Cerebellar telomere length and psychiatric disorders
Open accessAbstract
We tested whether telomere length is altered in the brains of patients diagnosed with major depression (MD), bipolar disorder (BD) and schizophrenia (SZ) by measuring mean telomere length (mTL) with real-time PCR. The samples are cerebellar gray matter from 46 SZ, 46 BP, and 15 MD patients, and 48 healthy controls. We found no difference in mTL between SZ and controls, BD and controls, MD and controls, or all cases and controls; no correlation between mTL and age was observed, either. This suggests that brain gray matter is unlikely to be related to the telomere length shortening reported in blood of psychiatric patients. White matter deserves further investigation as it has been reported to have a different mTL dynamic from gray matter. Since mTL has been reported to be a heritable quantitative trait, we also carried out genome-wide mapping of genetic factors for mTL, treating mTL as a quantitative trait. No association survived correction of multiple testing for the number of SNPs studied. The previously reported rs2630578 (BICD1) association was not replicated. This suggests that telomere length of cerebellar gray matter is determined by multiple loci with "weak effects."
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Two post-mortem studies of TL in cerebellar gray matter and occipital cortex found no significant differences between MDD subjects and controls, although correlations with LTL were not assessed.
“Two post-mortem studies of TL in cerebellar gray matter and occipital cortex found no significant differences between MDD subjects and controls, although correlations with LTL were not assessed (Teyssier et al., 2010; Zhang et al., 2010).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Zhang et al., 2010
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BackgroundThe role of the cerebellum in schizophrenia
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“A significant difference in mTL (measured by Southern blot) was also reported in a lymphocyte study of 44 combined mood disorders (15 MD and 15 BD with anxiety and 14 BD without anxiety) and 44 controls (p-value = 0.002) ( Simon et al. 2006 ).”
BackgroundInfluentialThe cognitive neuroscience of schizophrenia.
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Maletic, V., Robinson, M., Oakes, T. M. M., Iyengar, S., Ball, S. G., & Russell, J. D. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01602.x · Cited by 387 · cited 1× · see citing works
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BackgroundTelomere Length Inversely Correlates With Pulse Pressure and Is Highly Familial
Jeanclos, E. M., Schork, N. J., Kyvik, K. O., Kimura, M., Skurnick, J., & Aviv, A. (2000) · Hypertension · doi:10.1161/01.hyp.36.2.195 · Cited by 352 · cited 2× · see citing works
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BackgroundRegulation of Murine Telomere Length by Rtel
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Mapping of a Major Locus that Determines Telomere Length in Humans
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“The mTL of most somatic cells is negatively correlated with age, although it varies greatly among individuals, even those in the same age group (Andrew et al. 2006; Okuda et al. 2000; Vasa-Nicotera et al. 2005; Vaziri et al. 1994; Vaziri et al. 1993).”
BackgroundAndrew, T., Aviv, A., Falchi, M., Surdulescu, G. L., Gardner, J. P., Lu, X., Kimura, M., Kato, B. S., Valdes, A. M., & Spector, T. D. (2006) · The American Journal of Human Genetics · doi:10.1086/500052 · Cited by 252 · cited 4× · see citing works
“The mTL of most somatic cells is negatively correlated with age, although it varies greatly among individuals, even those in the same age group (Andrew et al. 2006; Okuda et al. 2000; Vasa-Nicotera et al. 2005; Vaziri et al. 1994; Vaziri et al. 1993).”
BackgroundInfluentialThomas, P., Callaghan, N. J. O., & Fenech, M. F. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.12.004 · Cited by 249 · cited 2× · see citing works
“observed a significant age effect on mTL in white blood cells but not in buccal cells (Thomas et al. 2008).”
BackgroundIs the cerebellum relevant in the circuitry of neuropsychiatric disorders?
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“…and Behavioral Neuroscience, The University of Chicago, Chicago, IL 60637, USA e-mail: cliu@yoda.bsd.uchicago.edu D. W. Craig M. Redman The Translational Genomic Research Institute, Phoenix, AZ 85004, USA BD, SZ, and MD (Andreasen and Pierson 2008; Konarski et al. 2005; Schmahmann et al. 2007).”
BackgroundTelomere attrition of the human abdominal aorta: relationships with age and atherosclerosis
Okuda, K., Khan, M. Y., Skurnick, J., Kimura, M., Aviv, H., & Aviv, A. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00482-7 · Cited by 217 · cited 1× · see citing works
“The mTL of most somatic cells is negatively correlated with age, although it varies greatly among individuals, even those in the same age group (Andrew et al. 2006; Okuda et al. 2000; Vasa-Nicotera et al. 2005; Vaziri et al. 1994; Vaziri et al. 1993).”
BackgroundEvidence that oxidative stress is linked to anxiety-related behaviour in mice
Rammal, H., Bouayed, J., Younos, C., & Soulimani, R. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.06.005 · Cited by 204 · cited 2× · see citing works
“The facts that oxidative status in the cerebellum, cerebral cortex, hippocampus, and peripheral leucocytes is associated with anxiety levels in mice (Rammal et al. 2008), and that oxidative status is also thought to be related to telomere length (von Zglinicki 2002), support a prediction that…”
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“Data from yeast suggest that telomere length variation is associated with polymorphisms at a large number of loci (Gatbonton et al. 2006).”
BackgroundResultThe Psychopathology and Treatment of Bipolar Disorder
Miklowitz, D. J., & Johnson, S. L. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.2.022305.095332 · Cited by 183 · cited 1× · see citing works
“Prefrontal and limbic system dysfunction are known to be strongly involved in the development of SZ, BD, and MD (Barch 2005; Maletic et al. 2007; McIntosh et al. 2008; Miklowitz and Johnson 2006).”
BackgroundRapid telomere erosion in schizophrenia
Kao, H.-T., Cawthon, R. M., DeLisi, L. E., Bertisch, H. C., Ji, F., Gordon, D., Li, P., Benedict, M. M., Greenberg, W. M., & Porton, B. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002105 · Cited by 128 · cited 6× · see citing works
“The SD in our samples was comparable to control group A in the study by Kao et al. (2008), despite the difference in mean (control group A, 1.51 ± 0.33; control group B, 1.51 ± 0.62).”
BackgroundResultInfluentialGenetic pathway of major depressive disorder in shortening telomeric length
Lung, F., Chen, N. C., & Shu, B. (2007) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32808374f6 · Cited by 118 · cited 3× · see citing works
“Decreased telomere length in MD (measured by Southern blot) has been reported in white blood cells when comparing 253 patients to 411 controls (Lung et al. 2007) (age MD = 44.”
BackgroundInfluentialPrefrontal Function and Activation in Bipolar Disorder and Schizophrenia
McIntosh, A. M., Whalley, H. C., McKirdy, J. W., Hall, J., Sussmann, J. E., Shankar, P., Johnstone, E. C., & Lawrie, S. M. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07020365 · Cited by 116 · cited 1× · see citing works
“Prefrontal and limbic system dysfunction are known to be strongly involved in the development of SZ, BD, and MD (Barch 2005; Maletic et al. 2007; McIntosh et al. 2008; Miklowitz and Johnson 2006).”
BackgroundTelomeres, stem cells, and hematology
Lansdorp, P. M. (2008) · Blood · doi:10.1182/blood-2007-09-084913 · Cited by 93 · cited 1× · see citing works
“Telomeres comprise a variable number of repeats of the sequence TTAGGG (Blackburn 1991; Zakian 1995) and their lengths decline with cell division (Lansdorp 2008).”
BackgroundA regulatory SNP of the BICD1 gene contributes to telomere length variation in humans
Mangino, M., Brouilette, S., Braund, P. S., Tirmizi, N., Vasa‐Nicotera, M., Thompson, J. R., & Samani, N. J. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn152 · Cited by 65 · cited 2× · see citing works
“SNP rs2630578 in BICD1 was previously reported to be associated with telomere length in leukocytes (Mangino et al. 2008).”
BackgroundNakamura, K., Takubo, K., Izumiyama‐Shimomura, N., Sawabe, M., Arai, T., Kishimoto, H., Fujiwara, M., Kato, M., Oshimura, M., Ishii, A., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.003 · Cited by 63 · cited 1× · see citing works
“However, Nakamura and colleagues found that telomeres in the cerebral gray matter were longer than those in the cerebral white matter, and observed no difference in telomere length between infants and individuals aged 60–69 years (Nakamura et al. 2007).”
BackgroundWang, J. C. Y., Warner, J. K., Erdmann, N., Lansdorp, P. M., Harrington, L. A., & Dick, J. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504161102 · Cited by 56 · cited 2× · see citing works
“Also, telomere length has been shown to vary among tissues (Prowse and Greider 1995; Wang et al. 2005).”
BackgroundAlaerts, M., & Del‐Favero, J. (2009) · Human Mutation · doi:10.1002/humu.21042 · Cited by 56 · cited 2× · see citing works
“Genetics of telomere length BD, SZ, and MD all have underlying genetic factors (Alaerts and Del-Favero 2009; Shyn et al. 2009).”
BackgroundZhang, F., Kato, B. S., Gardner, J. P., Kimura, M., Spector, T. D., & Ahmadi, K. R. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.05.007 · Cited by 8 · cited 2× · see citing works
“In humans, although a genetic association mapping study of two candidate genes failed to generate a positive result (Zhang et al. 2007), linkage”
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Telomeres and early-life stress: an overview
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“Two studies on depression and TL in the occipital cortex (57) and cerrebellar gray matter (58) failed to find an association.”
BackgroundDepression and telomere length: a meta-analysis
Ridout, K. K., Ridout, S. J., Price, L. H., Sen, S., & Tyrka, A. R. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.052 · Cited by 258 · see citing works
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“A recent study determined telomere length in the gray matter of the cerebellum from patients with psychiatric disorders and found no shortened telomere length in the brain of the patients.([24]) Furthermore, telomere length in the brain was not shortened with age, which is most likely due to the low rate of cell divis…”
BackgroundMolecular biomarkers of depression
Gururajan, A., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.011 · Cited by 134 · see citing works
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Neurophysiological and epigenetic effects of physical exercise on the aging process
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Mamdani, F., Rollins, B. L., Morgan, L. Z., Myers, R., Barchas, J. D., Schatzberg, A. F., Watson, S. J., Akil, H., Potkin, S. G., Bunney, W. E., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.134 · Cited by 92 · see citing works
Maes, M. H. J., Kubera, M., Mihaylova, I., Geffard, M., Gałecki, P., Leunis, J.-C., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.039 · Cited by 87 · see citing works
Accelerated hippocampal biological aging in bipolar disorder
Fries, G. R., Bauer, I. E., Scaini, G., Valvassori, S. S., Walss‐Bass, C., Soares, J. C., & Quevedo, J. (2019) · Bipolar Disorders · doi:10.1111/bdi.12876 · Cited by 85 · see citing works
Strategies for Successful Aging: A Research Update
Harmell, A. L., Jeste, D. V., & Depp, C. A. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0476-6 · Cited by 79 · see citing works
“For example, Erickson et al. (2011) 14 compared sedentary nondemented older adults participating in a walking program with a group who did only stretching exercises.”
Telomerase Dysregulation in the Hippocampus of a Rat Model of Depression: Normalization by Lithium
Wei, Y. B., Backlund, L., Wegener, G., Mathé, A. A., & Lavebratt, C. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv002 · Cited by 81 · see citing works
“Two studies (Teyssier et al., 2010; Zhang et al., 2010) reported normal TL in occipital cortex and cerebellum, respectively, of postmortem brains from major depression patients.”
BackgroundMamdani, F., Rollins, B. L., Morgan, L. Z., Myers, R., Barchas, J. D., Schatzberg, A. F., Watson, S. J., Akil, H., Potkin, S. G., Bunney, W. E., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.164 · Cited by 76 · see citing works
Huang, Y., Wang, L., Tseng, P., Hung, C., & Lin, P. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.09.035 · Cited by 73 · see citing works
Leukocyte telomere length in patients with schizophrenia: A meta-analysis
Polho, G. B., de Paula, V. D. J. R., Cardillo, G. D. M., dos Santos, B., & Kerr, D. S. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.04.025 · Cited by 73 · see citing works
“Mansour et al. (2011) and Zhang et al. (2010) found no difference between patients and control.”
BackgroundMansour, H., Chowdari, K., Fathi, W., Elassy, M., Ibrahim, I., Wood, J., Bamne, M., Tobar, S., Yassin, A., Salah, H., et al. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2011.01.010 · Cited by 58 · see citing works
“1) (Zhang et al., 2010).”
Mood Disorders, Accelerated Aging, and Inflammation: Is the Link Hidden in Telomeres?
Squassina, A., Pisanu, C., & Vanni, R. (2019) · Cells · doi:10.3390/cells8010052 · Cited by 54 · see citing works
“However, findings from these studies so far do not support an association between BD and TL in cerebellar gray matter [60], or in different brain regions, including the dorsolateral prefrontal cortex, hippocampus, amygdala, nucleus accumbens, and substantia nigra [61].”
ResultIs bipolar disorder associated with accelerating aging? A meta-analysis of telomere length studies
Colpo, G. D., Leffa, D. D., Köhler, C. A., Kapczinski, F. P., Quevedo, J., & Carvalho, A. F. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.034 · Cited by 53 · see citing works
“Similarly, telomere lengths did not differ in the cerebellar gray matter of individuals with BD compared to controls (Zhang et al., 2010).”
BackgroundTelomeres, Early-Life Stress and Mental Illness
Ridout, S. J., Ridout, K. K., Kao, H., Carpenter, L. L., Philip, N. S., Tyrka, A. R., & Price, L. H. (2015) · Advances in psychosomatic medicine · doi:10.1159/000369088 · Cited by 47 · see citing works
No Evidence for Shorter Leukocyte Telomere Length in Parkinson's Disease Patients
Eerola, J., Kananen, L., Manninen, K., Hellström, O., Tienari, P. J., & Hovatta, I. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq125 · Cited by 47 · see citing works
Telomere length in bipolar disorder and lithium response
Squassina, A., Pisanu, C., Corbett, N., & Alda, M. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.10.008 · Cited by 43 · see citing works
Major depressive disorder mediates accelerated aging in rats subjected to chronic mild stress
Xie, X., Chen, Y., Ma, L., Shen, Q., Huang, L., Zhao, B., Wu, T., & Fu, Z. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.022 · Cited by 42 · see citing works
Chandley, M., Szebeni, A., Szebeni, K., Wang‐Heaton, H., Garst, J., Stockmeier, C. A., Lewis, N. H., & Ordway, G. A. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110559 · Cited by 38 · see citing works
Wium‐Andersen, M. K., Ørsted, D. D., Rode, L., Bojesen, S. E., & Nordestgaard, B. G. (2016) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.115.178798 · Cited by 38 · see citing works
Telomere length in psychiatric disorders: Is it more than an ageing marker?
Monroy‐Jaramillo, N., Dyukova, E., & Walss‐Bass, C. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1273550 · Cited by 37 · see citing works
“Similarly, TL did not differ in the cerebellar grey matter of individuals with BD compared to controls (Zhang et al. 2010).”
BackgroundPotential roles of telomeres and telomerase in neurodegenerative diseases
Wang, J., Liu, Y., Xia, Q., Xia, Q., Wang, B., Yang, C., Liang, J., & Liu, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.046 · Cited by 34 · see citing works
Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature
Muneer, A., & Minhas, F. A. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.3.343 · Cited by 31 · see citing works
Kurth, F., Cherbuin, N., & Luders, E. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00860 · Cited by 32 · see citing works
“It should also be noted that while the critical role of telomere attrition is well-established in cell aging, its specific effect on the brain is not entirely clear (Allsopp et al., 1995; Nakamura et al., 2007; Zhang et al., 2010; Eitan et al., 2014).”
BackgroundShorter leukocyte telomere length in patients at ultra high risk for psychosis
Maurya, P. K., Rizzo, L. B., Xavier, G., Tempaku, P. F., Zeni‐Graiff, M., Santoro, M. L., Mazzotti, D. R., Zugman, A., Pan, P. M., Noto, C. D. S., et al. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.02.008 · Cited by 29 · see citing works
“However, there are conflicting reports, with separate studies reporting no differences in TL in cerebellum (Malaspina et al., 2014; Zhang et al., 2010), and the largest study to date actually documenting longer telomeres in this population (Nieratschker et al.”
Rackley, S. J., Pao, M., Seratti, G. F., Giri, N., Rasimas, J. J., Alter, B. P., & Savage, S. A. (2012) · Psychosomatics · doi:10.1016/j.psym.2011.09.003 · Cited by 29 · see citing works
In vivo biomarkers of structural and functional brain development and aging in humans
Franke, K., Bublak, P., Hoyer, D., Billiet, T., Christian Gaser, B., Witte, O. W., & Schwab, M. G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.002 · Cited by 28 · see citing works
Pawełczyk, T., Szymańska, B., Grancow-Grabka, M., Kotlicka‐Antczak, M., & Pawełczyk, A. M. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s82468 · Cited by 27 · see citing works
Schiavone, S., Tucci, P., Trabace, L., & Morgese, M. G. (2019) · Molecules · doi:10.3390/molecules24213993 · Cited by 20 · see citing works
“In good agreement with our observations, previous works have reported increased direct and indirect biomarkers of oxidative stress in the cerebellum of animal models of neuropsychiatric disorders [85,86].”
ResultRyan, K. M., & McLoughlin, D. M. (2019) · Psychological Medicine · doi:10.1017/s0033291719002228 · Cited by 18 · see citing works
“, 2016) and no difference in TL (Zhang et al., 2010; Wolkowitz et al., 2011; Teyssier et al., 2012; Hoen et al., 2013; Schaakxs et al., 2015) between clinically diagnosed patients with depression and controls.”
BackgroundAging biological markers in a cohort of antipsychotic-naïve first-episode psychosis patients
Talarico, F., Xavier, G., Ota, V., Spíndola, L., Maurya, P. K., Tempaku, P. F., Moretti, P. N. S., Gadelha, A., Noto, M. N., Noto, C. D. S., et al. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105350 · Cited by 16 · see citing works
Longer Telomere Length of T lymphocytes in Patients with Early and Chronic Psychosis
Cui, Y., Prabhu, V. V., Nguyen, T. B., Devi, S. M., & Chung, Y. (2017) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2017.15.2.146 · Cited by 16 · see citing works
Transcriptomic reprogramming for neuronal age reversal
Pleşa, A. M., Shadpour, M., Boyden, E. S., & Church, G. M. (2023) · Human Genetics · doi:10.1007/s00439-023-02529-1 · Cited by 12 · see citing works
Is Telomere Length a Biomarker of Neurological Disorders?
Thanseem, I., Viswambharan, V., Poovathinal, S. A., & Anitha, A. (2017) · Biomarkers in Medicine · doi:10.2217/bmm-2017-0032 · Cited by 13 · see citing works
The Role of Glia Telomere Dysfunction in the Pathogenesis of Central Nervous System Diseases
Papageorgakopoulou, M. A., Bania, A., Lagogianni, I.-A., Birmpas, K., & Assimakopoulou, M. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03947-6 · Cited by 11 · see citing works
“…of telomere length in the cerebellar gray matter derived from patients with MDD, bipolar disorder (BD), and schizophrenia, (SZ) compared to controls, was found; the telomere length has been detected as significantly shorter in MDD than in BD, SZ, and controls, in a study of Zhang et al. [126].”
BackgroundSchröder, J. D., de Araújo, J. B., de Oliveira, T., de Moura, A. B., Fries, G. R., Quevedo, J., Réus, G. Z., & Ignácio, Z. M. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0070 · Cited by 11 · see citing works
“…et al. (2014), in addition to a meta-analysis carried out by Lin et al. (2016), bring evidence of a significant shortening of telomeres in MDD patients, while other studies, such as that of Zhang et al. (2010) and Rius-Ottenheim et al. (2012), showed no association between MDD and telomere length.”
ResultTelomere quantification in frontal and temporal brain tissue of patients with schizophrenia
van Mierlo, H. C., Wichers, C. G. K., He, Y., Sneeboer, M. A. M., Radstake, T. R. D. J., Kahn, R. S., Broen, J. C. A., & de Witte, L. D. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.09.006 · Cited by 9 · see citing works
Kłoda, K., Domański, L., Kwiatkowska, E., Borowiecka, E., Safranow, K., Drozd, A., Ciechanowicz, A., Maciejewska, A., Sawczuk, M., Pawlik, A., et al. (2015) · Kidney & Blood Pressure Research · doi:10.1159/000368487 · Cited by 7 · see citing works
Molecular biomarkers in depression: Toward personalized psychiatric treatment
Gururajan, A., Cryan, J. F., & Dinan, T. G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813176-3.00026-2 · Cited by 5 · see citing works
Telomere Length as a Marker of Suicidal Risk in Schizophrenia
Zakharova, N. V., Bravve, L. V., Mamedova, G., Kaydan, M. A., Ershova, E. S., Мартынов, А. В., Veiko, N. N., & Kostyuk, S. V. (2022) · Consortium Psychiatricum · doi:10.17816/cp171 · Cited by 3 · see citing works
Ismail, A., Jaalouk, K., Kotaich, J., Tarhini, Y., Sadier, N. S., & Abbas, L. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-07076-5 · Cited by 3 · see citing works
Interventions Addressing the Telomere-Telomerase System
Muneer, A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9721-0_26 · Cited by 3 · see citing works
Kłoda, K., Domański, L., Kwiatkowska, E., Safranow, K., Drozd, A., Ciechanowicz, A., & Ciechanowski, K. (2016) · Transplantation Proceedings · doi:10.1016/j.transproceed.2015.10.086 · Cited by 3 · see citing works
Is Depression Associated With Accelerated Aging? Mechanisms and Implications
Lindqvist, D., Simon, N. M., & Wolkowitz, O. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00019-6 · Cited by 2 · see citing works
Molecular and Cellular Evidence for Age by Disease Interactions: Updates and Path Forward
Shukla, R., Oh, H., & Sibille, E. L. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.06.001 · Cited by 2 · see citing works
Mechanisms of aging in bipolar disorder
Diniz, B. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821398-8.00011-4 · Cited by 1 · see citing works
Nowak, D. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_21
Investigação do comprimento telomérico em famílias com vários afetados pelo transtorno bipolar
Martinez, D. S. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2018.tde-06042018-121637
Precision medicine and schizophrenia: What about telomere length?
Cotta, P. A. G. D. V. R. (2019) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/m7z4-2a23
Fletcher, B. C., Hughes-Waldon, G., Marks, E. J., Waldie, K. E., Snell, R. G., Thayer, Z. M., Morton, S., Knowles, S., Ly, K. N., & Walker, C. G. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120600
Telomere length in bipolar disorder: An updated meta-analysis of observational studies
Hung, T.-H., Chen, I.-L., Huang, Y.-C., & Lin, P. (2026) · Psychiatry Research · doi:10.1016/j.psychres.2026.117092
- Authors
- Zhang, D., Cheng, L., Craig, D. W., Redman, M., & Liu, C.
- Affiliations
- University of Chicago (US)
- Translational Genomics Research Institute (US)
- Corresponding author
- Liu, Chunyu
- Venue
- Behavior Genetics
- Published
- 2010-02-03
- Volume
- 40
- Issue
- 2
- Pages
- 250-254
- ISSN
- 0001-8244 (ISSN-L)
- 1573-3297
- PMC
- PMC3053383
- OpenAlex
- W2098238271
- Cited by
- 60
- References
- 37
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 10 · 2018: 2 · 2017: 7 · 2016: 5 · 2015: 10 · 2014: 6 · 2013: 1 · 2012: 3
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Behavior Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Foundation for the National Institutes of Health
- Brain Research Foundation
- National Institute of Mental Health (R01MH080425, MH080425)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- telomere length, cerebellar gray matter, major depressive disorder, bipolar disorder, schizophrenia, mental illness, brain aging, genome-wide association study, genetic loci, white matter
- MeSH terms
- Adult, Age Factors, Aged, Mental Disorders, Brain, Cerebellum, Female, Genotype, Humans, Male, Middle Aged, Case-Control Studies, Telomere, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Genome-Wide Association Study
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