Maes, Michael

Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies

Köhler, C. A., Freitas, T. H., Maes, M., de Andrade, N. Q., Liu, C. S., Fernandes, B. S., Stubbs, B., Solmi, M., Veronese, N., Herrmann, N., et al. (2017) · Acta Psychiatrica Scandinavica

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 1,443

So depression is an inflammatory disease, but where does the inflammation come from?

Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., et al. (2013) · BMC Medicine

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 1,423

Cytokines and major depression

Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 1,235

Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors

Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews

Bipolar Disorder and TreatmentTreatment of Major Depression

Cited by 1,178

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry

Antioxidant Activity and Oxidative StressTryptophan and brain disorders

Cited by 1,140

Evidence for an immune response in major depression: A review and hypothesis

Maes, M. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 1,003

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease

Tryptophan and brain disordersTreatment of Major Depression

Cited by 894

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

Leonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews

Tryptophan and brain disordersTreatment of Major Depression

Cited by 805

THE EFFECTS OF PSYCHOLOGICAL STRESS ON HUMANS: INCREASED PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND Th1-LIKE RESPONSE IN STRESS-INDUCED ANXIETY

Maes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., Bosmans, E., De Meester, I., Benoy, I., Neels, H., et al. (1998) · Cytokine

Stress Responses and CortisolTryptophan and brain disorders

Cited by 772

INCREASED SERUM IL-6 AND IL-1 RECEPTOR ANTAGONIST CONCENTRATIONS IN MAJOR DEPRESSION AND TREATMENT RESISTANT DEPRESSION

Maes, M., Bosmans, E., De Jongh, R., Kenis, G., Vandoolaeghe, E., & Neels, H. (1997) · Cytokine

Tryptophan and brain disordersTreatment of Major Depression

Cited by 728

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

Maes, M., Leonard, B. E., Myint, A. M., Kubera, M., & Verkerk, R. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry

Tryptophan and brain disordersTreatment of Major Depression

Cited by 700

Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways

Maes, M., Berk, M., Goehler, L., Song, C., Anderson, G., Gałecki, P., & Leonard, B. (2012) · BMC Medicine

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 629

Increased Plasma Concentrations of Interleukin-6, Soluble Interleukin-6, Soluble Interleukin-2 and Transferrin Receptor in Major Depression

Maes, M., Meltzer, H. Y., Bosmans, E., Bergmans, R., Vandoolaeghe, E., Ranjan, R., & Desnyder, R. (1995) · Journal of Affective Disorders

Tryptophan and brain disordersTreatment of Major Depression

Cited by 622

Major Depression and Activation of The Inflammatory Response System

Maes, M. (1999) · Advances in Experimental Medicine and Biology

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 617

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 544

The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications

Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry

Treatment of Major DepressionTryptophan and brain disorders

Cited by 529

Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy

Capuron, L., Ravaud, A., Neveu, P. J., Miller, A. H., Maes, M., & Dantzer, R. (2002) · Molecular Psychiatry

Tryptophan and brain disordersTreatment of Major Depression

Cited by 473

Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: Possible treatments targeting the TLR4 pathway

Lucas, K., & Maes, M. (2013) · Molecular Neurobiology

Immune Response and InflammationInflammasome and immune disorders

Cited by 466

Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder: systematic review and meta-analysis

Köhler, C. A., Freitas, T. H., Stubbs, B., Maes, M., Solmi, M., Veronese, N., de Andrade, N. Q., Morris, G., Fernandes, B. S., Brunoni, A. R., et al. (2017) · Molecular Neurobiology

Tryptophan and brain disordersTreatment of Major Depression

Cited by 449

Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut

Maes, M., Kubera, M., Leunis, J.-C., & Berk, M. (2012) · Journal of Affective Disorders

Tryptophan and brain disordersGut microbiota and health

Cited by 446

IDO and interferon-α-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity

Wichers, M. C., Koek, G. H., Robaeys, G., Verkerk, R., Scharpé, S., & Maes, M. (2005) · Molecular Psychiatry

Tryptophan and brain disordersTreatment of Major Depression

Cited by 445

In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression

Kubera, M., Obuchowicz, E., Goehler, L., Brzeszcz, J., & Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 443

Increased Depressive Ratings in Patients With Hepatitis C Receiving Interferon-α–Based Immunotherapy Are Related to Interferon-α–Induced Changes in the Serotonergic System

Bonaccorso, S., Marino, V., Puzella, A., Pasquini, M., Biondi, M., Artini, M., Almerighi, C., Verkerk, R., Meltzer, H., & Maes, M. (2002) · Journal of Clinical Psychopharmacology

Tryptophan and brain disordersTreatment of Major Depression

Cited by 437

Fatty acid composition in major depression: decreased ω3 fractions in cholesteryl esters and increased C20:4ω6C20:5ω3 ratio in cholesteryl esters and phospholipids

Maes, M., Smith, R., Christophe, A., Cosyns, P., Desnyder, R., & Meltzer, H. (1996) · Journal of Affective Disorders

Fatty Acid Research and HealthTryptophan and brain disorders

Cited by 417