Rapidly progressive dementia
Open accessAbstract
Rapidly progressive dementias (RPDs) are neurologic conditions that develop subacutely over weeks to months or, rarely, acutely over days. In contrast to most dementing conditions that take years to progress to death, RPD quickly can be fatal. It is critical to evaluate patients who have RPD without delay, usually in a hospital setting, as they may have a treatable condition. This review discusses a differential diagnostic approach to RPD, emphasizing neurodegenerative, toxic and metabolic, infectious, autoimmune, neoplastic, and other conditions to consider.
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Sporadic (idiopathic) Alzheimer's disease is slowly progressive and is the most common cause of dementia in those aged 65 and older, making up more than 90% of disease cases.
“Sporadic (idiopathic) AD is slowly progressive and the most common cause of dementia in those aged 65 and older making more than 90% of the disease cases (Geschwind et al., 2007).”
From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Geschwind et al., 2007
The Introduction says that most slowly progressive dementias are due to Alzheimer's disease, and its discussion of chronic degenerative dementias says AD is rarely rapid. It does not specify sporadic or idiopathic AD, establish the claim for people aged 65 and older, or give a figure exceeding 90% of cases. (LLM, conf=0.88)
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Prion disorders and other rapidly progressive dementias
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- Authors
- Geschwind, M. D., Haman, A., & Miller, B. L.
- Affiliations
- University of California San Francisco Medical Center (US)
- Corresponding author
- Geschwind, Michael D.
- Venue
- Neurologic Clinics
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 25
- Issue
- 3
- Pages
- 783-807
- ISSN
- 0733-8619 (ISSN-L)
- PMC
- PMC2706263
- OpenAlex
- W2115178591
- Cited by
- 143
- References
- 220
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 10 · 2018: 13 · 2017: 10 · 2016: 12 · 2015: 3 · 2014: 7 · 2013: 7 · 2012: 11
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurologic Clinics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG031189)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Surgery › Medical Case Reports and Studies
- Keywords
- rapidly progressive dementia, differential diagnosis, neurodegenerative dementia, autoimmune encephalopathy, treatable dementia
- MeSH terms
- Algorithms, Brain Diseases, Diagnosis, Differential, Humans, Creutzfeldt-Jakob Syndrome, Practice Guidelines as Topic
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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