The DOI matches its Crossref record; 169 of the 170 references it cites were found in a registry or an index.
A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition
Abstract
Influences of the habenular complex on electrophysiological and neurochemical aspects of brain functioning are well known. However, its role in cognition has been sparsely investigated until recently. The habenular complex, composed of medial and lateral subdivisions, is a node linking the forebrain with midbrain and hindbrain structures. The lateral habenula is the principal actor in this direct dialogue, while the medial habenula mostly conveys information to the interpeduncular nucleus before this modulates further regions. Here we describe neuroanatomical and physiological aspects of the habenular complex, and its role in cognitive processes, including new behavioral, electrophysiological and imaging findings. Habenular complex lesions result in deficits in learning, memory and attention, some of which decline during repeated testing, while others become worse, consistent with multiple roles in cognition. The habenular complex is particularly responsive to feedback about errors. Electrophysiological studies indicate a role in metaplasticity, the modulation of neuroplasticity. These studies thus reveal important roles of the habenular complex in learning, memory and attention.
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“Unlike LHb, the MHb projects almost exclusively to the interpeduncular nucleus (IPN) via the fasciculus retroflexus (Fr) (Lecourtier and Kelly 2007;Hikosaka 2010).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Lecourtier and Kelly 2007
In the citing paper
“In particular, the LHb projects densely to the rostromedial tegmental nucleus (RMTg) (Jhou et al. 2009), and has a well-established inhibitory effect on the firing of midbrain DA neurons (Lecourtier and Kelly 2007;Matsumoto and Hikosaka 2009;Hikosaka 2010;Bromberg-Martin and Hikosaka 2011).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Lecourtier and Kelly 2007
In the citing paper
“The habenula is a diencephalic structure located on the dorsomedial surface of the caudal thalamus that is segregated into medial (MHb) and lateral (LHb) domains (Lecourtier and Kelly 2007;Hikosaka 2010).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Lecourtier and Kelly 2007
In the citing paper
“LHb neurons are excited by omission of anticipated rewards or exposure to aversive stimuli (Lecourtier and Kelly 2007;Matsumoto and Hikosaka 2009;Hikosaka 2010;Bromberg-Martin and Hikosaka 2011).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Lecourtier and Kelly 2007
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The habenula: from stress evasion to value-based decision-making
Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955
Neurophysiology of performance monitoring and adaptive behavior
Ullsperger, M., Danielmeier, C., & Jocham, G. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2012 · Cited by 634
Synaptic potentiation onto habenula neurons in the learned helplessness model of depression
Li, B., Piriz, J., Mirrione, M., Chung, C., Proulx, C. D., Schulz, D., Henn, F., & Malinow, R. (2011) · Nature · doi:10.1038/nature09742 · Cited by 634
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Metadata
- Authors
- Lecourtier, L., & Kelly, P. H.
- Affiliations
- University of Pittsburgh (US)
- Novartis (Switzerland) (CH)
- Corresponding author
- Lecourtier, Lucas
- ORCID
- Lecourtier, Lucas
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 31
- Issue
- 5
- Pages
- 658-672
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W1969480244
- Cited by
- 283
- References
- 170
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 10 · 2023: 4 · 2022: 10 · 2021: 15 · 2020: 9 · 2019: 12 · 2018: 15 · 2017: 25 · 2016: 19 · 2015: 13 · 2014: 30 · 2013: 28 · 2012: 11
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- lateral habenula, medial habenula, interpeduncular nucleus, cognition, learning and memory, attention, metaplasticity, neuroplasticity, error feedback, neuroanatomy
- MeSH terms
- Animals, Cognition, Humans, Synaptic Transmission, Biogenic Monoamines, Habenula
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