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Cited by 243Neural and Behavioral Psychology StudiesMotor Control and AdaptationCognitive Functions and Memory

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Sensorimotor slowing with ageing is mediated by a functional dysregulation of motor-generation processes: evidence from high-resolution event-related potentials.

Yordanova, J.·2004·Brain
DOI 10.1093/brain/awh042
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Abstract

The objective of the present study was to identify the origin(s) of ageing-related behavioural slowing in sensorimotor tasks. For this aim, event-related potentials (ERPs) were analysed at 64 electrodes to evaluate the strength and timing of different stages of information processing in the brain. Electrophysiological indices of stimulus processing, sensorimotor integration/response selection and motor-related processing were used to compare the processing speed of young (n = 13, mean age = 22.5 years) and older adults (n = 14, mean age = 58.3 years) in simple- and choice-reaction tasks presented in two modalities, auditory and visual. The behavioural results showed significant ageing-related slowing, but only in the choice-reaction task. The quantification of separate central processing stages, in combination with advanced ERP methodology, helped to reveal that this slowing did not originate from the early processes of stimulus processing and response selection. Instead, it was produced by slower activation patterns over the contralateral motor cortex underlying response generation. It is concluded that ageing is accompanied by a functional dysregulation of motor cortex excitability during sensorimotor processing, with this deficit becoming progressively evident with greater task complexity.

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  • ERP studies find significant age-related delays in the time between the onset of motor cortex activation and the onset of EMG activity in the muscles executing the response.

    “This hypothesis is also supported by ERP studies, which find significant age-related delays in the time between the onset of motor cortex activation and the onset of EMG activity in the muscles executing the response (Yordanova et al., 2004; van de Laar et al., 2012).”

    From Age-related slowing of response selection and production in a visual choice reaction time task (2015) · cites this paper as Yordanova et al., 2004

    In “Motor-related processes: MRP” (page unavailable), the paper reports that motor-cortex potential onset occurred significantly earlier before the response in older adults, but only in the choice-reaction task. It does not report a significant age-related difference in the interval from cortical onset specifically to EMG onset; it says EMG activation patterns did not differ across age groups. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Many studies find larger absolute and relative age-related increases in CRT latencies than SRTs.

    “This is in agreement with many studies that find larger absolute and relative age-related increases in CRT latencies than SRTs (Yordanova et al., 2004; Anstey et al., 2005; Deary and Der, 2005; Deary et al., 2010; Era et al., 2011).”

    From Age-related slowing of response selection and production in a visual choice reaction time task (2015) · cites this paper as Yordanova et al., 2004

  • SDT latencies (120 ms after correcting for display delays) were similar to the latencies of early cortical components of the visual evoked potential.

    “Interestingly, SDT latencies (120 ms after correcting for display delays in the monitor) were similar to the latencies of early cortical components of the visual evoked potential (Yordanova et al., 2004)”

    From Factors influencing the latency of simple reaction time (2015) · cites this paper as Yordanova et al., 2004

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Metadata

Authors
Yordanova, J.
Affiliations
Bulgarian Academy of Sciences (BG)
Corresponding author
Yordanova, J.
ORCID
Yordanova, J.
Venue
Brain
Publisher
Oxford University Press (OUP)
Published
2004-02-01
Volume
127
Issue
2
Pages
351-362
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
DOI
10.1093/brain/awh042
OpenAlex
W2071116180
Cited by
243
References
3
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 13 · 2021: 12 · 2020: 11 · 2019: 9 · 2018: 12 · 2017: 9 · 2016: 10 · 2015: 14 · 2014: 20 · 2013: 22 · 2012: 16
FWCI
3.87
Type
journal article
Language
en
Open access
closed
Locations
  • Brain (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
aging, motor cortex excitability, response generation, event-related potentials, processing speed, choice reaction time, response selection, stimulus processing, motor cortex activation, task complexity, auditory and visual stimuli
MeSH terms
Acoustic Stimulation, Adult, Aging, Brain Mapping, Choice Behavior, Electroencephalography, Female, Humans, Male, Middle Aged, Motor Cortex, Neuropsychological Tests, Photic Stimulation, Psychomotor Performance, Reaction Time, Evoked Potentials, Motor

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