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Cited by 33Transcranial Magnetic Stimulation StudiesMotor Control and AdaptationNeural and Behavioral Psychology Studies

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Age-related differences in human corticospinal excitability during simple reaction time.

Levin, Oron, Cuypers, Koen, Netz, Yael, Thijs, Herbert, Nuttin, Bart, Helsen, Werner F., Meesen, Raf L.J.·2011·Neuroscience Letters
DOI 10.1016/j.neulet.2010.09.072
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Abstract

Age-related declines in central processing may delay the facilitation of corticospinal (CS) tracts that underlie emergence of voluntary responses to external stimuli. To explore this effect, single pulse transcranial magnetic stimulation (TMS) was applied to the left motor cortex at different latencies from the go-signal (auditory tone) during a simple reaction time (SRT) task with the right or left thumb [i.e. right (RHM) or left hand move (LHM)]. Motor evoked potentials (MEPs) in the right abductor pollicis brevis (APB) were recorded from eleven healthy right-handed participants (aged 22-65; six young adults and five old adults). Both age groups showed significant facilitation of CS excitability approximately 100-120 ms from the onset of the go-signal in the RHM SRT that occurred before the onset of EMG voluntary burst, with no evidence for motor slowing in old adults. Old adults demonstrated a significant facilitation of MEPs in the time that preceded the go-signal for RHM SRT and a marked depression of CS excitability in preparation for the LHM SRT that was sustained up to 80 ms after the onset of the go-signal. Both effects were not seen in young adults. While the small number of participants may hinder the generality of the present observations, this pilot study suggests for the first time that old adults implemented selective tuning of CS excitability prior to the onset of the go command to speed up their response generation.

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  • Previous electrophysiological studies have found age-related reductions in corticospinal excitability.

    “For example, previous electrophysiological studies have found age-related reductions in corticospinal excitability (Levin et al., 2011).”

    From Factors influencing the latency of simple reaction time (2015) · cites this paper as Levin et al., 2011

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References 28 · Cited by 33

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Metadata

Authors
Levin, O., Cuypers, K., Netz, Y., Thijs, H., Nuttin, B., Helsen, W. F., & Meesen, R. L. J.
Affiliations
  • KU Leuven (BE)
  • Hasselt University (BE)
Corresponding author
Levin, Oron
ORCID
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2011-01
Volume
487
Issue
1
Pages
53-57
ISSN
0304-3940 (ISSN-L)
DOI
10.1016/j.neulet.2010.09.072
OpenAlex
W1985653388
Cited by
33
References
28
Citations by year
2026: 3 · 2025: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 1 · 2012: 4
FWCI
1.35
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Document Server@UHasselt (UHasselt) (submittedVersion)
  • Lirias (KU Leuven) (submittedVersion)
Funders
  • Universiteit Hasselt
  • Vlaamse regering
  • Bijzonder Onderzoeksfonds UGent
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
corticospinal excitability, aging, simple reaction time, motor cortex, motor evoked potentials, abductor pollicis brevis, motor slowing, response preparation, hand selection
MeSH terms
Acoustic Stimulation, Adult, Aged, Aging, Electromyography, Humans, Functional Laterality, Middle Aged, Pyramidal Tracts, Reaction Time, Time Factors, Evoked Potentials, Motor, Transcranial Magnetic Stimulation, Young Adult

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