Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
When iron is present in the cytosol, dopamine can be oxidized into dopamine quinone (DAQ), which is highly reactive and toxic.
“When iron is present in the cytosol (as may occur more frequently with ageing)265,266, dopamine can be oxidized into dopamine quinone (DAQ), which is highly reactive and toxic267,268.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [267]
Cited by
Sorted by citations
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works
“Dopaminerincreased expression and subcellular redistribution of gic neurons may be a particularly fertile environment for the anti-PCD protein Bcl-xL and with activated PCDthe generation of ROS, as the metabolism of DA produces effector protease caspase-3 have also been found inhydrogen peroxide and superoxide radical…”
BackgroundOxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762 · see citing works
AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY
FEARNLEY, J. M., & LEES, A. J. (1991) · Brain · doi:10.1093/brain/114.5.2283 · Cited by 3,529 · see citing works
Oxidative stress in Parkinson's disease
Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053 · see citing works
“The presence of neuromelanin in dopaminergic cells attracted attention to the autoxidation of dopamine, semiquinone formation, and polymerization through which radical species are produced.(36,37) This led to the concept that the metabolism of dopamine might be responsible for the high basal levels of oxidative stress…”
BackgroundThe Role of Oxidative Stress in Parkinson's Disease
Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845 · see citing works
“Perturbations in this step again impact the levels of cytoplasmic free dopamine that is susceptible to be oxidized [64, 65].”
BackgroundBasal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease
Dexter, D. T., Carter, C. J., Wells, F. R., Javoy-Agid, F., Agid, Y., Lees, A. J., Jenner, P. G., & MARSDEN, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09133.x · Cited by 1,397 · see citing works
Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein
Lotharius, J., & Brundin, P. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn983 · Cited by 1,283 · see citing works
Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases
Nandi, A., Yan, L.-J., Jana, C. K., & Das, N. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9613090 · Cited by 1,185 · see citing works
“Mutant α-synuclein permeabilizes these vesicles causing leakage of the dopamine into the cytoplasm where it autooxidizes producing hydrogen peroxide, superoxide molecules, and toxic dopamine-quinone species creating oxidative stress conditions [122].”
BackgroundElucidating the Structure of Poly(dopamine)
Dreyer, D. R., Miller, D. J., Freeman, B. D., Paul, D. R., & Bielawski, C. W. (2012) · Langmuir · doi:10.1021/la204831b · Cited by 1,086 · see citing works
Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine
Eisenhofer, G., Kopin, I. J., & Goldstein, D. S. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.1 · Cited by 1,072 · see citing works
“Mechanisms of catecholamine-induced neurotoxicity are usually ascribed to nonenzymatic auto-oxidation of catecholamines to form reactive quinones (Graham, 1978; Hastings et al., 1996a), associated production of cytotoxic free radicals (Cohen, 1983; Masserano et al., 1996; Offen et al., 1996), and…”
BackgroundThe oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
Fahn, S., & Cohen, G. (1992) · Annals of Neurology · doi:10.1002/ana.410320616 · Cited by 927 · see citing works
Quinone chemistry and toxicity
Monks, T. J., Hanzlik, R. P., Cohen, G. M., Ross, D., & Graham, D. G. (1992) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(92)90273-u · Cited by 765 · see citing works
Self-citationSurface Modification of Water Purification Membranes
Miller, D. J., Dreyer, D. R., Bielawski, C. W., Paul, D. R., & Freeman, B. D. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201601509 · Cited by 749 · see citing works
Bains, J. S., & Shaw, C. A. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00045-3 · Cited by 716 · see citing works
Grant, P. S., Kuepper, Y., Mueller, E. A., Wielpuetz, C., Mason, O. J., & Hennig, J. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00001 · Cited by 719 · see citing works
“…MAO-A would have the highest levels of synaptic dopamine and thereby moderately high UnEx-scores due to the abundance of dopamine itself as well as to an increased rate of dopamine-quinone formation (Graham, 1978; Graham et al., 1978), a secondary mechanism in dopamine-neurotoxicity (Grant, 2011).”
BackgroundRhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
Parkinson disease: from pathology to molecular disease mechanisms
Dexter, D. T., & Jenner, P. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.018 · Cited by 716 · see citing works
“Starting from the idea of free radical production resulting from increased chemical and enzymatic oxidation of dopamine, through to the mechanism of action of toxins such 6-hydroxydopamine (6-OHDA) and paraquat, to evidence from postmortem and clinical investigations, oxidative stress and the resulting oxidative damag…”
BackgroundBerman, S. B., & Hastings, T. G. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731127.x · Cited by 664 · see citing works
Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid
Packer, L., Tritschler, H. J., & Wessel, K. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00269-9 · Cited by 639 · see citing works
Zhang, J., Perry, G. L., Smith, M. A., Robertson, D., Olson, S. J., Graham, D. G., & Montine, T. J. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65396-5 · Cited by 636 · see citing works
“First, PD is associated with both increased levels of nigral iron,2 a catalytic agent for production of hydroxyl radical ( OH), and increased Mn superoxide dismutase activity.3 Second, midbrain levels of reduced glutathione are diminished in PD patients.4 Third, there is evidence of increased oxidative damage in midbr…”
BackgroundSelf-citationA Role for α-Synuclein in the Regulation of Dopamine Biosynthesis
Perez, R. G., Waymire, J. C., Lin, E., Liu, J. J., Guo, F., & Zigmond, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03090.2002 · Cited by 598 · see citing works
“, 2001), cytosolic DA can form DA-quinone and reactive oxygen species (ROS) that are neurotoxic (Graham, 1978; Hastings et al., 1996; Stokes et al., 1999; Lotharius and O’Malley, 2000), -synuclein itself is modified by DA quinone (Conway et al.”
BackgroundFunctional changes of the basal ganglia circuitry in Parkinson's disease
Blandini, F., Nappi, G., Tassorelli, C., & Martignoni, E. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00067-2 · Cited by 578 · see citing works
Tansey, M. G., McCoy, M. K., & Frank-Cannon, T. C. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.07.004 · Cited by 580 · see citing works
“Under normal conditions, DA neurons must withstand a high rate of oxidant species production because the dopamine biosynthetic pathway involves the creation of a number of reactive dopamine metabolites such as DA-quinone which are toxic to neurons (Graham, 1978; Stokes et al., 1999).”
BackgroundMetals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury
Farina, M., Ávila, D. S., da Rocha, J. B. T., & Aschner, M. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.12.006 · Cited by 558 · see citing works
“3) (Graham, 1978).”
Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections.
Hastings, T. G., Lewis, D. A., & Zigmond, M. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.1956 · Cited by 547 · see citing works
Jenner, P. G., Dexter, D. T., Sian, J., Schapira, A. H. V., & MARSDEN, C. D. (1992) · Annals of Neurology · doi:10.1002/ana.410320714 · Cited by 545 · see citing works
Hirsch, E. C., Brandel, J. ‐., Galle, P., Javoy‐Agid, F., & Agid, Y. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08170.x · Cited by 537 · see citing works
Pacelli, C., Giguère, N., Bourque, M.-J., Lévesque, M., Slack, R. S., & Trudeau, L. (2015) · Current Biology · doi:10.1016/j.cub.2015.07.050 · Cited by 530 · see citing works
“However, our results do not exclude that, in addition, other sources of ROS such as those arising from the oxidative metabolism of DA itself [32] could also play a role.”
ResultAsanuma, M., Miyazaki, I., & Ogawa, N. (2003) · Neurotoxicity Research · doi:10.1007/bf03033137 · Cited by 518 · see citing works
“, 1976; Graham, 1978). Furthermore, Hastings (1995) reported that DA can be enzymatically oxidized by prostaglandin H synthase MASATO ASANUMA et al.”
BackgroundInfluentialOxidative stress and inflammation in Parkinson's disease: is there a causal link?
Hald, A., & Lotharius, J. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.01.013 · Cited by 506 · see citing works
Invited Review Free radicals and the pathobiology of brain dopamine systems
Cadet, J. L., & Brannock, C. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(97)00031-4 · Cited by 499 · see citing works
Lu, Z., Nie, G., Belton, P., Tang, H., & Zhao, B. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.10.010 · Cited by 485 · see citing works
“6-OHDA-induced ROS will initially deplete intracellular glutathione and increase cellular vulnerability (Kostrzewa and Jacobowitz, 1974; Kumar et al., 1995; Cohen and Heikkia, 1974; Graham, 1978; Hastings, 1995; Hara et al., 2003).”
BackgroundOxidative stress and cellular pathologies in Parkinson’s disease
Puspita, L., Chung, S. Y., & Shim, J. (2017) · Molecular Brain · doi:10.1186/s13041-017-0340-9 · Cited by 486 · see citing works
A Guide to Neurotoxic Animal Models of Parkinson's Disease
Tieu, K. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009316 · Cited by 483 · see citing works
Occupational exposures to metals as risk factors for Parkinson's disease
Gorell, J. M., Johnson, C. C., Rybicki, B. A., Peterson, E. L., Kortsha, G. X., Brown, G. G., & Richardson, R. J. (1997) · Neurology · doi:10.1212/wnl.48.3.650 · Cited by 479 · see citing works
The Flavonoid Baicalein Inhibits Fibrillation of α-Synuclein and Disaggregates Existing Fibrils
Zhu, M., Rajamani, S., Kaylor, J. J., Han, S., Zhou, F., & Fink, A. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403129200 · Cited by 475 · see citing works
The diverse functionality of NQO1 and its roles in redox control
Ross, D., & Siegel, D. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101950 · Cited by 482 · see citing works
Jicha, G. A., Berenfeld, B., & Davies, P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990315)55:6 · Cited by 123 · see citing works
Glutathione peroxidase, glial cells and Parkinson's disease
Damier, P., Hirsch, É. C., Zhang, P., Agid, Y., & Javoy-Agid, F. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90175-f · Cited by 466 · see citing works
Sulzer, D. L., Bogulavsky, J. J., Larsen, K. E., Behr, G. G., Karatekin, E., Kleinman, M. H., Turro, N. J., Krantz, D. E., Edwards, R. H., Greene, L. A., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.11869 · Cited by 460 · see citing works
LaVoie, M. J., & Hastings, T. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01484.1999 · Cited by 449 · see citing works
“Under such conditions, DA may oxidize to form superoxide and hydrogen peroxide, which can then form the hydroxyl radical in the presence of transition metals (Graham, 1978).”
BackgroundGlutathione metabolism and Parkinson's disease
Smeyne, M., & Smeyne, R. J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.001 · Cited by 436 · see citing works
“Inside the cell, DA quinones react with the sulfhydryl groups of the free amino acid cysteine, cysteine found in glutathione, and other cysteine residues to covalently modify proteins [31,32] that cause cellular toxicity and, in some cases, cell death [30,31,33,34].”
Oxidative stress and regulated cell death in Parkinson’s disease
Dionísio, P. A., Amaral, J. D., & Rodrigues, C. M. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101263 · Cited by 436 · see citing works
Baltazar, M. T., Dinis‐Oliveira, R. J., Bastos, M. D. L., Tsatsakis, A. M., Duarte, J. A., & Carvalho, F. D. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.01.039 · Cited by 410 · see citing works
Reduced Vesicular Storage of Dopamine Causes Progressive Nigrostriatal Neurodegeneration
Caudle, W. M., Richardson, J. R., Wang, M. Z., Taylor, T. N., Guillot, T. S., McCormack, A. L., Colebrooke, R. E., Monte, D. A. D., Emson, P. C., & Miller, G. W. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0319-07.2007 · Cited by 389 · see citing works
“Cytosolic accumulation of dopamine and subsequent breakdown leads to the generation of reactive oxygen species, as well as highly reactive quinones (Graham, 1978; Montine et al., 1997), which may contribute to the pathophysiology of PD (Hastings et al.”
BackgroundInfluentialNeuroinflammation, oxidative stress, and the pathogenesis of Parkinson’s disease
Mosley, R. L., Benner, E. J., Kadiu, I., Thomas, M., Boska, M. D., Hasan, K. M., Laurie, C. D., & Gendelman, H. E. (2006) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2006.09.006 · Cited by 388 · see citing works
“Catecholamines particularly dopamine, can be metabolized by endogenous enzymes such as monoamine oxidases (MAO) or spontaneously break down by autooxidation to yield H2O2 and dopamine-quinones [86-88].”
BackgroundCassarino, D. S., & Bennett, J. P. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00046-0 · Cited by 379 · see citing works
The MPTP model of Parkinson's disease
Smeyne, R. J., & Jackson-Lewis, V. R. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.09.017 · Cited by 377 · see citing works
Chung, C. Y., Seo, H., Sonntag, K. C., Brooks, A., Lin, L., & Isacson, O. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi178 · Cited by 361 · see citing works
“Efficient DA sequestration into vesicles protects DA neurons from the deleterious effects of DA oxidation (82).”
BackgroundMonte, D. A. D. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00501-5 · Cited by 356 · see citing works
Rebec, G. V., & Pierce, R. C. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90052-3 · Cited by 354 · see citing works
Effect of Mutant α-Synuclein on Dopamine Homeostasis in a New Human Mesencephalic Cell Line
Lotharius, J., Barg, S., Wiekop, P., Lundberg, C., Raymon, H. K., & Brundin, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205518200 · Cited by 349 · see citing works
The Role of Oxidative Stress in Parkinson’s Disease
Chang, K., & Chen, C. (2020) · Antioxidants · doi:10.3390/antiox9070597 · Cited by 357 · see citing works
Toxicity of 6‐hydroxydopamine and dopamine for dopaminergic neurons in culture
Michel, P. P., & Hefti, F. F. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490260405 · Cited by 339 · see citing works
Effects ofl-DOPA on extracellular dopamine in striatum of normal and 6-hydroxydopamine-treated rats
Abercrombie, E. D., Bonatz, A. E., & Zigmond, M. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)91318-b · Cited by 335 · see citing works
Free radical pathology and antioxidant defense in schizophrenia: a review
Mahadik, S. P., & Mukherjee, S. (1996) · Schizophrenia Research · doi:10.1016/0920-9964(95)00049-6 · Cited by 330 · see citing works
Paraquat exposure as an etiological factor of Parkinson's disease
Dinis‐Oliveira, R. J., Remião, F., Carmo, H., Duarte, J. A., Navarro, A. S., Bastos, M. D. L., & Carvalho, F. D. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.05.012 · Cited by 329 · see citing works
“Comparing to other neuronal cell types, dopaminergic cells are much more sensitive to oxidative injury due to the participation of DA in harmful oxidative reactions (Fitsanakis et al., 2002; Graham, 1978).”
BackgroundLipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder
Kuloglu, M., Ustundag, B., Atmaca, M., Canatan, H., Tezcan, A. E., & Cinkilinc, N. (2002) · Cell Biochemistry and Function · doi:10.1002/cbf.940 · Cited by 321 · see citing works
Ono, K., & Yamada, M. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03707.x · Cited by 320 · see citing works
Drechsel, D. A., & Patel, M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.02.008 · Cited by 314 · see citing works
“The premise of this hypothesis is based on landmark studies demonstrating the potential for the generation of hydrogen peroxide (H2O2) and other ROS during the oxidative metabolism of DA [19], which exposes DAergic neurons of the SNpc to chronic oxidative stress compared to other regions of the brain.”
BackgroundDopamine Induces Apoptosis through an Oxidation-involved SAPK/JNK Activation Pathway
Luo, Y., Umegaki, H., Wang, X., Abe, R., & Roth, G. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3756 · Cited by 310 · see citing works
The Parkinsonism-inducing Drug 1-Methyl-4-phenylpyridinium Triggers Intracellular Dopamine Oxidation
Lotharius, J., & O’Malley, K. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005385200 · Cited by 306 · see citing works
Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: An overview
Mazza, M., Pomponi, M., Janiri, L., Bria, P., & Mazza, S. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.07.010 · Cited by 306 · see citing works
Role of dopamine in the pathophysiology of Parkinson’s disease
Zhou, Z.-D., Yi, L.-X., Wang, D. Q., Lim, T. M., & Tan, E.-K. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00378-6 · Cited by 287 · see citing works
“DOQ and AM can react and conjugate with many biomolecules, including protein residues cysteine and tyrosine with sulfhydryl and hydroxyl groups, whereas polymerization of AM will form neuromelanin (NM), an insoluble granular pigment in SN [5, 25, 26].”
BackgroundKinetic and Structural Analysis of the Early Oxidation Products of Dopamine
Bisaglia, M., Mammi, S., & Bubacco, L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610893200 · Cited by 303 · see citing works
Ben‐Shachar, D., Eshel, G., Finberg, J. P. M., & Youdim, M. B. H. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb11444.x · Cited by 299 · see citing works
Harischandra, D. S., Ghaisas, S., Zenitsky, G. D., Jin, H., Kanthasamy, A., Anantharam, V., & Kanthasamy, A. G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00654 · Cited by 290 · see citing works
“These quinones also undergo intramolecular cyclization and oxidative reactions to produce neuromelanin (Graham, 1978; Hermida-Ameijeiras et al., 2004).”
BackgroundIntraneuronal dopamine-quinone synthesis: a review
Sulzer, D., & Zecca, L. (1999) · Neurotoxicity Research · doi:10.1007/bf03033289 · Cited by 284 · see citing works
“catecholamines in the presence of molecular oxygen in vitro produces hydrogen peroxide, hydroxyl radical, and superoxide (Graham, 1978; Klegeris et al., 1995; Marinho and Manso, 1993).”
InfluentialMitochondria and degenerative disorders
Orth, M., & Schapira, A. H. V. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1425 · Cited by 278 · see citing works
Giasson, B. I., Ischiropoulos, H., Lee, V. M. ‐., & Trojanowski, J. Q. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00804-3 · Cited by 281 · see citing works
Marchitti, S. A., Deitrich, R. A., & Vasiliou, V. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.2.1 · Cited by 282 · see citing works
“In support of this contention, it has been postulated that increased dopamine metabolism, occurring after an initial loss of dopamine neurons, plays a role in the progression of nigrostriatal degeneration in PD (Graham, 1978; Cohen et al., 1997).”
Taylor, T. N., Caudle, W. M., Shepherd, K. R., Noorian, A. R., Jackson, C. R., Iuvone, P. M., Weinshenker, D., Greene, J. G., & Miller, G. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1495-09.2009 · Cited by 278 · see citing works
“Catecholamines have the intrinsic ability to auto-oxidize, yielding reactive oxygen species and cysteinyl adducts; likewise, serotonin has an oxidizable indole ring (Graham, 1978; Jenner, 1998, 2003; Guillot and Miller, 2009).”
BackgroundLotharius, J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.20.2395 · Cited by 267 · see citing works
Biochemical and toxicological properties of the oxidation products of catecholamines
Bindoli, A., Rigobello, M. P., & Deeble, D. J. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90182-g · Cited by 264 · see citing works
Lotharius, J., Falsig, J., van Beek, J., Payne, S., Dringen, R., Brundin, P., & Leist, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1746-05.2005 · Cited by 262 · see citing works
“Nigral dopaminergic neurons are under continuous oxidative stress because of the unstable nature of their neurotransmitter dopamine (Graham, 1978; Maker et al., 1981), the adverse effects of which are further enhanced by high concentrations of iron in the substantia nigra (SN) (for review, see…”
BackgroundTyrosine Hydroxylase and Parkinson’s Disease
Haavik, J., & Toska, K. (1998) · Molecular Neurobiology · doi:10.1007/bf02741387 · Cited by 263 · see citing works
Li, J., Zhu, M., Manning-Bog, A., Monte, D. A. D., & Fink, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0770fje · Cited by 257 · see citing works
Neurodegeneration and neuroprotection in Parkinson disease
Fahn, S., & Sulzer, D. L. (2004) · Neurotherapeutics · doi:10.1602/neurorx.1.1.139 · Cited by 266 · see citing works
Toxic and Protective Effects of l ‐DOPA on Mesencephalic Cell Cultures
Mytilineou, C., Han, S., & Cohen, G. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13642.x · Cited by 244 · see citing works
Environmental Factors in Parkinson’s Disease
Monte, D. A. D., Lavasani, M., & Manning-Bog, A. (2002) · NeuroToxicology · doi:10.1016/s0161-813x(02)00099-2 · Cited by 241 · see citing works
Unregulated Cytosolic Dopamine Causes Neurodegeneration Associated with Oxidative Stress in Mice
Chen, L., Ding, Y., Cagniard, B., Laar, A. D. V., Mortimer, A. D., Chi, W., Hastings, T. G., Kang, U. J., & Zhuang, X. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3602-07.2008 · Cited by 238 · see citing works
“Dopamine is a very reactive molecule compared with other neurotransmitters, and dopamine degradation naturally produces oxidative species (Graham, 1978).”
BackgroundLinert, W., Herlinger, E., Jameson, R. F., Kienzl, E., Jellinger, K. A., & Youdim, M. B. H. (1996) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(96)00020-8 · Cited by 238 · see citing works
Zhang, J., Fitsanakis, V. A., Gu, G., Jing, D., Ao, M., Amarnath, V., & Montine, T. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01525.x · Cited by 238 · see citing works
Alpha-synuclein, lipids and Parkinson’s disease
Ruipérez, V., Darios, F. D., & Davletov, B. A. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.05.004 · Cited by 233 · see citing works
Manganese poisoning and the attack of trivalent manganese upon catecholamines
Archibald, F. S., & Tyree, C. M. (1987) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(87)90621-7 · Cited by 233 · see citing works
Murer, M. G., Dziewczapolski, G., Menalled, L., et al. (1998) · Annals of Neurology · doi:10.1002/ana.410430504 · Cited by 232 · see citing works
Levodopa in the treatment of Parkinson's disease
Schapira, A. H. V., Emre, M., Jenner, P., & Poewe, W. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02697.x · Cited by 231 · see citing works
Kästner, A., Hirsch, É. C., Lejeune, O., Javoy-Agid, F., Rascol, O., & Agid, Y. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08350.x · Cited by 228 · see citing works
Strathearn, K. E., Yousef, G. G., Grace, M. H., Roy, S. L., Tambe, M. A., Ferruzzi, M. G., Wu, Q.-L., Simon, J. E., Lila, M. A., & Rochet, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.047 · Cited by 226 · see citing works
“Dopaminergic neurons of the SNpc contain relatively high basal levels of ROS resulting from the metabolism and auto-oxidation of dopamine (Betarbet et al., 2000; Graham, 1978).”
BackgroundSpontaneous autoxidation of dopamine
Herlinger, E., Jameson, R. F., & Linert, W. (1995) · Journal of the Chemical Society Perkin Transactions 2 · doi:10.1039/p29950000259 · Cited by 227 · see citing works
Oxygen Radicals and Neuropsychiatric Illness
Lohr, J. B. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810360061009 · Cited by 225 · see citing works
Neurotoxicity of methamphetamine: Main effects and mechanisms
Jayanthi, S., Daiwile, A. P., & Cadet, J. L. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113795 · Cited by 230 · see citing works
Clemente‐Suárez, V. J., Redondo-Flórez, L., Beltrán-Velasco, A. I., Ramos‐Campo, D. J., Belinchón-deMiguel, P., Martínez‐Guardado, I., Dalamitros, A. A., Sepulveda, R. A. Y., Martín-Rodríguez, A., & Tornero-Aguilera, J. F. (2023) · Biomedicines · doi:10.3390/biomedicines11092488 · Cited by 241 · see citing works
Neuronal Apoptosis in Neurodegeneration
Okouchi, M., Ekshyyan, O. Y., Maracine, M., & Aw, T. Y. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1511 · Cited by 219 · see citing works
“Dopamine is metabolized by monoamine oxidase which generates H 2 O 2 (225), or is autooxidized to yield O 2 (cid:2) (cid:6) radicals, H 2 O 2 , and dopamine-quinone species (116).”
Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
Mor, D. E., Tsika, E., Mazzulli, J. R., Gould, N. S., Kim, H., Daniels, M. J., Doshi, S., Gupta, P., Grossman, J., Tan, V. X., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4641 · Cited by 219 · see citing works
“At cytosolic pH, dopamine auto-oxidizes to form reactive quinone species, hydrogen peroxide, and other electrophiles (2).”
BackgroundFleckenstein, A. E., Gibb, J. W., & Hanson, G. R. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00639-7 · Cited by 213 · see citing works
Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction
Park, J., Kim, S. Y., Cha, G., Lee, S. B., Kim, S., & Chung, J. (2005) · Gene · doi:10.1016/j.gene.2005.06.040 · Cited by 211 · see citing works
Glutathione and Parkinson's disease: Is this the elephant in the room?
Zeevalk, G. D., Razmpour, R., & Bernard, L. P. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.01.017 · Cited by 209 · see citing works
Oxidative Stress and Neurodegenerative Disorders
Sun, A. Y., & Chen, Y. (1998) · Journal of Biomedical Science · doi:10.1007/bf02255928 · Cited by 214 · see citing works
Can the brain be protected through exercise? Lessons from an animal model of parkinsonism☆
Smith, A. D., & Zigmond, M. J. (2003) · Experimental Neurology · doi:10.1016/j.expneurol.2003.08.017 · Cited by 209 · see citing works
- Authors
- GRAHAM, D. G.
- Affiliations
- Duke Medical Center (US)
- Corresponding author
- GRAHAM, DOYLE G.
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 1978-07
- Volume
- 14
- Issue
- 4
- Pages
- 633-643
- ISSN
- 0026-895X (ISSN-L)
- OpenAlex
- W2211987820
- Cited by
- 1,126
- References
- 0
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 20 · 2020: 23 · 2019: 26 · 2018: 29 · 2017: 30 · 2016: 26 · 2015: 29 · 2014: 26 · 2013: 26 · 2012: 49
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- catecholamines, autoxidation, periodate oxidation, 6-hydroxydopamine, dopamine, norepinephrine, epinephrine, aminochrome, adrenochrome, o-quinones, p-quinones, cyclization, tautomerism, neuromelanin
- MeSH terms
- Catecholamines, Dopamine, Epinephrine, Hydroxydopamines, Melanins, Norepinephrine, Oxidation-Reduction, Quinones, Monophenol Monooxygenase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
