Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease
Abstract
Double-strand RNA dependent protein kinase (PKR) plays an important role in control of cell death. We previously reported that activation of PKR is associated with hippocampal neuronal loss in Alzheimer's disease (AD). Recent studies have reported that Parkinson's (PD) and Huntington's (HD) disease brains displayed progressive hippocampal neuronal loss in extrastriatal degeneration. However, association between PKR and hippocampal neuronal loss in PD and HD brains is not known. In this report, brain tissues from patients with PD and HD displayed strong induction of phosphorylated-PKR (p-PKR) in hippocampal neurons. Immunoblotting analysis also demonstrated that levels of nuclear p-PKR in the hippocampus affected by these diseases were increased compared with age-matched disease controls. These results suggest that a close association exists between PKR and extrastriatal degeneration in PD and HD pathology.
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PKR expression is increased with ageing or in neurodegenerative diseases such as AD, Parkinson's disease and Huntington's disease.
“Several studies revealed an increased PKR expression with ageing [47] or in neurodegenerative diseases such as AD, Parkinson's disease, Huntington's disease [48–50]”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [49]
PKR is active in other neurodegenerative diseases, including Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis.
“PKR is not specific to AD because it is also known to be active in other neurodegenerative diseases like Parkinson's disease [49, 170], Huntington's disease [48] and amyotrophic lateral sclerosis [96].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [49]
Cites
Chang, R. C. C., Wong, A. K. Y., Ng, H.-K., & Hugon, J. (2002) · NeuroReport · doi:10.1097/00001756-200212200-00011 · Cited by 289 · see citing works
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Zu, T., Guo, S., Bardhi, O., Ryskamp, D. A., Li, J., Khoramian Tusi, S., Engelbrecht, A., Klippel, K., Chakrabarty, P., Nguyen, L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005748117 · Cited by 133 · see citing works
Azorsa, D. O., Robeson, R. H., Frost, D., hoovet, B. M., Brautigam, G. R., Dickey, C., Beaudry, C., Basu, G. D., Holz, D. R., Hernandez, J. A., et al. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-25 · Cited by 88 · see citing works
PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease
Morel, M., Couturier, J., Lafay‐Chebassier, C., Paccalin, M., & Page, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00849.x · Cited by 47 · see citing works
- Authors
- BANDO, Y., ONUKI, R., KATAYAMA, T., MANABE, T., KUDO, T., TAIRA, K., & TOHYAMA, M.
- Affiliations
- Asahikawa Medical University (JP)
- National Institute of Advanced Industrial Science and Technology (JP)
- The University of Osaka (JP)
- Nara Medical University (JP)
- Corresponding author
- BANDO, Y
- ORCID
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 46
- Issue
- 1
- Pages
- 11-18
- ISSN
- 0197-0186 (ISSN-L)
- OpenAlex
- W1978262065
- Cited by
- 126
- References
- 1
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 8 · 2012: 8
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurochemistry International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- PKR, Parkinson's disease, Huntington's disease, hippocampal neuronal loss, neuronal cell death, neurodegeneration
- MeSH terms
- Adult, Aged, Cell Count, Cell Nucleus, Female, Hippocampus, Humans, Huntington Disease, Immunohistochemistry, Male, Middle Aged, Nerve Degeneration, Parkinson Disease, Phosphorylation, Cell Death, eIF-2 Kinase
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