Superoxide production after acute and chronic treatment with methylphenidate in young and adult rats
Open accessAbstract
The prescription of methylphenidate (MPH) has dramatically increased in this decade for attention deficit hyperactivity disorder (ADHD) treatment. The action mechanism of MPH is not completely understood and studies have been demonstrated that MPH can lead to neurochemical adaptations. Superoxide radical anion is not very reactive per se. However, severe species derived from superoxide radical anion mediate most of its toxicity. In this study, the superoxide level in submitochondrial particles was evaluated in response to treatment with MPH in the age-dependent manner in rats. MPH was administrated acutely or chronically at doses of 1, 2 or 10 mg/kg i.p. The results showed that the acute administration of MPH in all doses in young rats increased the production of superoxide in the cerebellum and only in the high dose (10mg/kg) in the hippocampus, while chronic treatment had no effect. However, acute treatment in adult rats had no effect on production of superoxide, but chronic treatment decreased the production of superoxide in the cerebellum at the lower doses. Our data suggest that the MPH treatment can influence on production of superoxide in some brain areas, but this effect depends on age of animals and treatment regime with MPH.
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Several studies have shown that MPH modulates oxidative stress in the brain, either increasing or reducing reactive oxygen species (ROS) depending on age, drug dose and brain region, and relate that to neural viability.
“Several studies have shown that MPH modulates oxidative stress in the brain [223, 224], either increasing or reducing reactive oxygen species (ROS) depending on age, drug dose and brain region, and relate that to neural viability.”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [223]
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Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder
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“Oxidative Stress Several studies have shown that MPH modulates oxidative stress in the brain [223, 224], either increasing or reducing reactive oxygen species (ROS) depending on age, drug dose and brain region, and relate that to neural viability.”
BackgroundSchmitz, F., Pierozan, P., Rodrigues, A. F., Biasibetti, H., Grings, M., Zanotto, B., Coelho, D. M., Vargas, C. R., Leipnitz, G., & Wyse, A. T. S. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0289-1 · Cited by 35 · see citing works
- Authors
- Gomes, K. M., Inácio, C. G., Valvassori, S. S., Réus, G. Z., Boeck, C. R., Dal-Pizzol, F., & Quevedo, J.
- Affiliations
- Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (BR)
- Corresponding author
- Quevedo, João
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 465
- Issue
- 1
- Pages
- 95-98
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2059135623
- Cited by
- 34
- References
- 7
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 4 · 2014: 7 · 2013: 2 · 2012: 2
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
- Universidade do Extremo Sul Catarinense
- Instituto Mente e Cérebro - Neurociência
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- methylphenidate, superoxide production, oxidative stress, attention deficit hyperactivity disorder, age-dependent effects, cerebellum, hippocampus, submitochondrial particles, neurotoxicity, young and adult rats
- MeSH terms
- Aging, Central Nervous System Stimulants, Analysis of Variance, Animals, Brain, Cerebellum, Corpus Striatum, Dose-Response Relationship, Drug, Hippocampus, Male, Methylphenidate, Mitochondria, Superoxides, Rats, Wistar, Rats
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