The DOI matches its Crossref record; 194 of the 194 references it cites were found in a registry or an index.
Reproducibility and replicability of rodent phenotyping in preclinical studies
Open accessPublished version of a preprint
Abstract
The scientific community is increasingly concerned with the proportion of published "discoveries" that are not replicated in subsequent studies. The field of rodent behavioral phenotyping was one of the first to raise this concern, and to relate it to other methodological issues: the complex interaction between genotype and environment; the definitions of behavioral constructs; and the use of laboratory mice and rats as model species for investigating human health and disease mechanisms. In January 2015, researchers from various disciplines gathered at Tel Aviv University to discuss these issues. The general consensus was that the issue is prevalent and of concern, and should be addressed at the statistical, methodological and policy levels, but is not so severe as to call into question the validity and the usefulness of model organisms as a whole. Well-organized community efforts, coupled with improved data and metadata sharing, have a key role in identifying specific problems and promoting effective solutions. Replicability is closely related to validity, may affect generalizability and translation of findings, and has important ethical implications.
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“Animals, experimental units, or data points that are unaccounted for can lead to instances in which conclusions cannot be supported by the raw data [52].”
From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [52]
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Metadata
- Authors
- Kafkafi, N., Agassi, J., Chesler, E. J., Crabbe, J. C., Crusio, W. E., Eilam, D., Gerlai, R., Golani, I., Gomez-Marin, A., Heller, R., Iraqi, F., Jaljuli, I., Karp, N. A., Morgan, H., Nicholson, G., Pfaff, D. W., Richter, S. H., Stark, P. B., Stiedl, O., Stodden, V., Tarantino, L. M., Tucci, V., Valdar, W., Williams, R. W., Würbel, H., & Benjamini, Y.
- Affiliations
- Tel Aviv University (IL)
- Jackson Laboratory (US)
- Oregon Health & Science University (US)
- Centre National de la Recherche Scientifique (FR)
- University of Toronto (CA)
- AstraZeneca (United Kingdom) (GB)
- University of Oxford (GB)
- Rockefeller University (US)
- University of Münster (DE)
- University of California, Berkeley (US)
- Vrije Universiteit Amsterdam (NL)
- University of Illinois Urbana-Champaign (US)
- University of North Carolina at Chapel Hill (US)
- Italian Institute of Technology (IT)
- University of Tennessee Health Science Center (US)
- University of Bern (CH)
- Corresponding author
- Kafkafi, Neri
- ORCID
- Agassi, Joseph
- Chesler, Elissa J.
- Crabbe, John C.
- Crusio, Wim E.
- Eilam, David
- Gerlai, Robert
- Golani, Ilan
- Heller, Ruth
- Iraqi, Fuad
- Jaljuli, Iman
- Karp, Natasha A.
- Nicholson, George
- Pfaff, Donald W.
- Richter, S. Helene
- Stark, Philip B.
- Stiedl, Oliver
- Stodden, Victoria
- Tarantino, Lisa M.
- Tucci, Valter
- Valdar, William
- Williams, Robert W.
- Würbel, Hanno
- Benjamini, Yoav
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 87
- Pages
- 218-232
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC6071910
- OpenAlex
- W2952728789
- Cited by
- 215
- References
- 194
- Citations by year
- 2026: 20 · 2025: 23 · 2024: 26 · 2023: 25 · 2022: 26 · 2021: 25 · 2020: 37 · 2019: 21 · 2018: 9
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion, other-oa)
- PubMed Central (acceptedVersion, cc-by-nc-nd)
- HAL (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Spanish Ministry of Economy and Competitivity (Severo Ochoa Center of Excellence programme
- Topics
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Physical Sciences › Computer Science › Information Systems › Research Data Management Practices
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
- Keywords
- reproducibility, replicability, preclinical research, gene-environment interaction, research ethics, translational research
- MeSH terms
- Animals, Behavior, Animal, Phenotype, Research, Research Design, Rodentia, Reproducibility of Results, Models, Animal, Animal Experimentation, Information Dissemination
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