The DOI matches its Crossref record; 175 of the 177 references it cites were found in a registry or an index.
Cognition-related brain networks underpin the symptoms of unipolar depression: Evidence from a systematic review
Abstract
This systematic review sources the latest neuroimaging evidence for the role of cognition-related brain networks in depression, and relates their abnormal functioning to symptoms of the disorder. Using theoretically informed and rigorous inclusion criteria, we integrate findings from 59 functional neuroimaging studies of adults with unipolar depression using a narrative approach. Results demonstrate that two distinct neurocognitive networks, the autobiographic memory network (AMN) and the cognitive control network (CCN), are central to the symptomatology of depression. Specifically, hyperactivity of the introspective AMN is linked to pathological brooding, self-blame, rumination. Anticorrelated under-engagement of the CCN is associated with indecisiveness, negative automatic thoughts, poor concentration, distorted cognitive processing. Downstream effects of this imbalance include reduced regulation of networks linked to the vegetative and affective symptoms of depression. The configurations of these networks can change between individuals and over time, plausibly accounting for both the variable presentation of depressive disorders and their fluctuating course. Framing depression as a disorder of neurocognitive networks directly links neurobiology to psychiatric practice, aiding researchers and clinicians alike.
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“Since its inception, support for this model has been rapidly mounting within the ID-domain (e.g. [56–59]).”
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,772
Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067
Correspondence of the brain's functional architecture during activation and rest
Smith, S. M., Fox, P. T., Miller, K. L., Glahn, D. C., Fox, P. M., Mackay, C. E., Filippini, N., Watkins, K. E., Toro, R., Laird, A. R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905267106 · Cited by 5,150
The cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495
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2 of the 177 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Berman, 2011, Depression, rumination and the default mode, Scan, 6, 548
- Gyurak, 2013, Cognitive-affective remediation training intervention in anxiety and depression, Neuropsychopharmacology, 38, S231
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Items 101–103 of 103
Les troubles cognitifs dans les épilepsies : de leur apparition à leur prise en charge
Forthoffer, N. (2023) · theses.fr (ABES) · doi:10.70675/6bff875bz747dz4f4az9177z2f67e3a02df4
Sun, F., Wang, F., 刘哲宁, Zhong, M., Yang, J., & Yang, J. (2026) · Bipolar Disorders · doi:10.1111/bdi.70124
Metadata
- Authors
- Rayner, G., Jackson, G., & Wilson, S.
- Affiliations
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Corresponding author
- Rayner, Genevieve
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 61
- Pages
- 53-65
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2208428407
- Cited by
- 104
- References
- 177
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 19 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 4 · 2017: 12 · 2016: 8
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Melbourne School of Psychological Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- major depressive disorder, cognitive control network, rumination, brooding, self-blame, indecision, negative automatic thoughts, attentional bias, vegetative symptoms, affective symptoms, neurocognitive networks, functional neuroimaging
- MeSH terms
- Brain, Cognition, Depression, Major Depressive Disorder, Humans, Nervous System Diseases, Functional Neuroimaging
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