The DOI matches its Crossref record; 214 of the 214 references it cites were found in a registry or an index.
Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors
Abstract
There is now strong evidence of progressive neuropathological processes in bipolar disorder (BD). On this basis, the current understanding of the neurobiology of BD has shifted from an initial focus on monoamines, subsequently including evidence of changes in intracellular second messenger systems and more recently to, incorporating changes in inflammatory cytokines, corticosteroids, neurotrophins, mitochondrial energy generation, oxidative stress and neurogenesis into a more comprehensive model capable of explaining some of the clinical features of BD. These features include progressive shortening of the inter-episode interval with each recurrence, occurring in consort with reduced probability of treatment response as the illness progresses. To this end, emerging data shows that these biomarkers may differ between early and late stages of BD in parallel with stage-related structural and neurocognitive alterations. This understanding facilitates identification of rational therapeutic targets, and the development of novel treatment classes. Additionally, these pathways provide a cogent explanation for the efficacy of seemingly diverse therapies used in BD, that appear to share common effects on oxidative, inflammatory and neurotrophic pathways.
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In the citing paper
“bipolar disorder (BD) [10–14]”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [14]
In the citing paper
“There is strong evidence that inflammation and oxidative stress underlie the progression of depression, anxiety and bipolar disorder (Berk et al., 2011; Milaneschi et al., 2021).”
From An application of the stress-diathesis model: A review about the association between smoking tobacco, smoking cessation, and mental health (2023) · cites this paper as Berk et al., 2011
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Cites
Items 201–214 of 214
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Self-citationAtypical mood stabilizers: a ‘typical’ role for atypical antipsychotics
Malhi, G. S., Berk, M., Bourin, M., Ivanovski, B., Dodd, S., Lagopoulos, J., & Mitchell, P. B. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00524.x · Cited by 32
Self-citationPredictors of antidepressant response: A selective review
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Self-citationTreatment of bipolar mania with atypical antipsychotics
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Self-citationOxidative stress may be a common mechanism linking major depression and osteoporosis
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Cited by
Sorted by citations
Grande, I., Berk, M., Birmaher, B., & Vieta, E. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00241-x · Cited by 1,710
Self-citationMcIntyre, R. S., Berk, M., Brietzke, E., Goldstein, B. I., López-Jaramillo, C., Kessing, L. V., Malhi, G. S., Nierenberg, A. A., Rosenblat, J. D., Majeed, A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31544-0 · Cited by 1,047
Self-citationVieta, E., Berk, M., Schulze, T. G., Carvalho, A. F., Suppes, T., Calabrese, J. R., Gao, K., Miskowiak, K. W., & Grande, I. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.8 · Cited by 891
Self-citationLeonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.005 · Cited by 805
Self-citationBrain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750
Metadata
- Authors
- Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., Magalhães, P. V. S., Amminger, P., McGorry, P., & Malhi, G. S.
- Affiliations
- Barwon Health (AU)
- Universidade Federal do Rio Grande do Sul (BR)
- Mental Health Research Institute (AU)
- Piyavate Hospital (TH)
- The University of Melbourne (AU)
- The University of Sydney (AU)
- Corresponding author
- Berk, M.
- ORCID
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 35
- Issue
- 3
- Pages
- 804-817
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2142476463
- Cited by
- 1,178
- References
- 214
- Citations by year
- 2026: 49 · 2025: 50 · 2024: 50 · 2023: 54 · 2022: 56 · 2021: 70 · 2020: 95 · 2019: 82 · 2018: 89 · 2017: 90 · 2016: 103 · 2015: 110 · 2014: 89 · 2013: 92 · 2012: 69
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, neuroprogression, neuroinflammation, oxidative stress, neurotrophic factors, neurotrophins, inflammatory cytokines, corticosteroids, mitochondrial bioenergetics, neurogenesis, treatment response, biomarkers, brain structural changes, neurocognitive impairment, therapeutic target
- MeSH terms
- Animals, Bipolar Disorder, Humans, Inflammation, Nerve Growth Factors, Cytokines, Neurotransmitter Agents, Oxidative Stress, Disease Progression, Neuroprotective Agents
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