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Cited by 111Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

The DOI matches its Crossref record; 112 of the 113 references it cites were found in a registry or an index.

Therapeutic use of serotoninergic hallucinogens: A review of the evidence and of the biological and psychological mechanisms

dos Santos, Rafael Guimarães, Hallak, Jaime Eduardo Cecilio·2020·Neuroscience & Biobehavioral Reviews
DOI 10.1016/j.neubiorev.2019.12.001
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Abstract

Serotoninergic hallucinogens include drugs such as lysergic acid diethylamide (LSD), dimethyltryptamine (DMT) and psilocybin. Recent trials with single/few doses of these compounds show that they induce rapid and sustained antidepressive, anxiolytic, and antiaddictive effects. These effects are also observed in religious groups using the DMT-containing brew ayahuasca. The agonist action of these substances on 5-HT 2A receptors expressed in frontal and limbic areas increase glutamatergic transmission and neuroplasticity. These neurochemical effects are associated with acute alterations on self-perception and increases in introspection and positive mood, and with subacute and long-term decreases in psychiatric symptoms, increases in some personality traits such as openness, improvements in emotional processing, and increases in empathy. These are preliminary but promising results that should be further explored in controlled trials with larger sample sizes, especially considering that these compounds could be beneficial in the treatment of treatment-resistant psychiatric disorders.

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Crossref · 10.1016/j.neubiorev.2019.12.001

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Research works printed but not linked: 1

  1. Lima, 2006, Ayahuasca central nervous system effects: behavioral study, Arztezeitschrift Naturheilverfahren., 47, 476

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Metadata

Authors
dos Santos, R. G., & Hallak, J. E. C.
Affiliations
Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
ORCID
Hallak, Jaime Eduardo Cecilio
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2020-01
Volume
108
Pages
423-434
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/j.neubiorev.2019.12.001
OpenAlex
W2992322507
Cited by
111
References
113
Citations by year
2026: 4 · 2025: 8 · 2024: 16 · 2023: 22 · 2022: 27 · 2021: 17 · 2020: 17
FWCI
2.40
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
LSD, DMT, psilocybin, ayahuasca, 5-HT2A receptor agonism, antidepressant effects, anxiolytic effects, neuroplasticity, glutamatergic neurotransmission, self-perception, self-reflection, positive mood, personality traits, empathy, emotional processing, treatment-resistant psychiatric disorders, psychedelic therapy
MeSH terms
Social Cognition, Exploratory Behavior, Hallucinogens, Humans, Limbic System, Neuronal Plasticity, Prefrontal Cortex, Serotonin 5-HT2 Receptor Agonists

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