The DOI matches its Crossref record; 228 of the 228 references it cites were found in a registry or an index.
The theory of bipolar disorder as an illness of accelerated aging: Implications for clinical care and research
Abstract
Bipolar Disorder (BD) has been conceptualized as both a cyclic and a progressive disorder. Mechanisms involved in neuroprogression in BD remain largely unknown although several non-mutually exclusive models have been proposed as explanatory frameworks. In the present paper, we propose that the pathophysiological changes observed in BD (e.g. brain structural alterations, cognitive deficits, oxidative stress imbalance, amyloid metabolism, immunological deregulation, immunosenescence, neurotrophic deficiencies and telomere shortening) converge on a model of accelerated aging (AA). Aging can be understood as a multidimensional process involving physical, neuropsychological, and social changes, which can be highly variable between individuals. Determinants of successful aging (e.g environmental and genetic factors), may also confer differential vulnerability to components of BD pathophysiology and contribute to the clinical presentation of BD. Herein we discuss how the understanding of aging and senescence can contribute to the search for new and promising molecular targets to explain and ameliorate neuroprogression in BD. We also present the strengths and limitations of this concept.
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“Bipolar disorder (BD) may also be characterized by “accelerated aging” (Rizzo et al., 2014; Sodhi et al., 2012; Yatham et al., 2009 (but see Gildengers et al., 2013)).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Rizzo et al., 2014
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Metadata
- Authors
- Rizzo, L. B., Costa, L. G., Mansur, R. B., Swardfager, W., Belangero, S. I., Grassi-Oliveira, R., McIntyre, R. S., Bauer, M. E., & Brietzke, E.
- Affiliations
- Universidade Federal de São Paulo (BR)
- University Health Network (CA)
- University of Toronto (CA)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- Corresponding author
- Brietzke, Elisa
- ORCID
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 42
- Pages
- 157-169
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2031122384
- Cited by
- 183
- References
- 228
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 14 · 2023: 12 · 2022: 22 · 2021: 6 · 2020: 23 · 2019: 16 · 2018: 14 · 2017: 15 · 2016: 17 · 2015: 18 · 2014: 5
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Toronto Rehabilitation Institute
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, accelerated aging, neuroprogression, immunosenescence, telomere shortening, oxidative stress, amyloid metabolism, brain structural changes, cognitive impairment, successful aging, molecular targets
- MeSH terms
- Animals, Bipolar Disorder, Brain, Humans, Models, Neurological, Aging, Premature
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