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Cited by 30Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingNeuroprotection in Cerebral Ischemia

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The role of nitric oxide on visual-evoked potentials in MPTP-induced Parkinsonism in mice

Aras, Sinem, Tanriover, Gamze, Aslan, Mutay, Yargicoglu, Piraye, Agar, Aysel·2014·Neurochemistry International
DOI 10.1016/j.neuint.2014.04.014
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Abstract

The present study aimed to elucidate visual evoked potentials (VEP) changes in MPTP induced Parkinson's disease (PD) and investigate the possible benefical effects of neuronal (n) and inducible (i) nitric oxide synthase (NOS) inhibitors on altered VEPs, lipid peroxidation and apoptosis. 3 months old C57BL/6 mice were randomly divided into 6 groups which included control (C), 7-nitra indazole treated (7-NI), S-methylisothiourea (SMT) treated, 1,2,3,6-tetrahydropyridine (MPTP) treated, 7-NI+MPTP treated and SMT+MPTP treated. Motor activity of mice was evaluated via the pole test. At the end of the experimental period VEPs were recorded, brain and retina tissues were removed for biochemical analysis. Dopaminergic neuron death at substantia nigra (SN) was determined by immunohistochemical analysis of tyrosine hydroxylase (TH). Immunohistochemical staining was also performed to determine iNOS and nNOS in all tissue sections. Mice with experimental PD exhibited decreased motor activity. Dopaminergic cell death at pars compacta of SN (SNpc) was significantly increased in MPTP treated group compared to control. Diminished Parkinsonism symptoms were observed in 7-NI+MPTP and SMT+MPTP groups. Treatment with 7-NI and SMT decreased dopaminergic cell death in MPTP treated mice. Caspase-3 activity, nitrite/nitrate and 4-hydroxynonenal (4-HNE) levels were significantly increased in SN of MPTP treated mice compared to control. Treatment with 7-NI and SMT significantly decreased elevated caspase-3 activity, nitrite/nitrate and 4-HNE levels in SN of MPTP treated mice. No significant difference in above parameters were observed in the retina. VEP latencies were significantly prolonged in MPTP group compared to control group. 7-NI and SMT treatment caused a significant decrease in VEP latencies in MPTP treated mice compared to none treated MPTP group. This data shows that 7-NI and SMT improves prolonged VEP latencies. The protective effects of 7-NI and SMT on VEP alterations can be related to decreased dopaminergic cell death and reduced lipid peroxidation.

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Metadata

Authors
Aras, S., Tanriover, G., Aslan, M., Yargicoglu, P., & Agar, A.
Affiliations
Akdeniz University (TR)
ORCID
Venue
Neurochemistry International
Publisher
Elsevier BV
Published
2014-06
Volume
72
Pages
48-57
ISSN
0197-0186 (ISSN-L)
DOI
10.1016/j.neuint.2014.04.014
OpenAlex
W2046291010
Cited by
30
References
1
Citations by year
2026: 3 · 2025: 2 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 3 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 2
FWCI
1.96
Type
journal article
Language
en
Open access
closed
Locations
  • Neurochemistry International (publishedVersion)
  • PubMed (publishedVersion)
Funders
Akdeniz Üniversitesi
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
  • Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords
nitric oxide, visual evoked potentials, MPTP-induced parkinsonism, Parkinson's disease, neuronal nitric oxide synthase, inducible nitric oxide synthase, 7-nitroindazole, S-methylisothiourea, dopaminergic neuron death, substantia nigra, lipid peroxidation, apoptosis, caspase-3, 4-hydroxynonenal, nitrite/nitrate, VEP latency, neuroprotection
MeSH terms
Aldehydes, Animals, Evoked Potentials, Visual, Male, Mice, Inbred C57BL, Motor Activity, Nitric Oxide, Psychomotor Performance, Tyrosine 3-Monooxygenase, Lipid Peroxidation, Nitric Oxide Synthase, MPTP Poisoning, Mice, Caspase 3

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