Cited by 159Probiotics and Fermented FoodsHeart Rate Variability and Autonomic ControlBlood Pressure and Hypertension Studies

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Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats.

Tanida, Mamoru, Yamano, Toshihiko, Maeda, Keiko, Okumura, Nobuaki, Fukushima, Yoichi, Nagai, Katsuya·2005·Neuroscience Letters

DOI 10.1016/j.neulet.2005.07.036

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Abstract

Previously, it was shown that milk fermented with lactic acid bacteria lowers blood pressure, suggesting that metabolites or components of the bacteria have hypotensive action. To examine whether one of lactobacilli, Lactobacillus johnsonii La1 (LJLa1), a probiotic strain adhesive onto intestinal epithelial cells, or its metabolite has hypotensive action, and if so the mechanism of action, we determined the effects of intraduodenal injection of LJLa1 on blood pressure (BP) and the activity of autonomic nerves in urethane-anesthetized rats. Intraduodenal injection of LJLa1 reduced renal sympathetic nerve activity (RSNA) and BP and enhanced gastric vagal nerve activity (GVNA). Pre-treatment with thioperamide, a histaminergic H3-receptor antagonist, eliminated the effects of LJLa1 on RSNA, GVNA, and BP. Furthermore, bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN), the master circadian oscillator, abolished the suppression of RSNA and BP and the elevation of GVNA caused by LJLa1. These findings suggest that LJLa1 or its metabolites might lower BP by changing autonomic neurotransmission via the central histaminergic nerves and the suprachiasmatic nucleus in rats.

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Authors: Tanida, M., Yamano, T., Maeda, K., Okumura, N., Fukushima, Y., & Nagai, K.
Affiliations: Institute for Protein Research, The University of Osaka (JP)
Corresponding author: Nagai, Katsuya
ORCID: Tanida, Mamoru
Okumura, Nobuaki
Fukushima, Yoichi
Nagai, Katsuya
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 2005-12
Volume: 389
Issue: 2
Pages: 109-114
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/j.neulet.2005.07.036
OpenAlex: W2002714430
Cited by: 159
References: 18
Citations by year: 2026: 3 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 12 · 2021: 9 · 2020: 8 · 2019: 8 · 2018: 12 · 2017: 11 · 2016: 7 · 2015: 3 · 2014: 8 · 2013: 10 · 2012: 7
FWCI: 8.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: probiotics, renal sympathetic nerve activity, blood pressure, histamine H3 receptor, thioperamide, suprachiasmatic nucleus, circadian rhythm, autonomic neurotransmission, gut-brain axis, antihypertensive effect
MeSH terms: Adrenergic Fibers, Animals, Blood Pressure, Denervation, Duodenum, Histamine, Histamine Antagonists, Kidney, Lactobacillus, Male, Neural Pathways, Reaction Time, Suprachiasmatic Nucleus, Urethane, Vagus Nerve, Yogurt, Rats, Wistar, Receptors, Histamine H3, Anesthetics, Intravenous, Rats

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Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats.

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