Cited by 359Pain Mechanisms and TreatmentsPain Management and TreatmentMusculoskeletal pain and rehabilitation

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Psychological processing in chronic pain: A neural systems approach

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Simons, Laura E., Elman, Igor, Borsook, David·2014·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2013.12.006PMC PMC3944001

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Abstract

Our understanding of chronic pain involves complex brain circuits that include sensory, emotional, cognitive and interoceptive processing. The feed-forward interactions between physical (e.g., trauma) and emotional pain and the consequences of altered psychological status on the expression of pain have made the evaluation and treatment of chronic pain a challenge in the clinic. By understanding the neural circuits involved in psychological processes, a mechanistic approach to the implementation of psychology-based treatments may be better understood. In this review we evaluate some of the principle processes that may be altered as a consequence of chronic pain in the context of localized and integrated neural networks. These changes are ongoing, vary in their magnitude, and their hierarchical manifestations, and may be temporally and sequentially altered by treatments, and all contribute to an overall pain phenotype. Furthermore, we link altered psychological processes to specific evidence-based treatments to put forth a model of pain neuroscience psychology.

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Authors: Simons, L. E., Elman, I., & Borsook, D.
Affiliations: Boston Children's Hospital (US)
Veterans Administration (US)
Corresponding author: Simons, Laura E.
ORCID: Simons, Laura E.
Elman, Igor
Borsook, David
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2014-02
Volume: 39
Pages: 61-78
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2013.12.006
PMC: PMC3944001
OpenAlex: W2065687898
Cited by: 359
References: 273
Citations by year: 2026: 16 · 2025: 27 · 2024: 26 · 2023: 27 · 2022: 26 · 2021: 32 · 2020: 39 · 2019: 45 · 2018: 29 · 2017: 36 · 2016: 23 · 2015: 19 · 2014: 14
FWCI: 3.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (K24NS064050, NS064050)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD067202, HD067202)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords: chronic pain, pain neuroscience education, neural circuits, emotional pain, interoception, cognitive processes, pain phenotypes, psychological treatment of pain, pain expression
MeSH terms: Brain, Female, Humans, Male, Nerve Net, Sex Factors, Chronic Pain

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Psychological processing in chronic pain: A neural systems approach

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