression of long noncoding RNAs in the mouse brain
Mercer, T. R., Dinger, M. E., Sunkin, S. M., Mehler, M. F., & Mattick, J. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706729105 · Cited by 1,103
Cited by
Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis
Ye, W.-C., Huang, S.-F., Hou, L.-J., Long, H.-J., Yin, K., Hu, C. Y., & Zhao, G.-J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.688546 · Cited by 19
Metadata
- Authors
- Zhang, X., Sun, S., Pu, J. K. S., Tsang, A. C. O., Lee, D., Man, V. O. Y., Lui, W. M., Wong, S. T. S., & Leung, G. K. K.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 48
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W1997602512
- Cited by
- 341
- References
- 12
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, X., Sun, S., Pu, J. K. S., Tsang, A. C. O., Lee, D., Man, V. O. Y., Lui, W. M., Wong, S. T. S., & Leung, G. K. K. (2012). Long non-coding RNA expression profiles predict clinical phenotypes in glioma. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2012.06.004
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