Depression and Pain Comorbidity: A Literature Review

Bair, Matthew J.; Robinson, Rebecca L.; Katon, Wayne; Kroenke, Kurt

doi:10.1001/archinte.163.20.2433

Cited by 3,463Musculoskeletal pain and rehabilitationPsychosomatic Disorders and Their TreatmentsTreatment of Major Depression

Depression and Pain Comorbidity: A Literature Review

Open access

Bair, Matthew J., Robinson, Rebecca L., Katon, Wayne, Kroenke, Kurt·2003·Archives of Internal Medicine

DOI 10.1001/archinte.163.20.2433

Open this paper in CoChat — free account Open PDF

Abstract

Because depression and painful symptoms commonly occur together, we conducted a literature review to determine the prevalence of both conditions and the effects of comorbidity on diagnosis, clinical outcomes, and treatment. The prevalences of pain in depressed cohorts and depression in pain cohorts are higher than when these conditions are individually examined. The presence of pain negatively affects the recognition and treatment of depression. When pain is moderate to severe, impairs function, and/or is refractory to treatment, it is associated with more depressive symptoms and worse depression outcomes (eg, lower quality of life, decreased work function, and increased health care utilization). Similarly, depression in patients with pain is associated with more pain complaints and greater impairment. Depression and pain share biological pathways and neurotransmitters, which has implications for the treatment of both concurrently. A model that incorporates assessment and treatment of depression and pain simultaneously is necessary for improved outcomes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/archinte.163.20.2433

Cites

178 of 178 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Chronic pain commonly coexists with depression and anxiety, and these conditions are bidirectional risk factors for one another.
“Chronic pain commonly coexists with depression and anxiety, and these conditions are bidirectional risk factors for one another [1-5].”
From Behavioral Mechanisms That Mediate Mental and Physical Health Improvements in People With Chronic Pain Who Receive a Digital Health Intervention: Prospective Cohort Pilot Study (2023) · cites this paper as [1]
The Abstract and Conclusions describe pain and depression as frequent comorbidities with a reciprocal relationship; the Conclusions also say depression predicts future episodes of pain. The paper does not establish the same co-occurrence or bidirectional risk relationship for anxiety, so that part of the claim is unsupported. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Chronic pain is often associated with psychological distress, which complicates adjustment to chronic pain.
“Chronic pain is often associated with psychological distress, which complicates adjustment to chronic pain [3, 4],”
From A 13-weeks mindfulness based pain management program improves psychological distress in patients with chronic pain compared with waiting list controls (2016) · cites this paper as [3]
Chronic pain is highly comorbid with depression.
“chronic pain has also been found to be highly comorbid with depression”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Bair, Robinson, Katon, & Kroenke, 2003
There are high rates of unemployment and impairments in social functioning among patients with depression and pain.
“There are high rates of unemployment and impairments in social functioning among patients with depression and pain (Bair et al., 2003).”
From Presence and predictors of pain in depression: Results from the FINDER study (2010) · cites this paper as Bair et al., 2003
Depression is known to be associated with pain and pain-related outcomes.
“depression is known to be associated with pain and pain-related outcomes,4”
From Telehealth Versus In-Person Acceptance and Commitment Therapy for Chronic Pain: A Randomized Noninferiority Trial. (2017) · cites this paper as Bair et al., 2003

Analyses to address hypotheses 1 and 2 were adjusted for baseline PHQ-9 scores, except when PHQ-9 was the outcome.
“Analyses to address hypotheses 1 and 2 were adjusted for baseline PHQ-9 scores (except when PHQ-9 was the outcome) because depression is known to be associated with pain and pain-related outcomes,4”
From Telehealth Versus In-Person Acceptance and Commitment Therapy for Chronic Pain: A Randomized Noninferiority Trial. (2017) · cites this paper as Bair et al., 2003
Developing an enduring pain condition substantially increases vulnerability for a later diagnosis of an affective disorder.
“the development of an enduring pain condition confers a substantially increased vulnerability for the subsequent diagnosis of an affective disorder”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [16]
Longitudinal observational research supports a strong bidirectional link between mood disorders and persistent pain.
“longitudinal, observational research supports a strong bidirectional link between mood disorders and persistent pain”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [16]
Depression, anxiety, and distress are among the strongest and most robust psychosocial predictors of transition from acute to chronic pain.
“psychosocial variables such as depression, anxiety, and distress are among the most potent and robust predictors of the transition from acute to chronic pain 13–18.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [16]
On average, 52% of patients with pain meet criteria for depression.
“an average of 52% of patients with pain fulfill the criteria for depression.27”
From Impact of psychological factors in the experience of pain (2011) · cites this paper as [27]
Depression in a pain condition is associated with greater pain intensity and is a strong risk factor for disability.
“The presence of depression in a pain condition is associated with higher levels of pain intensity and is a potent risk factor for disability.27,29”
From Impact of psychological factors in the experience of pain (2011) · cites this paper as [27]
Up to half of over 70 million Americans with chronic musculoskeletal pain have a comorbid diagnosis of depression and/or anxiety.
“Of the over 70 million Americans who have chronic musculoskeletal pain, up to half of them have a comorbid diagnosis of depression and/or anxiety [1-4].”
From A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study (2022) · cites this paper as [2]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007 · see citing works
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629 · see citing works
National Institute of Mental Health Treatment of Depression Collaborative Research Program: General Effectiveness of Treatments
Elkin, I. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110013002 · Cited by 2,300 · see citing works
A review of psychological risk factors in back and neck pain
Linton, S. J. (2000) · Spine · doi:10.1097/00007632-200005010-00017 · Cited by 1,776 · see citing works
Persistent Pain and Well-being: A World Health Organization Study in Primary Care
Gureje, O., Von Korff, M., Simon, G. E., & Gater, R. (1998) · JAMA · doi:10.1001/jama.280.2.147 · Cited by 1,496 · see citing works
An international study of the relation between somatic symptoms and depression
Simon, G. E., VonKorff, M., Piccinelli, M., Fullerton, C., & Ormel, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910283411801 · Cited by 1,303 · see citing works
The NIMH Epidemiologic Catchment Area Program
Regier, D. A. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790210016003 · Cited by 1,259 · see citing works
Chronic pain-associated depression: Antecedent or consequence of chronic pain? A review
Fishbain, D. A., Cutler, R., Rosomoff, H. L., & Rosomoff, R. S. (1997) · The Clinical Journal of Pain · doi:10.1097/00002508-199706000-00006 · Cited by 1,074 · see citing works
An epidemiologic comparison of pain complaints
Korff, M. V., Dworkin, S. F., LeResche, L., & Kruger, A. (1988) · Pain · doi:10.1016/0304-3959(88)90066-8 · Cited by 966 · see citing works
Residual symptoms after partial remission: an important outcome in depression
Paykel, E. S., Ramana, R., Cooper, Z., Hayhurst, H., Kerr, J., & Barocka, A. (1995) · Psychological Medicine · doi:10.1017/s0033291700033146 · Cited by 791 · see citing works
Physical symptoms in primary care. Predictors of psychiatric disorders and functional impairment
Kroenke, K. (1994) · Archives of Family Medicine · doi:10.1001/archfami.3.9.774 · Cited by 741 · see citing works
Self-citation
Psychosocial Predictors of Outcome in Acute and Subchronic Low Back Trouble
Burton, A. K., Tillotson, K. M., Main, C. J., & Hollis, S. (1995) · Spine · doi:10.1097/00007632-199503150-00014 · Cited by 700 · see citing works
Epidemiology of depression in primary care
Katon, W. J., & Schulberg, H. C. (1992) · General Hospital Psychiatry · doi:10.1016/0163-8343(92)90094-q · Cited by 664 · see citing works
Self-citation
Somatization and the recognition of depression and anxiety in primary care
Kirmayer, L. J., Robbins, J. M., Dworkind, M., & Yaffe⃰, M. J. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.5.734 · Cited by 601 · see citing works
Symptoms in the community. Prevalence, classification, and psychiatric comorbidity
Kroenke, K. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.21.2474 · Cited by 574 · see citing works
Self-citation
Male and female chronic pain patients categorized by DSM-III psychiatric diagnostic criteria
Fishbain, D. A., GOLDBERG, M. L., Meagher, R. B., Steele, R., & Rosomoff, H. L. (1986) · Pain · doi:10.1016/0304-3959(86)90074-6 · Cited by 560 · see citing works
Depression in Patients With Cancer
McDaniel, J. S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950140007002 · Cited by 541 · see citing works
Somatic presentation of DSM-III psychiatric disorders in primary care
Bridges, K. W., & Goldberg, D. P. (1985) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(85)90064-9 · Cited by 534 · see citing works
Disability and Depression Among High Utilizers of Health Care: A Longitudinal Analysis
Von Korff, M. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820020011002 · Cited by 523 · cited 2× · see citing works
“Unimproved back pain at short-term (7-week) and long-term (2-year) follow-up was associated with significantly more depressive symptoms and chronic depression when compared with patients whose back pain improved.(101,103,104) Over the long term, improvement in pain symptoms was associated with a decrease in depressive…”
Background
Expectation of Pain Enhances Responses to Nonpainful Somatosensory Stimulation in the Anterior Cingulate Cortex and Parietal Operculum/Posterior Insula: an Event-Related Functional Magnetic Resonance Imaging Study
Sawamoto, N., Honda, M., Okada, T., Hanakawa, T., Kanda, M., Fukuyama, H., Konishi, J., & Shibasaki, H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07438.2000 · Cited by 519 · see citing works
Imipramine in Patients with Chest Pain Despite Normal Coronary Angiograms
Cannon, R. O., Quyyumi, A. A., Mincemoyer, R., Stine, A. M., Gracely, R. H., Smith, W. B., Geraci, M. F., Black, B. C., Uhde, T. W., Waclawiw, M. A., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199405193302003 · Cited by 504 · see citing works
Depression and Chronic Medical Illness
Sachdeva, S., Cohen, D., Singh, A. K., Kaul, P., & Schwartz, T. L. (2009) · Medical psychiatry · doi:10.3109/9781420084887.012 · Cited by 495 · see citing works
The Relationship Between Pain and Depression
Korff, M. V., & Simon, G. (1996) · The British Journal of Psychiatry · doi:10.1192/s0007125000298474 · Cited by 491 · see citing works
Cognitive-behavioral therapy for somatization and symptom syndromes: a critical review of controlled clinical trials
Kroenke, K., & Swindle, R. (2000) · Psychotherapy and Psychosomatics · doi:10.1159/000012395 · Cited by 478 · see citing works
Self-citation
Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis
Jackson, J. L., O’Malley, P. G., Tomkins, G., Balden, E., Santoro, J., & Kroenke, K. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00299-5 · Cited by 464 · see citing works
Self-citation
Three Forms of Somatization in Primary Care
Kirmayer, L. J., & Robbins, J. M. (1991) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199111000-00001 · Cited by 434 · see citing works
Pain modulation: expectation, opioid analgesia and virtual pain
Fields, H. L. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62143-3 · Cited by 433 · see citing works
Medical Symptoms without Identified Pathology: Relationship to Psychiatric Disorders, Childhood and Adult Trauma, and Personality Traits
Katon, W. J., Sullivan, M. D., & Walker, E. A. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-9_part_2-200105011-00017 · Cited by 416 · see citing works
Self-citation
Back Pain in Primary Care
Korff, M. V., Deyo, R. A., Cherkin, D. C., & Barlow, W. E. (1993) · Spine · doi:10.1097/00007632-199306000-00008 · Cited by 403 · see citing works
A cross‐national study of the course of persistent pain in primary care
Gureje, O., Simon, G., & Korff, M. V. (2001) · Pain · doi:10.1016/s0304-3959(00)00483-8 · Cited by 400 · see citing works
The Relation of Pain to Depression Among Institutionalized Aged
Parmelee, P. A., Katz, I. R., & Lawton, M. P. (1991) · Journal of Gerontology · doi:10.1093/geronj/46.1.p15 · Cited by 394 · see citing works
Duloxetine, 60 mg Once Daily, for Major Depressive Disorder: A Randomized Double-Blind Placebo-Controlled Trial
Detke, M. J., Lu, Y., Goldstein, D. J., Hayes, J. R., & Demitrack, M. A. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0407 · Cited by 384 · see citing works
Influence of psychological factors on postoperative pain, mood and analgesic requirements
Taenzer, P. A., Melzack, R., & Jeans, M. E. (1986) · Pain · doi:10.1016/0304-3959(86)90119-3 · Cited by 379 · see citing works
Chronic musculoskeletal pain and depressive symptoms in the national health and nutrition examination I. Epidemiologic follow-up study
Magni, G., Marchetti, M., Moreschi, C., Merskey, H., & Luchini, S. R. (1993) · Pain · doi:10.1016/0304-3959(93)90076-2 · Cited by 374 · see citing works
Impact of pain on depression treatment response in primary care
Bair, M. J., Robinson, R. L., Eckert, G. J., Stang, P. E., Croghan, T. W., & Kroenke, K. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000106883.94059.c5 · Cited by 371 · see citing works
Chronic musculoskeletal pain and depressive symptoms in the general population. An analysis of the 1st National Health and Nutrition Examination Survey data
Magni, G., Caldieron, C., Rigatti-Luchini, S., & Merskey, H. (1990) · Pain · doi:10.1016/0304-3959(90)90027-b · Cited by 343 · see citing works
Treatment of fibromyalgia with antidepressants: A meta-analysis
O’Malley, P. G., Balden, E., Tomkins, G., Santoro, J., Kroenke, K., & Jackson, J. L. (2000) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2000.06279.x · Cited by 340 · see citing works
Self-citation
First onset of common pain symptoms: a prospective study of depression as a risk factor
Von Korff, M., Resche, L. L., & Dworkin, S. F. (1993) · Pain · doi:10.1016/0304-3959(93)90154-h · Cited by 334 · see citing works
Antidepressant therapy for unexplained symptoms and symptom syndromes.
O’Malley, P. G., Jackson, J. L., Santoro, J., Tomkins, G., Balden, E., & Kroenke, K. (1999) · PubMed · Cited by 329 · see citing works
Self-citation
Psychologic Distress and Low Back Pain
Croft, P. R., Papageorgiou, A. C., Ferry, S., Thomas, E., Jayson, M. I. V., & Silman, A. J. (1995) · Spine · doi:10.1097/00007632-199512150-00015 · Cited by 327 · see citing works
Predicting Poor Outcomes for Back Pain Seen in Primary Care Using Patientsʼ Own Criteria
Cherkin, D. C., Deyo, R. A., Street, J. H., & Barlow, W. E. (1996) · Spine · doi:10.1097/00007632-199612150-00023 · Cited by 300 · see citing works
Back pain in primary care: predictors of high health-care costs
Engel, C. C., Korff, M. V., & Katon, W. J. (1996) · Pain · doi:10.1016/0304-3959(95)00164-6 · Cited by 291 · see citing works
Self-citation
Depressive and Anxiety Disorders in Patients Presenting With Physical Complaints
Kroenke, K., Jackson, J. L., & Chamberlin, J. (1997) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00241-6 · Cited by 291 · see citing works
Competing demands in psychosocial care. A model for the identification and treatment of depressive disorders in primary care.
Klinkman, M. (1997) · General Hospital Psychiatry · doi:10.1016/s0163-8343(96)00145-4 · Cited by 284 · see citing works
Depressive and distress symptoms as predictors of low back pain, neck-shoulder pain, and other musculoskeletal morbidity: a 10-year follow-up of metal industry employees
Leino, P., & Magni, G. (1993) · Pain · doi:10.1016/0304-3959(93)90060-3 · Cited by 277 · see citing works
Pain and depression in patients with cancer
Spiegel, D., Sands, S. H., & Koopman, C. (1994) · Cancer · doi:10.1002/1097-0142(19941101)74:9 · Cited by 270 · see citing works
Chronic pain: lifetime psychiatric diagnoses and family history
Katon, W. J., Egan, K. J., & Miller, D. (1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.10.1156 · Cited by 259 · see citing works
Self-citation
Evidence-based data on pain relief with antidepressants
Fishbain, D. A. (2000) · Annals of Medicine · doi:10.3109/07853890008995932 · Cited by 256 · see citing works
The treatment of depression in chronic low back pain: review and recommendations
Sullivan, M. J. L., Reesor, K., Mikail, S. F., & Fisher, R. (1992) · Pain · doi:10.1016/0304-3959(92)90107-m · Cited by 246 · see citing works
Antidepressants as analgesics: a review of randomized controlled trials.
Lynch, M. E. (2001) · PubMed · Cited by 242 · see citing works
Long-term medical conditions and major depression in a Canadian population study at waves 1 and 2
Patten, S. B. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00186-5 · Cited by 238 · see citing works
Pain relief by antidepressants: Possible modes of action
Feinmann, C. (1985) · Pain · doi:10.1016/0304-3959(85)90223-4 · Cited by 233 · see citing works
The depression-pain syndrome and its response to antidepressants
Lindsay, P. G., & Wyckoff, M. (1981) · Psychosomatics · doi:10.1016/s0033-3182(81)73478-9 · Cited by 232 · see citing works
Psychosocial Correlates and Impact of Chronic Tension‐type Headaches
Holroyd, K. A., Stensland, M. D., Lipchik, G. L., Hill, K. R., O'donnell, F., & Cordingley, G. E. (2000) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2000.00001.x · Cited by 232 · see citing works
Clinical aspects of depression in chronic pain patients.
Dworkin, R., & Gitlin, M. (1991) · The Clinical Journal of Pain · doi:10.1097/00002508-199106000-00004 · Cited by 229 · see citing works
Atypical Facial Pain and Depression
Lascelles, R. G. (1966) · The British Journal of Psychiatry · doi:10.1192/bjp.112.488.651 · Cited by 217 · see citing works
Psychogenic facial pain: presentation and treatment.
Feinmann, C., Harris, M., & Cawley, R. H. (1984) · BMJ · doi:10.1136/bmj.288.6415.436 · Cited by 196 · see citing works
Predictors of Low Back Pain Onset in a Prospective British Study
Power, C., Frank, J. W., Hertzman, C., Schierhout, G., & Li, L. (2001) · American Journal of Public Health · doi:10.2105/ajph.91.10.1671 · Cited by 189 · see citing works
Longitudinal relationship between pain and depression in older adults: sex, age and physical disability
Geerlings, S. W., Twisk, J. W. R., Beekman, A. T. F., Deeg, D. J. H., & van Tilburg, W. (2002) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s127-002-8210-2 · Cited by 183 · see citing works
Studying Symptoms: Sampling and Measurement Issues
Kroenke, K. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-9_part_2-200105011-00008 · Cited by 183 · see citing works
Self-citation
Affective, substance use, and anxiety disorders in persons with arthritis, diabetes, heart disease, high blood pressure, or chronic lung conditions
Wells, K. B., Golding, J. M., & Burnam, M. A. (1989) · General Hospital Psychiatry · doi:10.1016/0163-8343(89)90119-9 · Cited by 181 · see citing works
Predicting long-term functional limitations among back pain patients in primary care settings
Dionne, C. E., Koepsell, T. D., Korff, M. V., Deyo, R. A., Barlow, W. E., & Checkoway, H. (1997) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(96)00313-7 · Cited by 176 · see citing works
The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression
Ward, N. G., Bloom, V. L., & Friedel, R. O. (1979) · Pain · doi:10.1016/0304-3959(79)90089-7 · Cited by 173 · see citing works
Factors that modify the association between knee pain and mobility limitation in older women: the Women's Health and Aging Study
Lamb, S. E., Guralnik, J., Buchner, D., Ferrucci, L., Hochberg, M., Simonsick, E., & Fried, L. (2000) · Annals of the Rheumatic Diseases · doi:10.1136/ard.59.5.331 · Cited by 172 · see citing works
Putative mechanisms of action of antidepressant drugs in affective and anxiety disorders and pain.
Blier, P., & Abbott, F. V. (2001) · PubMed Central · Cited by 168 · see citing works
The burden of depression in patients with rheumatoid arthritis
Dickens, C. M. (2001) · British journal of rheumatology · doi:10.1093/rheumatology/40.12.1327 · Cited by 162 · see citing works
Evolution of remission as the new standard in the treatment of depression.
Nierenberg, A. A., & Wright, E. (1999) · PubMed · Cited by 161 · see citing works
On the relationship between chronic pain and depression when there is no organic lesion
Magni, G. (1987) · Pain · doi:10.1016/0304-3959(87)90002-9 · Cited by 153 · see citing works
Physical Symptoms of Depression
Mathew, R. J., Weinman, M. L., & Mirabi, M. (1981) · The British Journal of Psychiatry · doi:10.1192/bjp.139.4.293 · Cited by 153 · see citing works
Depression among chronic pain patients: Cognitive-behavioral analysis and effect on rehabilitation outcome.
Kerns, R. D., & Haythornthwaite, J. A. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.56.6.870 · Cited by 152 · see citing works
Cardiovascular effects of antidepressants.
Hameroff, S. R., Cork, R. C., Scherer, K., Crago, B. R., Neuman, C., Womble, J. R., & Davis, T. P. (1982) · PubMed · Cited by 150 · see citing works
Are patients with chronic pain depressed?
Kramlinger, K. G., Swanson, D. W., & Maruta, T. (1983) · American Journal of Psychiatry · doi:10.1176/ajp.140.6.747 · Cited by 144 · see citing works
Depression: relationship to somatization and chronic medical illness.
Katon, W. J. (1984) · PubMed · Cited by 143 · see citing works
Self-citation
The relationship of presenting physical complaints to depressive symptoms in primary care patients
Gerber, P. D., Barrett, J. E., Barrett, J. A., Oxman, T. E., Manheimer, E., Smith, R., & Whiting, R. D. (1992) · Journal of General Internal Medicine · doi:10.1007/bf02598007 · Cited by 143 · see citing works
Psychiatric diagnosis of chronic pain patients
Reich, J. H., Tupin, J. P., & Abramowitz, S. I. (1983) · American Journal of Psychiatry · doi:10.1176/ajp.140.11.1495 · Cited by 140 · see citing works
Depression in chronic pain patients: Relation to pain, activity, and sex differences
Haley, W. E., Turner, J. A., & Romano, J. M. (1985) · Pain · doi:10.1016/0304-3959(85)90003-x · Cited by 139 · see citing works
Treatment of chronic headache with antidepressants: a meta-analysis
Tomkins, G., Jackson, J. L., O’Malley, P. G., Balden, E., & Santoro, J. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00762-8 · Cited by 137 · see citing works
Managing pain and comorbid depression: A public health challenge.
Gallagher, R. M., & Verma, S. (1999) · PubMed · Cited by 133 · see citing works
Association between major depressive disorder and physical illness
Moldin, S. O., Scheftner, W. A., Rice, J. P., Nelson, E. C., Knesevich, M. A., & Akiskal, H. S. (1993) · Psychological Medicine · doi:10.1017/s0033291700025526 · Cited by 133 · see citing works
Depression among high utilizers of medical care
Pearson, S. D., Katzelnick, D. J., Simon, G. E., Manning, W. G., Helstad, C. P., & Henk, H. J. (1999) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1999.06278.x · Cited by 131 · see citing works
Psychiatric Diagnoses and Sexual Victimization in Women With Chronic Pelvic Pain
Walker, E. A., Katon, W. J., Hansom, J., Harrop-Griffiths, J., Holm, L., Jones, M. L., Hickok, L. R., & Russo, J. E. (1995) · Psychosomatics · doi:10.1016/s0033-3182(95)71608-5 · Cited by 129 · see citing works
Self-citation
Depression Masquerading as Diabetic Neuropathy
Turkington, R. W. (1981) · The Science of Diabetes Self-Management and Care · doi:10.1177/263501068100700114 · Cited by 129 · see citing works
Biofeedback and relaxation training with three kinds of headache: Treatment effects and their prediction.
Blanchard, E. B., & al, E. (1982) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.50.4.562 · Cited by 126 · see citing works
Pain as a symptom in depressive disorders. I. Relationship to diagnostic subgroup and depressive symptomatology
von Knorring, L., Perris, C., Eisemann, M. R., Eriksson, U., & Perris, H. (1983) · Pain · doi:10.1016/0304-3959(83)90003-9 · Cited by 125 · see citing works
A controlled study of amitriptyline in the treatment of chronic pain
Pilowsky, I., Hallett, E. C., Bassett, D. L., Thomas, P., & Penhall, R. K. (1982) · Pain · doi:10.1016/0304-3959(82)90097-5 · Cited by 124 · see citing works
Psychological disorders in rheumatoid arthritis: a growing consensus?
Creed, F. H. (1990) · Annals of the Rheumatic Diseases · doi:10.1136/ard.49.10.808 · Cited by 121 · see citing works
Chronic pain and depression. II. Symptoms of anxiety in chronic low back pain patients and their relationship to subtypes of depression
Krishnan, R. R., France, R. D., Pelton, S., McCann, U. D., Davidson, J. R. T., & Urban, B. J. (1985) · Pain · doi:10.1016/0304-3959(85)90029-6 · Cited by 120 · see citing works
The Efficacy of Selective Serotonin Reuptake Inhibitors for the Management of Chronic Pain
Jung, A. C., Staiger, T. O., & Sullivan, M. D. (1997) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1997.00064.x · Cited by 119 · see citing works
Patients' reasons for not presenting emotional problems in general practice consultations.
Cape, J. D., & McCulloch, Y. (1999) · PubMed · Cited by 119 · see citing works
Impact of improved depression treatment in primary care on daily functioning and disability
Simon, G. E., Katon, W. J., Rutter, C. M., VonKorff, M., Lin, E. H. B., ROBINSON, P., Bush, T. M., Walker, E. A., Ludman, E. J., & Russo, J. E. (1998) · Psychological Medicine · doi:10.1017/s0033291798006588 · Cited by 119 · see citing works
Self-citation
Theoretical and empirical issues in the treatment of post-traumatic stress disorder in Vietnam veterans
Fairbank, J. A., & Nicholson, R. A. (1987) · Journal of Clinical Psychology · doi:10.1002/1097-4679(198701)43:1 · Cited by 116 · see citing works
The treatment of chronic pain with psychotropic drugs
Merskey, H., & Hester, R. (1972) · Postgraduate Medical Journal · doi:10.1136/pgmj.48.564.594 · Cited by 110 · see citing works
A double-blind controlled study of a serotonin uptake inhibitor (Zimelidine) versus placebo in chronic pain patients
Johansson, F., & von Knorring, L. (1979) · Pain · doi:10.1016/0304-3959(79)90108-8 · Cited by 109 · see citing works
The Experience of Pain in Depressed Patients
von Knorring, L. (2008) · Neuropsychobiology · doi:10.1159/000117488 · Cited by 109 · see citing works
Depression in primary care: changes in pattern of patient visits and complaints during a developing depression.
Rb, W., & Cadoret, R. J. (1978) · PubMed · Cited by 108 · see citing works
Assessing benefits of the pain center: Why some patients regress
Painter, J. R., Seres, J. L., & Newman, R. I. (1980) · Pain · doi:10.1016/0304-3959(80)90093-7 · Cited by 106 · see citing works
Biofeedback and relaxation training with three kinds of headache: Treatment effects and their prediction.
Blanchard, E. B., Andrasik, F. J., Neff, D. F., et al. (1982) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.50.4.562 · Cited by 106 · see citing works
Does Depression Hurt?
Stahl, S. M. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0401 · Cited by 105 · see citing works
Clomipramine and mianserin in chronic idiopathic pain syndrome
Loldrup, D., Langemark, M., Hansen, H., et al. (1989) · Psychopharmacology · doi:10.1007/bf00634443 · Cited by 105 · see citing works
The Relationship Between Pain and Depression in a Trial Using Paroxetine in Sufferers of Chronic Low Back Pain
Dickens, C. M., Jayson, M. I. V., Sutton, C., & Creed, F. H. (2000) · Psychosomatics · doi:10.1176/appi.psy.41.6.490 · Cited by 101 · see citing works
Controlled trial of imipramine for chronic low back pain.
Alcoff, J., Jones, E. T., Rust, P., & Newman, R. (1982) · PubMed · Cited by 100 · see citing works
The Efficacy of Selective Serotonin Reuptake Inhibitors for the Management of Chronic Pain
Jung, A. C., Staiger, T. O., & Sullivan, M. D. (1997) · Journal of General Internal Medicine · doi:10.1007/s11606-006-5088-3 · Cited by 96 · see citing works
Relationships between depressive symptoms and descriptions of chronic pain
Doan, B. D., & Wadden, N. P. (1989) · Pain · doi:10.1016/0304-3959(89)90113-9 · Cited by 95 · see citing works
Prediction of outcome among chronic pain patients
Dolce, J. J., Crocker, M. F., & Doleys, D. M. (1986) · Behaviour Research and Therapy · doi:10.1016/0005-7967(86)90191-9 · Cited by 92 · see citing works
Physical and psychological evaluation of 'non-organic' abdominal pain.
Hill, O. W., & Blendis, L. M. (1967) · Gut · doi:10.1136/gut.8.3.221 · Cited by 92 · see citing works
A National Study of the Effect of Chronic Pain on the Use of Health Care by Depressed Persons
Bao, Y., Sturm, R., & Croghan, T. W. (2003) · Psychiatric Services · doi:10.1176/appi.ps.54.5.693 · Cited by 88 · see citing works
Screening for psychiatric morbidity. The pattern of psychological illness and premorbid characteristics in four chronic pain populations
Merskey, H., Lau, C. L., Russell, E. S., Brooke, R. I., James, M., Lappano, S., Neilsen, J., & Tilsworth, R. H. (1987) · Pain · doi:10.1016/0304-3959(87)91070-0 · Cited by 86 · see citing works
Tofranil in the treatment of low back pain.
Dg, J., Af, E., & Cd, E. (1976) · PubMed · Cited by 85 · see citing works
The Saskatchewan Health and Back Pain Survey: The Prevalence and Factors Associated with Depressive Symptomatology in Saskatchewan Adults
Carroll, L., Cassidy, J. D., & Côté, P. (2000) · Canadian Journal of Public Health · doi:10.1007/bf03404830 · Cited by 83 · see citing works
Chronic pain and depression: a clinical and family history survey
Schaffer, C. B., Donlon, P. T., & Bittle, R. M. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.1.118 · Cited by 78 · see citing works
Comorbidity of headaches and depression in the elderly
Wang, S., Liu, H.-C., Fuh, J., Liu, C., Wang, P., & Lu, S. (1999) · Pain · doi:10.1016/s0304-3959(99)00057-3 · Cited by 78 · see citing works
Part II: A ospective DSM-III study of 100 consecutive somatization patients
Katon, W. J., Ries, R. K., & Kleinman, A. (1984) · Comprehensive Psychiatry · doi:10.1016/0010-440x(84)90063-4 · Cited by 77 · see citing works
Self-citation
Doxepin's effects on chronic pain and depression: a controlled study.
Hameroff, S. R., Weiss, J. L., Lerman, J. C., Cork, R. C., Watts, K. S., Crago, B. R., Neuman, C. P., Womble, J. R., & Davis, T. P. (1984) · PubMed · Cited by 77 · see citing works
DSM-III Diagnoses in Chronic Pain
Large, R. G. (1986) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198605000-00006 · Cited by 76 · see citing works
Significance of pain in psychiatric hospital patients
Delaplaine, R. P., Ifabumuyi, O. I., Merskey, H., & Zarfas, J. (1977) · Pain · doi:10.1016/0304-3959(77)90146-4 · Cited by 75 · see citing works
Predicting treatment response in depressed and non-depressed chronic pain patients
Dworkin, R. H., Richlin, D. M., Handlin, D. S., & Brand, L. J. (1986) · Pain · doi:10.1016/0304-3959(86)90120-x · Cited by 71 · see citing works
The concept of pain
Merskey, H., & Spear, F. G. (1967) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(67)90057-8 · Cited by 71 · see citing works
A clinical trial of Tofranil in rheumatic pain in general practice.
Gringras, M. (1976) · PubMed · Cited by 67 · see citing works
Acute Effects of Fluoxetine Versus
Heiligenstein, J. H., Ware, J. E., Beusterien, K. M., Roback, P., Andrejasich, C. M., & Tollefson, G. D. (1995) · International Psychogeriatrics · doi:10.1017/s1041610295002407 · Cited by 67 · see citing works
Somatic symptoms
Wilson, D. R., Widmer, R. B., Cadoret, R. J., & Judiesch, K. (1983) · Journal of Affective Disorders · doi:10.1016/0165-0327(83)90042-3 · Cited by 66 · see citing works
Chronic Tension‐Type Headache, Mood Depression and Serotonin: Therapeutic Effects of Fluvoxamine and Mianserine
Manna, V., Bolino, F., & Cicco, L. D. (1994) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.1994.hed3401044.x · Cited by 64 · see citing works
Competing demands
Williams, J. W. (1998) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1998.00032.x · Cited by 61 · see citing works
The relationship of chronic pain, mental illness and organic disorders
Benjamin, S., Barnes, D., Berger, S., Clarke, I., & Jeacock, J. (1988) · Pain · doi:10.1016/0304-3959(88)90067-x · Cited by 60 · see citing works
Psychogenic facial pain: Presentation and treatment
Feinmann, C. (1983) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(83)90076-4 · Cited by 59 · see citing works
Neuroticism and Extraversion as Predictors of Health Outcomes in Depressed Primary Care Patients
Russo, J. E., Katon, W. J., Lin, E. H. B., Korff, M. V., Bush, T. M., Simon, G., & Walker, E. A. (1997) · Psychosomatics · doi:10.1016/s0033-3182(97)71441-5 · Cited by 57 · see citing works
Self-citation
The evolution of chronic pain among patients with musculoskeletal problems: a pilot study in primary care.
Potter, R., & Jones, J. M. (1992) · PubMed · Cited by 56 · see citing works
Depressed mood in chronic low back pain: Relationship with stressful life events
Atkinson, J. H., Slater, M. A., Grant, I., Patterson, T. L., & Garfin, S. R. (1988) · Pain · doi:10.1016/0304-3959(88)90275-8 · Cited by 56 · see citing works
Treatment-Resistant Depression: Progress and Limitations
O’Reardon, J. P., & Amsterdam, J. D. (1998) · Psychiatric Annals · doi:10.3928/0048-5713-19981101-08 · Cited by 55 · see citing works
Chronic Pelvic Pain and Depression
Magni, G., Salmi, A., Leo, D. D., & Ceola, A. (2010) · Psychopathology · doi:10.1159/000284030 · Cited by 54 · see citing works
Is Chronic Pain a Variant of Depressive Illness? A Critical Review
Gupta, M. A. (1986) · The Canadian Journal of Psychiatry · doi:10.1177/070674378603100312 · Cited by 52 · see citing works
Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared.
Gelenberg, A. J., Jd, W., Lydiard, R. B., McCormick, M. G., Falk, W. E., Hicks, R. H., Curren, F. C., & Cohen, B. M. (1984) · PubMed · Cited by 50 · see citing works
Depression in family practice: changes in pattern of patient visits and complaints during subsequent developing depressions.
Rb, W., & Cadoret, R. J. (1979) · PubMed · Cited by 48 · see citing works
Psychiatric Disorders Associated with Atypical Facial Pain
Remick, R. A., Blasberg, B., Campos, P. E., et al. (1983) · The Canadian Journal of Psychiatry · doi:10.1177/070674378302800304 · Cited by 47 · see citing works
MASKED DEPRESSION IN MEN WITH LOW BACK PAIN
Forrest, A. J., & Wolkind, S. N. (1974) · Lara D. Veeken · doi:10.1093/rheumatology/13.3.148 · Cited by 47 · see citing works
Venlafaxine for the treatment of chronic pain
Songer, D. A., & Schulte, H. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.5.737a · Cited by 47 · see citing works
Psychologic characteristics of psychiatric patients having pain as a presenting symptom.
Pilling, L. F., Brannick, T. L., & Swenson, W. M. (1967) · PubMed · Cited by 41 · see citing works
A controlled study of a serotonin reuptake blocker, zimelidine, in the treatment of chronic pain
Gourlay, G. K., Cherry, D. A., Cousins, M. J., et al. (1986) · Pain · doi:10.1016/0304-3959(86)90006-0 · Cited by 41 · see citing works
The Diagnosis of Depression
Mayer-Groß, W. (1954) · BMJ · doi:10.1136/bmj.2.4894.948 · Cited by 41 · see citing works
Cholecystokinin and enkephalin in brain stem pain modulating circuits
Skinner, K., Basbaum, A. I., & Fields, H. L. (1997) · Neuroreport · doi:10.1097/00001756-199709290-00001 · Cited by 40 · see citing works
Depression masquerading as diabetic neuropathy
Turkington, R. W. (1980) · JAMA · doi:10.1001/jama.243.11.1147 · Cited by 40 · see citing works
Stress-related, posttraumatic chronic pain syndrome: Criteria for diagnosis, and preliminary report on prevalence
Muse, M. D. (1985) · Pain · doi:10.1016/0304-3959(85)90108-3 · Cited by 39 · see citing works
A new look at low back complaints in primary care: a RAMBAM Israeli Family Practice Research Network study.
Reis, S., Hermoni, D., Borkan, J. M., Biderman, A., Tabenkin, C., & Porat, A. (1999) · PubMed · Cited by 39 · see citing works
Treatment of the painful shoulder syndrome with amitriptyline and lithium carbonate.
Tyber, M. A. (1974) · PubMed · Cited by 39 · see citing works
The Mild Endogenous Depression
Watts, C. A. H. (1957) · BMJ · doi:10.1136/bmj.1.5009.4 · Cited by 37 · see citing works
MMPI Subgroups and Affective Disorder in Chronic Pain Patients
Atkinson, J. H., Ingram, R. E., Kremer, E. F., et al. (1986) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198607000-00004 · Cited by 36 · see citing works
Psychosocial Care by General Practitioners—Where are the Problems? Results of a Demonstration Project on Quality Management in Psychosocial Primary Care
Fritzsche, K., Sandholzer, H., Brucks, U., Cierpka, M., Deter, H., Härter, M. C., Höger, C., Richter, R., Schmidt, B., Larisch, A., et al. (1999) · The International Journal of Psychiatry in Medicine · doi:10.2190/mcgf-cld4-0fre-n2uk · Cited by 35 · see citing works
Antidepressants in the medically ill: diagnosis and treatment in primary care.
Katon, W. J., & Roy‐Byrne, P. (1988) · Clinical Chemistry · doi:10.1093/clinchem/34.5.829 · Cited by 34 · see citing works
Self-citation
Women and somatization: Unrecognized depression
Betrus, P. A., Elmore, S. K., & Hamilton, P. (1995) · Health Care For Women International · doi:10.1080/07399339509516182 · Cited by 34 · see citing works
Chronic low‐back pain and depression: an epidemiological survey
Magni, G. (1984) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1984.tb01256.x · Cited by 34 · see citing works
Depression as a psychopathological disorder in chronic low back pain patients
France, R. D., Houpt, J. L., Skott, A., Krishnan, K., & Varia, I. M. (1986) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(86)90041-3 · Cited by 32 · see citing works
Comparison of two dosage regimens of fluoxetine in major depression.
Rickels, K., Smith, W. T., Glaudin, V., Jb, A., Weise, C. C., & Settle, G. (1985) · PubMed · Cited by 32 · see citing works
Systematic treatment of chronic pain with antidepressants.
Blumer, D. P., Heilbronn, M., Pedraza, E., et al. (1980) · PubMed · Cited by 31 · see citing works
A simple examination of the relationships between pain, organic lesions and psychiatric illness
Magni, G., & Merskey, H. (1987) · Pain · doi:10.1016/0304-3959(87)90044-3 · Cited by 31 · see citing works
Anxiety and Depression in an Outpatient Clinic in Lesotho, Africa
Hollifield, M. A., Katon, W. J., & Morojele, N. K. (1994) · The International Journal of Psychiatry in Medicine · doi:10.2190/x3xa-lpjb-c3kw-amly · Cited by 30 · see citing works
Self-citation
'Minor' illness symptoms. The magnitude of their burden and of our ignorance
Komaroff, A. L. (1990) · Archives of Internal Medicine · doi:10.1001/archinte.150.8.1586 · Cited by 27 · see citing works
Eliza as a “therapeutic” tool
O’Dell, J. W., & Dickson, J. (1984) · Journal of Clinical Psychology · doi:10.1002/1097-4679(198407)40:4 · Cited by 27 · see citing works
Effects of electrical stimulation of thalamic nucleus submedius and periaqueductal gray on the visceral nociceptive responses of spinal dorsal horn neurons in the rat
Okada, K., Murase, K., & Kawakita, K. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01593-0 · Cited by 26 · see citing works
Highly δ selective antagonists in the RVM attenuate the antinociceptive effect of PAG DAMGO
Hirakawa, N., Tershner, S. A., & Fields, H. L. (1999) · Neuroreport · doi:10.1097/00001756-199910190-00001 · Cited by 26 · see citing works
Tertiary gain and chronic pain
Bokan, J. A., Ries, R. K., & Katon, W. J. (1981) · Pain · doi:10.1016/0304-3959(81)90093-2 · Cited by 25 · see citing works
Self-citation
Clinical factors associated with short-term changes in outcome of patients with somatized mental disorder in primary care
Downes-Grainger, E., Morriss, R. K., Gask, L. L., & Faragher, B. E. (1998) · Psychological Medicine · doi:10.1017/s0033291798006552 · Cited by 25 · see citing works
Evaluating and treating co-morbid pain and depression
Verma, S., & Gallagher, R. M. (2000) · International Review of Psychiatry · doi:10.1080/09540260050007426 · Cited by 24 · see citing works
'Minor' Illness Symptoms
Komaroff, A. L. (1990) · Archives of Internal Medicine · doi:10.1001/archinte.1990.00040031586003 · Cited by 23 · see citing works
The prevalence of current major depression and dysthymia in a Norwegian general practice
Værø, H., & Merskey, H. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb09639.x · Cited by 23 · see citing works
Second-year follow-up study on systematic treatment of chronic pain with antidepressants.
Blumer, D. P., & Heilbronn, M. (1981) · PubMed · Cited by 20 · see citing works
A new method for treating "headaches"
Sherwin, D. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.136.9.1181 · Cited by 20 · see citing works
Breast pain associated with venlafaxine.
Bhatia, S. C., Gupta, S. K. D., & Theesen, K. A. (1996) · PubMed · Cited by 16 · see citing works
A Therapeutic Milieu for Chronic Pain Patients
Newman, R. I., Painter, J. R., & Seres, J. L. (1978) · Journal of Human Stress · doi:10.1080/0097840x.1978.9934980 · Cited by 16 · see citing works
Depressed and non-depressed chronic pain patients
Chaturvedi, S. K. (1987) · Pain · doi:10.1016/0304-3959(87)90050-9 · Cited by 16 · see citing works
Patterns of Depression in Chronic Illness
Covino, N. A., Dirks, J. F., Kinsman, R. A., et al. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000287567 · Cited by 15 · see citing works
Drug treatment of chronic intractable pain in patients referred to a psychiatry clinic.
Singh, G., & Hc, V. (1971) · PubMed · Cited by 13 · see citing works
Doxepin??s effects on chronic pain and depression
Hameroff, S. R., Weiss, J. L., Lerman, J. C., et al. (1984) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198408000-00024 · Cited by 12 · see citing works
A note on the occurence of pain in psychiatric patients from a Canadian Indian and inuit population
Pelz, M., Merskey, H., Brant, C., & Heseltine, G. F. D. (1981) · Pain · doi:10.1016/0304-3959(81)90047-6 · Cited by 11 · see citing works
Denial in the Depressive and Pain-Prone Disorders of Chronic Pain
Bouckoms, A. J., Litman, R. E., & Baer, L. (1985) · Clinical Journal of Pain · doi:10.1097/00002508-198501030-00007 · Cited by 11 · see citing works
Denial in the depressive and pain prone disorders of chronic pain
Bouckoms, A. J., Litman, R. E., & Baer, L. (1984) · Pain · doi:10.1016/0304-3959(84)90447-0 · Cited by 5 · see citing works
A comparison of depressed and anxious chronic pain patients
Chaturvedi, S. K. (1987) · General Hospital Psychiatry · doi:10.1016/0163-8343(87)90074-0 · Cited by 4 · see citing works
Psychiatry Masked depression in men with low back pain
Forrest, A. J., & Wolkind, S. N. (1976) · Pain · doi:10.1016/0304-3959(76)90102-0 · Cited by 3 · see citing works
Mild Endogenous Depression
Woodland, R. J. T. (1957) · BMJ · doi:10.1136/bmj.1.5011.167-a · Cited by 3 · see citing works
A Controlled Study of a Serotonin Reuptake Blocker, Zimelidine, in the Treatment of Chronic Pain
Gourlay, G. K., Cherry, D. A., Cousins, M. J., et al. (1987) · Survey of Anesthesiology · doi:10.1097/00132586-198704000-00023 · Cited by 2 · see citing works

Flagged first, then by citations

Research works printed but not linked: 10

[50]50. Turner JA, Romano JM. Self-report screening measures for depression in chronic pain pa- tients. J Clin Psychol. 1984;40:909-913.
[59]59. Katon W, Ries RK, Kleinman A. A prospective DSM-III study of 100 consecutive somatization patients. Compr Psychiatry. 1984;25:305-314.
[71]71. Lascelles RG. Atypical facial pain and depres- sion. Br J Psychiatry. 1966;112:651-659.
[74]74. Love AW. Depression in chronic low back pain patients: diagnostic efficiency of three self- report questionnaires. J Clin Psychol. 1987;43: 84-89.
[76]76. Holroyd KA, Stensland M, Lipchik GL, Hill KR, O'Donnell FS, Cordingley G. Psychosocial cor- relates and impact of chronic tension-type head- aches. Headache. 2000;40:3-16.
[111]111. Elkin I, Shea MT, Watkins JT, et al. National In- stitute of Mental Health Treatment of Depres- sion Collaborative Research Program: general ef- fectiveness of treatments. Arch Gen Psychiatry. 1989;46:971-982.
[130]130. Smith MS, Womack WM, Chen ACN. Intrinsic pa- tient variables and outcome in the behavioral treatment of recurrent pediatric headache. In: Tyler DC, Krane EJ, eds. Pediatric Pain (Ad- vances in Pain Research and Therapy). New York, NY: Raven Press;1990.
[133]133. Blumer D, Heilbronn M, Pedraza E, Pope G. Sys- tematic treatment of chronic pain with antide- pressants. Henry Ford Hosp Med J. 1980;28: 15-21.
[162]162. Skinner K, Basbaum AI, Fields HL. Cholecysto- kinin and enkephalin in brain stem pain modu- lating circuits. Neuroreport. 1997;8:2995- 2998.
[172]172. Verma S, Gallagher RM. Evaluating and treat- ing comorbid pain and depression. Int Rev Psy- chiatry. 2000;12:103-114.

Sorted by citations

Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society.
Chou, R., Qaseem, A., Snow, V., Casey, D., Cross, J. T., Shekelle, P., Owens, D. K., & for the Clinical Efficacy Assessment Subcommittee of the American College of Physicians and the American College of Physicians/American Pain Society Low Back Pain Guidelines Panel* (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-7-200710020-00006 · Cited by 2,718 · see citing works
From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · see citing works
Pain as a global public health priority
Goldberg, D. S., & McGee, S. J. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-770 · Cited by 1,471 · see citing works
Common Chronic Pain Conditions in Developed and Developing Countries: Gender and Age Differences and Comorbidity With Depression-Anxiety Disorders
Tsang, A., Von Korff, M., Lee, S., Alonso, J., Karam, E., Angermeyer, M. C., Borges, G. L. G., Bromet, E. J., de Girolamo, G., de Graaf, R., et al. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2008.05.005 · Cited by 1,157 · see citing works
The role of psychosocial processes in the development and maintenance of chronic pain
Edwards, R. R., Dworkin, R. H., Sullivan, M. D., Turk, D. C., & Wasan, A. D. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.01.001 · Cited by 954 · see citing works
Multimorbidity and depression: A systematic review and meta-analysis
Read, J. R., Sharpe, L., Modini, M., & Dear, B. F. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.06.009 · Cited by 869 · see citing works
Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders
Malhi, G. S., Bassett, D., Boyce, P., Bryant, R., Fitzgerald, P. B., Fritz, K., Hopwood, M., Lyndon, B., Mulder, R., Murray, G., et al. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415617657 · Cited by 842 · see citing works
“Medical comorbidities – particularly chronic pain – appear to reduce antidepressant efficacy (Bair et al., 2003; Howland et al., 2008; Pohle et al., 2009), but antidepressants still appear to have efficacy over placebo (Gill and Hatcher, 2000).”
Background
Impact of psychological factors in the experience of pain
Linton, S. J., & Shaw, W. S. (2011) · Physical Therapy · doi:10.2522/ptj.20100330 · Cited by 819 · see citing works
Development and initial validation of the PEG, a three-item scale assessing pain intensity and interference
Krebs, E. E., Lorenz, K. A., Bair, M. J., Damush, T. M., Wu, J., Sutherland, J. M., Asch, S. M., & Kroenke, K. (2009) · Journal of General Internal Medicine · doi:10.1007/s11606-009-0981-1 · Cited by 782 · see citing works
Self-citation
Overtreating chronic back pain: time to back off?
Deyo, R. A., Mirza, S. K., Turner, J. A., & Martin, B. I. (2009) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2009.01.080102 · Cited by 796 · see citing works
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719 · see citing works
Early identification and management of psychological risk factors (“Yellow Flags”) in patients with low back pain: a reappraisal
Nicholas, M. K., Linton, S. J., Watson, P. J., & Main, C. J. (2011) · Physical Therapy · doi:10.2522/ptj.20100224 · Cited by 690 · see citing works
The influence of negative emotions on pain: Behavioral effects and neural mechanisms
Wiech, K., & Tracey, I. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.059 · Cited by 614 · see citing works
Chronic spinal pain and physical–mental comorbidity in the United States: results from the national comorbidity survey replication
Von Korff, M., Crane, P., Lane, M., Miglioretti, D. L., Simon, G., Saunders, K., Stang, P., Brandenburg, N., & Kessler, R. (2005) · Pain · doi:10.1016/j.pain.2004.11.010 · Cited by 612 · see citing works
Mental disorders among persons with chronic back or neck pain: results from the World Mental Health Surveys
Demyttenaere, K., Bruffaerts, R., Lee, S., Posada-Villa, J., Kovess, V., Angermeyer, M. C., Levinson, D., de Girolamo, G., Nakane, H., Mneimneh, Z., et al. (2007) · Pain · doi:10.1016/j.pain.2007.01.022 · Cited by 608 · see citing works
Effect of Improving Depression Care on Pain and Functional Outcomes Among Older Adults With Arthritis: A Randomized Controlled Trial
Lin, E. H. B., Katon, W., Von Korff, M., Tang, L., Williams, Jr., Kroenke, K., Hunkeler, E., Harpole, L., Hegel, M., Arean, P., et al. (2003) · JAMA · doi:10.1001/jama.290.18.2428 · Cited by 590 · see citing works
Self-citation
Reciprocal Relationship Between Pain and Depression: A 12-Month Longitudinal Analysis in Primary Care
Kroenke, K., Wu, J., Bair, M. J., Krebs, E. E., Damush, T. M., & Tu, W. (2011) · The Journal of Pain · doi:10.1016/j.jpain.2011.03.003 · Cited by 573 · see citing works
Self-citation
Association of depression and anxiety alone and in combination with chronic musculoskeletal pain in primary care patients
Bair, M. J., Wu, J., Damush, T. M., Sutherland, J. M., & Kroenke, K. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318185c510 · Cited by 572 · see citing works
Self-citation
Depression and anxiety associated with three pain conditions: Results from a nationally representative sample
McWilliams, L. A., Goodwin, R. D., & Cox, B. J. (2004) · Pain · doi:10.1016/j.pain.2004.06.002 · Cited by 562 · see citing works
Mindfulness meditation for the treatment of chronic low back pain in older adults: a randomized controlled pilot study
Morone, N. E., Greco, C. M., & Weiner, D. K. (2008) · Pain · doi:10.1016/j.pain.2007.04.038 · Cited by 546 · see citing works
Persistent pain after breast cancer treatment: a critical review of risk factors and strategies for prevention
Andersen, K. G., & Kehlet, H. (2011) · The Journal of Pain · doi:10.1016/j.jpain.2010.12.005 · Cited by 523 · see citing works
Pain and Depression: A Systematic Review
IsHak, W. W., Wen, R. Y., Naghdechi, L., Vanle, B., Dang, J., Knosp, M., Dascal, J., Marcia, L., Gohar, Y., Eskander, L., et al. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000198 · Cited by 498 · see citing works
Dynorphin, stress, and depression
Knoll, A. T., & Carlezon, W. A. (2010) · Brain Research · doi:10.1016/j.brainres.2009.09.074 · Cited by 465 · see citing works
Optimized Antidepressant Therapy and Pain Self-management in Primary Care Patients With Depression and Musculoskeletal Pain: A Randomized Controlled Trial
Kroenke, K., Bair, M. J., Damush, T. M., Wu, J., Hoke, S., Sutherland, J., & Tu, W. (2009) · JAMA · doi:10.1001/jama.2009.723 · Cited by 447 · see citing works
Self-citation
Longitudinal associations between depression, anxiety, pain, and pain-related disability in chronic pain patients
Lerman, S. F., Rudich, Z., Brill, S., Shalev, H., & Shahar, G. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000158 · Cited by 408 · see citing works
Obesity effects on depression: systematic review of epidemiological studies
Atlantis, E., & Baker, M. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.54 · Cited by 399 · see citing works
Mindfulness-based interventions for chronic pain: a systematic review of the evidence
Chiesa, A., & Serretti, A. (2011) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2009.0546 · Cited by 374 · see citing works
The Association of Depression and Anxiety with Pain: A Study from NESDA
de Heer, E. W., Gerrits, M. M. J. G., Beekman, A. T. F., Dekker, J., van Marwijk, H. W. J., de Waal, M. W. M., Spinhoven, P., Penninx, B. W. J. H., & van der Feltz-Cornelis, C. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106907 · Cited by 363 · see citing works
Psychological processing in chronic pain: a neural systems approach
Simons, L. E., Elman, I., & Borsook, D. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.006 · Cited by 359 · see citing works
Assessment of Psychosocial and Functional Impact of Chronic Pain
Turk, D. C., Fillingim, R. B., Ohrbach, R., & Patel, K. V. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.02.006 · Cited by 350 · see citing works
The relation between multiple pains and mental disorders: results from the World Mental Health Surveys
Gureje, O., Von Korff, M., Kola, L., Demyttenaere, K., He, Y., Posada-Villa, J., Lepine, J. P., Angermeyer, M. C., Levinson, D., de Girolamo, G., et al. (2008) · Pain · doi:10.1016/j.pain.2007.05.005 · Cited by 337 · see citing works
Collaborative Care for Chronic Pain in Primary Care: A Cluster Randomized Trial
Dobscha, S. K., Corson, K., Perrin, N. A., Hanson, G. C., Leibowitz, R. Q., Doak, M. N., Dickinson, K. C., Sullivan, M. D., & Gerrity, M. S. (2009) · JAMA · doi:10.1001/jama.2009.377 · Cited by 330 · see citing works
Stress-induced hyperalgesia
Jennings, E. M., Okine, B. N., Roche, M., & Finn, D. P. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.06.003 · Cited by 318 · see citing works
Interoceptive dysfunction: Toward an integrated framework for understanding somatic and affective disturbance in depression
Harshaw, C. (2015) · Psychological Bulletin · doi:10.1037/a0038101 · Cited by 302 · see citing works
The association of depression and anxiety with health-related quality of life in cancer patients with depression and/or pain
Brown, L. F., Kroenke, K., Theobald, D. E., Wu, J., & Tu, W. (2010) · Psycho-Oncology · doi:10.1002/pon.1627 · Cited by 295 · see citing works
Self-citation
The Patient–Provider Relationship in Chronic Pain Care: Providers' Perspectives
Matthias, M. S., Parpart, A. L., Nyland, K. A., Huffman, M. A., Stubbs, D. L., Sargent, C., & Bair, M. J. (2010) · Pain Medicine · doi:10.1111/j.1526-4637.2010.00980.x · Cited by 298 · see citing works
Self-citation
Risk factors for low back pain and sciatica: an umbrella review
Parreira, P., Maher, C. G., Steffens, D., Hancock, M. J., & Ferreira, M. L. (2018) · The Spine Journal · doi:10.1016/j.spinee.2018.05.018 · Cited by 280 · see citing works
Prescription Opioid Use among Adults with Mental Health Disorders in the United States
Davis, M. A., Lin, L. A., Liu, H., & Sites, B. D. (2017) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2017.04.170112 · Cited by 270 · see citing works
Depression in patients with chronic pain attending a specialised pain treatment centre: prevalence and impact on health care costs
Rayner, L., Hotopf, M., Petkova, H., Matcham, F., Simpson, A., & McCracken, L. M. (2016) · Pain · doi:10.1097/j.pain.0000000000000542 · Cited by 290 · see citing works
Pain and Depression: An Integrative Review of Neurobiological and Psychological Factors
Goesling, J., Clauw, D. J., & Hassett, A. L. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0421-0 · Cited by 285 · see citing works
Barriers and Facilitators to Chronic Pain Self-Management: A Qualitative Study of Primary Care Patients with Comorbid Musculoskeletal Pain and Depression
Bair, M. J., Matthias, M. S., Nyland, K. A., Huffman, M. A., Stubbs, D. L., Kroenke, K., & Damush, T. M. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00707.x · Cited by 259 · see citing works
Self-citation
Psychological therapies for the management of chronic pain
Sturgeon, J. (2014) · Psychology Research and Behavior Management · doi:10.2147/prbm.s44762 · Cited by 259 · see citing works
Understanding fibromyalgia: lessons from the broader pain research community.
Williams, D. A., & Clauw, D. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.001 · Cited by 250 · see citing works
Relationship between tinnitus severity and psychiatric disorders
Zöger, S., Svedlund, J., & Holgers, K.-M. (2006) · Psychosomatics · doi:10.1176/appi.psy.47.4.282 · Cited by 230 · see citing works
Gender differences in depression and chronic pain conditions in a national epidemiologic survey
Munce, S. E. P., & Stewart, D. E. (2007) · Psychosomatics · doi:10.1176/appi.psy.48.5.394 · Cited by 224 · see citing works
Comorbid painful physical symptoms and depression: prevalence, work loss, and help seeking
Demyttenaere, K., Bonnewyn, A., Bruffaerts, R., Brugha, T., De Graaf, R., & Alonso, J. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.01.007 · Cited by 217 · see citing works
The role of psychological interventions in the management of patients with chronic pain
Roditi, D., & Roditi (2011) · Psychology Research and Behavior Management · doi:10.2147/prbm.s15375 · Cited by 217 · see citing works
Association between anxiety, health-related quality of life and functional impairment in primary care patients with chronic pain
Kroenke, K., Outcalt, S., Krebs, E., Bair, M. J., Wu, J., Chumbler, N., & Yu, Z. (2013) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2013.03.020 · Cited by 212 · see citing works
Self-citation
Effects of mindfulness-based cognitive therapy on body awareness in patients with chronic pain and comorbid depression
de Jong, M., Lazar, S. W., Hug, K., Mehling, W. E., Hölzel, B. K., Sack, A. T., Peeters, F., Ashih, H., Mischoulon, D., & Gard, T. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00967 · Cited by 201 · see citing works
Impact of pain on the course of depressive and anxiety disorders
Gerrits, M. M. J. G., Vogelzangs, N., van Oppen, P., van Marwijk, H. W. J., van der Horst, H., & Penninx, B. W. J. H. (2012) · Pain · doi:10.1016/j.pain.2011.11.001 · Cited by 199 · see citing works
The role of depression and catastrophizing in musculoskeletal pain
Lintonl, S. J., Nicholasl, M. K., MacDonaldl, S., Boersmal, K., Bergboml, S., Maherl, C., & Refshaugel, K. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2010.08.009 · Cited by 198 · see citing works
Depression Effects on Long-term Prescription Opioid Use, Abuse, and Addiction
Sullivan, M. D. (2018) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000603 · Cited by 196 · see citing works
Chronic Pain and Cognitive Behavioral Therapy: An Integrative Review
Knoerl, R., Lavoie Smith, E. M., & Weisberg, J. (2016) · Western Journal of Nursing Research · doi:10.1177/0193945915615869 · Cited by 194 · see citing works
Better Off Dead: Suicidal Thoughts in Cancer Patients
Walker, J., Waters, R. A., Murray, G., Swanson, H., Hibberd, C. J., Rush, R. W., Storey, D. J., Strong, V. A., Fallon, M. T., Wall, L. R., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.8844 · Cited by 195 · see citing works
Operating Characteristics of PROMIS Four-Item Depression and Anxiety Scales in Primary Care Patients with Chronic Pain
Kroenke, K., Yu, Z., Wu, J., Kean, J., & Monahan, P. O. (2014) · Pain Medicine · doi:10.1111/pme.12537 · Cited by 187 · see citing works
Self-citation
The impact of major depressive disorder on the short‐ and long‐term outcome of Crohn's disease treatment with infliximab
PERSOONS, P., VERMEIRE, S., DEMYTTENAERE, K., FISCHLER, B., VANDENBERGHE, J., VAN OUDENHOVE, L., PIERIK, M., HLAVATY, T., VAN ASSCHE, G., NOMAN, M., et al. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02535.x · Cited by 253 · see citing works
The Pain Course: a randomised controlled trial of a clinician-guided Internet-delivered cognitive behaviour therapy program for managing chronic pain and emotional well-being
Dear, B. F., Titov, N., Perry, K. N., Johnston, L., Wootton, B. M., Terides, M. D., Rapee, R. M., & Hudson, J. L. (2013) · Pain · doi:10.1016/j.pain.2013.03.005 · Cited by 182 · see citing works
Longitudinal association between pain, and depression and anxiety over four years
Gerrits, M. M. J. G., van Marwijk, H. W. J., van Oppen, P., van der Horst, H., & Penninx, B. W. J. H. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.10.011 · Cited by 172 · see citing works
The impact of massage therapy on function in pain populations—A systematic review and meta-analysis of randomized controlled trials: part I, patients experiencing pain in the general population
Crawford, C., Boyd, C., Paat, C. F., Price, A., Xenakis, L., Yang, E., Zhang, W., & the Evidence for Massage Therapy (EMT) Working Group (2016) · Pain Medicine · doi:10.1093/pm/pnw099 · Cited by 178 · see citing works
Key role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain
Yang, C., Fang, X., Zhan, G., Huang, N., Li, S., Bi, J., Jiang, R., Yang, L., Miao, L., Zhu, B., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0379-8 · Cited by 176 · see citing works
Psychological Interventions for the Treatment of Chronic Pain in Adults
Driscoll, M. A., Edwards, R. R., Becker, W. C., Kaptchuk, T. J., & Kerns, R. D. (2021) · Psychological Science in the Public Interest · doi:10.1177/15291006211008157 · Cited by 176 · see citing works
Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?
Capuron, L., Fornwalt, F. B., Knight, B. T., Harvey, P. D., Ninan, P. T., & Miller, A. H. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.017 · Cited by 164 · see citing works
Psychiatric and psychological aspects in the Ehlers–Danlos syndromes
Bulbena, A., Baeza‐Velasco, C., Bulbena‐Cabré, A., Pailhez, G., Critchley, H., Chopra, P., Mallorquí‐Bagué, N., Frank, C., & Porges, S. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31544 · Cited by 149 · see citing works
Psychological factors and treatment opportunities in low back pain
Pincus, T., & McCracken, L. M. (2013) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2013.09.010 · Cited by 144 · see citing works
The outcome of physical symptoms with treatment of depression
Greco, T., Eckert, G., & Kroenke, K. (2004) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2004.30531.x · Cited by 145 · see citing works
Self-citation
Pain sensitivity in patients with major depression: differential effect of pain sensitivity measures, somatic cofactors, and disease characteristics
Hermesdorf, M., Berger, K., Baune, B. T., Wellmann, J., Ruscheweyh, R., & Wersching, H. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.01.474 · Cited by 140 · see citing works
The Interaction Between Chronic Pain and PTSD
Kind, S., & Otis, J. D. (2019) · Current Pain and Headache Reports · doi:10.1007/s11916-019-0828-3 · Cited by 146 · see citing works
Telehealth Versus In-Person Acceptance and Commitment Therapy for Chronic Pain: A Randomized Noninferiority Trial.
Herbert, M. S., Afari, N., Liu, L., Heppner, P., Rutledge, T., Williams, K., Eraly, S., VanBuskirk, K., Nguyen, C., Bondi, M., et al. (2017) · The Journal of Pain · doi:10.1016/j.jpain.2016.10.014 · Cited by 137 · see citing works
Depression-like behaviour in rats with mononeuropathy is reduced by the CB2-selective agonist GW405833
Hu, B., Doods, H., Treede, R.-D., & Ceci, A. (2009) · Pain · doi:10.1016/j.pain.2009.02.018 · Cited by 138 · see citing works
Physical Exercise for Treatment of Mood Disorders: A Critical Review
Hearing, C. M., Chang, W. C., Szuhany, K. L., Deckersbach, T., Nierenberg, A. A., & Sylvia, L. G. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0089-y · Cited by 137 · see citing works
Psychiatric disorders as assessed with SCID in chronic pain patients: the anxiety disorders precede the onset of pain
Knaster, P., Karlsson, H., Estlander, A.-M., & Kalso, E. (2012) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2011.09.004 · Cited by 136 · see citing works
Psychology of Chronic Pelvic Pain: Prevalence, Neurobiological Vulnerabilities, and Treatment
TILL, S. R., AS-SANIE, S., & SCHREPF, A. (2019) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000412 · Cited by 134 · see citing works
Physical activity and depression: a large cross‐sectional, population‐based study across 36 low‐ and middle‐income countries
Stubbs, B., Koyanagi, A., Schuch, F. B., Firth, J., Rosenbaum, S., Veronese, N., Solmi, M., Mugisha, J., & Vancampfort, D. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12654 · Cited by 128 · see citing works
The prevalence of pain in bipolar disorder: a systematic review and large-scale meta-analysis
Stubbs, B., Eggermont, L., Mitchell, A. J., De Hert, M., Correll, C. U., Soundy, A., Rosenbaum, S., & Vancampfort, D. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12325 · Cited by 129 · see citing works
Comorbidity between pain and mental illness—evidence of a bidirectional relationship
Bondesson, E., Larrosa Pardo, F., Stigmar, K., Ringqvist, Å., Petersson, I. F., Jöud, A., & Schelin, M. E. C. (2018) · European Journal of Pain · doi:10.1002/ejp.1218 · Cited by 131 · see citing works
Origins and outlook of interoceptive exposure
Boettcher, H., Brake, C. A., & Barlow, D. H. (2016) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2015.10.009 · Cited by 124 · see citing works
Evaluating distance education of a mindfulness-based meditation programme for chronic pain management
Gardner-Nix, J., Backman, S., Barbati, J., & Grummitt, J. (2008) · Journal of Telemedicine and Telecare · doi:10.1258/jtt.2007.070811 · Cited by 124 · see citing works
Efficacy of a transdiagnostic emotion-focused exposure treatment for chronic pain patients with comorbid anxiety and depression: a randomized controlled trial
Boersma, K., Södermark, M., Hesser, H., Flink, I. K., Gerdle, B., & Linton, S. J. (2019) · Pain · doi:10.1097/j.pain.0000000000001575 · Cited by 123 · see citing works
School Functioning in Adolescents With Chronic Pain: The Role of Depressive Symptoms in School Impairment
Logan, D. E., Simons, L. E., & Kaczynski, K. J. (2009) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsn143 · Cited by 123 · see citing works
Customizing Treatment of Chronic Fatigue Syndrome and Fibromyalgia: The Role of Perpetuating Factors
Houdenhove, B. V., & Luyten, P. (2008) · Psychosomatics · doi:10.1176/appi.psy.49.6.470 · Cited by 122 · see citing works
Opioid analgesics
Jamison, R. N., & Mao, J. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.04.010 · Cited by 117 · see citing works
Pain, not chronic disease, is associated with the recurrence of depressive and anxiety disorders
Gerrits, M. M., van Oppen, P., Leone, S. S., van Marwijk, H. W., van der Horst, H. E., & Penninx, B. W. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-187 · Cited by 106 · see citing works
Chronic low back pain and the risk of depression or anxiety symptoms: insights from a longitudinal twin study
Fernandez, M., Colodro-Conde, L., Hartvigsen, J., Ferreira, M. L., Refshauge, K. M., Pinheiro, M. B., Ordoñana, J. R., & Ferreira, P. H. (2017) · The Spine Journal · doi:10.1016/j.spinee.2017.02.009 · Cited by 115 · see citing works
Drug Overdose in a Retrospective Cohort with Non-Cancer Pain Treated with Opioids, Antidepressants, and/or Sedative-Hypnotics: Interactions with Mental Health Disorders
Turner, B. J., & Liang, Y. (2015) · Journal of General Internal Medicine · doi:10.1007/s11606-015-3199-4 · Cited by 109 · see citing works
Depression and anxiety in patients with different rare chronic diseases: A cross-sectional study.
Uhlenbusch, N., Löwe, B., Härter, M., Schramm, C., Weiler-Normann, C., & Depping, M. K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211343 · Cited by 111 · see citing works
Digital Care for Chronic Musculoskeletal Pain: 10,000 Participant Longitudinal Cohort Study
Bailey, J. F., Agarwal, V., Zheng, P., Smuck, M., Fredericson, M., Kennedy, D. J., & Krauss, J. (2020) · Journal of Medical Internet Research · doi:10.2196/18250 · Cited by 109 · see citing works
An interdisciplinary pain rehabilitation program for veterans with chronic pain: description and initial evaluation of outcomes
Anamkath, N. S., Palyo, S. A., Jacobs, S. C., Lartigue, A., Schopmeyer, K., & Strigo, I. A. (2018) · Pain Research and Management · doi:10.1155/2018/3941682 · Cited by 103 · see citing works
Depression and pain: primary data and meta-analysis among 237,952 people across 47 low- and middle-income countries
Stubbs, B., Vancampfort, D., Veronese, N., Thompson, T., Fornaro, M., Schofield, P., Solmi, M., Mugisha, J., Carvalho, A. F., & Koyanagi, A. (2017) · Psychological Medicine · doi:10.1017/s0033291717001477 · Cited by 102 · see citing works
Comparing the Effectiveness of Mindfulness-based Stress Reduction and Multidisciplinary Intervention Programs for Chronic Pain: A Randomized Comparative Trial
Wong, S. Y.-S., Chan, F. W.-K., Wong, R. L.-P., Chu, M.-C., Kitty Lam, Y.-Y., Mercer, S. W., & Ma, S. H. (2011) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e3182183c6e · Cited by 100 · see citing works
Chronic pain, craving, and illicit opioid use among patients receiving opioid agonist therapy
Tsui, J. I., Lira, M. C., Cheng, D. M., Winter, M. R., Alford, D. P., Liebschutz, J. M., Edwards, R. R., & Samet, J. H. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.06.024 · Cited by 97 · see citing works
Beneficial Effects of Improvement in Depression, Pain Catastrophizing, and Anxiety on Pain Outcomes: A 12-Month Longitudinal Analysis
Scott, E. L., Kroenke, K., Wu, J., & Yu, Z. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2015.10.011 · Cited by 98 · see citing works
Self-citation
Providers’ roles in enhancing patients’ adherence to pain self management
Dorflinger, L., Kerns, R. D., & Auerbach, S. M. (2013) · Translational Behavioral Medicine · doi:10.1007/s13142-012-0158-z · Cited by 97 · see citing works
Interleukin-10: A Key Cytokine in Depression?
Roque, S., Correia-Neves, M., Mesquita, A. R., Palha, J. A., & Sousa, N. (2009) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2009/187894 · Cited by 89 · see citing works
Role of common mental and physical disorders in partial disability around the world
Bruffaerts, R., Vilagut, G., Demyttenaere, K., Alonso, J., AlHamzawi, A., Andrade, L. H., Benjet, C., Bromet, E., Bunting, B., de Girolamo, G., et al. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.097519 · Cited by 96 · see citing works
Associations between chronic pain, anxiety, and depression among adults in the United States
Mullins, P. M., Yong, R. J., & Bhattacharyya, N. (2023) · Pain Practice · doi:10.1111/papr.13220 · Cited by 98 · see citing works
Gratitude uniquely predicts lower depression in chronic illness populations: A longitudinal study of inflammatory bowel disease and arthritis.
Sirois, F. M., & Wood, A. M. (2017) · Health Psychology · doi:10.1037/hea0000436 · Cited by 93 · see citing works
PAIN AND DEPRESSION: THE EGG AND THE CHICKEN STORY REVISITED
Gambassi, G. (2009) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2009.09.018 · Cited by 93 · see citing works
Health Coaching via an Internet Portal for Primary Care Patients With Chronic Conditions: A Randomized Controlled Trial
Leveille, S. G., Huang, A., Tsai, S. B., Allen, M., Weingart, S. N., & Iezzoni, L. I. (2009) · Medical Care · doi:10.1097/mlr.0b013e3181844dd0 · Cited by 89 · see citing works
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids
Leitl, M. D., Onvani, S., Bowers, M. S., Cheng, K., Rice, K. C., Carlezon, W. A., Banks, M. L., & Negus, S. S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.236 · Cited by 87 · see citing works
Empowering Patients with Persistent Pain Using an Internet-based Self-Management Program
Wilson, M., Roll, J. M., Corbett, C., & Barbosa-Leiker, C. (2015) · Pain Management Nursing · doi:10.1016/j.pmn.2014.09.009 · Cited by 83 · see citing works

Elderly patients with head and neck cancer: the influence of comorbidity on choice of therapy, complication rate, and survival
Derks, W., de Leeuw, R. J., & Hordijk, G. J. (2005) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/01.moo.0000156169.63204.39 · Cited by 66 · see citing works
Influence of comorbidity on the choice of treatment and survival of elderly patients with advanced non-small cell lung cancer
Ai-wu, Li, Caicun, et al. (2008) · Acta Scientiarum Naturalium Universitatis Sunyatseni
Health Care Resource Utilization And Costs Associated With HIV-Positive Patients With Comorbidity Versus HIV-Negative Patients With Comorbidity
Lachaîne, J., Baribeau, V., Lorgeoux, R.-P., et al. (2017) · Value in Health · doi:10.1016/j.jval.2017.08.2323 · Cited by 4 · see citing works
Comorbidity in head and neck cancer: A critical appraisal and recommendations for practice
Paleri, V., Wight, R. G., Silver, C. E., Haigentz, M., Takes, R. P., Bradley, P. J., Rinaldo, A., Sanabria, Á., Bień, S., & Ferlito, A. (2010) · Oral Oncology · doi:10.1016/j.oraloncology.2010.07.008 · Cited by 247 · see citing works
Assessing the impact of comorbidity in the older population
Guralnik, J. M. (1996) · Annals of Epidemiology · doi:10.1016/s1047-2797(96)00060-9 · Cited by 224 · see citing works

Authors: Bair, M. J., Robinson, R. L., Katon, W., & Kroenke, K.
Affiliations: Indiana University Indianapolis (US)
Corresponding author: Bair, Matthew J.
ORCID: Bair, Matthew J.
Robinson, Rebecca L.
Kroenke, Kurt
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2003-11-10
Volume: 163
Issue: 20
Pages: 2433
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.163.20.2433
OpenAlex: W2148694444
Cited by: 3,463
References: 178
Citations by year: 2026: 191 · 2025: 202 · 2024: 208 · 2023: 206 · 2022: 189 · 2021: 219 · 2020: 216 · 2019: 197 · 2018: 176 · 2017: 178 · 2016: 161 · 2015: 168 · 2014: 171 · 2013: 169 · 2012: 154
FWCI: 3.73
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Bristol-Myers Squibb
Eli Lilly and Company
Pfizer
GlaxoSmithKline
University of Washington
School of Medicine, Indiana University
Topics: Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: depression, chronic pain, comorbidities, prevalence, diagnosis, clinical outcomes, quality of life, work impairment, health care utilization, refractory pain, neurotransmitters
MeSH terms: Antidepressive Agents, Chronic Disease, Depression, Depressive Disorder, Humans, Pain, Comorbidity, Prevalence, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Depression and Pain Comorbidity: A Literature Review

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks