Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits
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Summary: A website for performing power calculations for the design of linkage and association genetic mapping studies of complex traits. Availability: The package is made available athttp://statgen.iop.kcl.ac.uk/gpc/ Contact: s.purcell@iop.kcl.ac.uk * To whom correspondence should be addressed.
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Given the sample size, the analysis had >90% power at α=2.5e-6 to detect any gene for which rare disruptive and damaging variants were present in 1% of schizophrenia cases, even if odds ratio was at least 3, and greater power for larger effects.
“Given the sample size, our analysis would have >90% power (at α = 2.5 × 10−6) to detect any gene for which rare, disruptive and damaging variants were present in 1% of schizophrenia cases, even if such variants had only a relatively modest effect size15 (odds ratio of at least 3, i.e. about 2% penetrance), and still greater power if effect sizes were larger.”
From Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia (2016) · cites this paper as [15]
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Self-citation
- Authors
- Purcell, S., Cherny, S. S., & Sham, P. C.
- Affiliations
- King's College London (GB)
- Centre for Human Genetics (GB)
- Venue
- Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-01-01
- Volume
- 19
- Issue
- 1
- Pages
- 149-150
- ISSN
- 1367-4803 (ISSN-L)
- 1367-4811
- OpenAlex
- W2126718294
- Cited by
- 2,057
- References
- 13
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 12 · 2023: 20 · 2022: 24 · 2021: 37 · 2020: 54 · 2019: 57 · 2018: 74 · 2017: 93 · 2016: 99 · 2015: 116 · 2014: 127 · 2013: 124 · 2012: 147
- FWCI
- 19.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Bioinformatics (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust (12562)
- National Institutes of Health
- Medical Research Council (G9700821)
- National Eye Institute (EY12562, R01EY012562)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- power analysis, gene mapping, linkage analysis, association mapping, complex traits, research design, genetic association studies
- MeSH terms
- Chromosome Mapping, Gene Frequency, Genetic Markers, Genetic Linkage, Models, Genetic, Pedigree, Software, Models, Statistical, Linkage Disequilibrium, Sample Size, Quantitative Trait, Heritable, Genetic Predisposition to Disease, Internet
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