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Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease

Shibata, Nobuto, Kawarai, Toshitaka, Lee, Joseph H., Lee, Hye-Seung, Shibata, Eri, Sato, Christine, Liang, Yan, Duara, Rajan, Mayeux, Richard P., St George-Hyslop, Peter H., Rogaeva, Ekaterina·2006·Neuroscience Letters
DOI 10.1016/j.neulet.2005.08.048
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Abstract

Recent studies have demonstrated that cholesterol metabolism has an important role in Alzheimer's disease (AD) pathogenesis, suggesting that cholesterol-related genes may be significant genetic risk factors for AD. Based on the results of genome-wide screens, along with biological studies, we selected three genes as candidates for AD risk factors: ATP-binding cassette transporter A1 (ABCA1), cholesterol 25-hydroxylase (CH25H) and cholesterol 24-hydroxylase (CH24H). Case-control of North American Caucasians and AD families of Caribbean Hispanic origin were examined. Although excellent biological candidates, the case-control dataset did not support the hypothesis that these three genes were associated with susceptibility to AD. Similarly, no association was found in the Caribbean Hispanic families for CH25H. However, we did observe a possible interaction between ABCA1 and APOE in the Hispanics.

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  • The association of the rs13500 CH25H promoter polymorphism with AD was not found in two subsequent studies nor in several large GWA studies, making this association 'suggestive' at best.

    “However, the association of this rs13500 CH25H promoter polymorphism was not found in two subsequent studies [87, 88] nor has an association between CH25H and AD risk be observed in several large GWA studies, making this association “suggestive” at best [89–91].”

    From 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner (2020) · cites this paper as [88]

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Research works printed but not linked: 17

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Metadata

Authors
Shibata, N., Kawarai, T., Lee, J. H., Lee, H.-S., Shibata, E., Sato, C., Liang, Y., Duara, R., Mayeux, R. P., St George-Hyslop, P. H., & Rogaeva, E.
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2006-01
Volume
391
Issue
3
Pages
142-146
ISSN
0304-3940
DOI
10.1016/j.neulet.2005.08.048
Cited by
59
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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