Vagus nerve stimulation inhibits heroin-seeking behavior induced by heroin priming or heroin-associated cues in rats
Abstract
Vagus nerve stimulation has been used for the treatment of neuropsychiatric disorders, such as epilepsy. However, little is known whether it is also effective for the treatment of heroin dependence, in particular for relapse to heroin seeking. In the present study, we investigated the effects of vagus nerve stimulation on reinstatement (relapse) of heroin-seeking behavior induced by heroin priming or heroin-associated cues. The rats were trained for heroin self-administration for 14days and followed by extinction training in which heroin was replaced by saline and heroin-associated cues were turned off. In addition, animals were also received daily electric stimulation of vagus nerve (30Hz, pulse width of 0.5ms, 0.5mA (low-intensity) or 1mA (high-intensity); 30s on, 5min off; 10 continuous cycle per day) or false stimulation during extinction training. We found that such vagus nerve stimulation significantly inhibited heroin priming (0.25mg/kg, s.c.) - or heroin-associated conditioned cue-induced reinstatement of drug-seeking behavior, when compared to false stimulation control. Further, such a behavioral inhibition was correlated to a reduction in the expression of FosB and an increase in the expression of phosphorylation of cAMP response element binding protein (p-CREB) in nucleus accumbens. The data suggest that vagus nerve stimulation may inhibit heroin- or heroin cue-induced relapse, possibly by regulation of the expression of Fos and CREB in nucleus accumbens.
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VNS inhibits heroin-seeking behavior induced by heroin priming or heroin-associated cues in rats.
“VNS inhibits heroin-seeking behavior induced by heroin priming or heroin-associated cues in rats [119] and also reduces cocaine seeking and alters plasticity in the extinction network in rats [120].”
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- Authors
- Liu, H., Liu, Y., Yu, J., Lai, M., Zhu, H., Sun, A., Chen, W., & Zhou, W.
- Affiliations
- Ningbo University (CN)
- Henan University of Chinese Medicine (CN)
- Corresponding author
- Zhou, Wenhua
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 494
- Issue
- 1
- Pages
- 70-74
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1972156246
- Cited by
- 40
- References
- 34
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- vagus nerve stimulation, heroin addiction, heroin relapse, drug-seeking behavior, reinstatement, nucleus accumbens, FosB, CREB phosphorylation, extinction training, self-administration
- MeSH terms
- Analysis of Variance, Animals, Behavior, Animal, Cues, Heroin, Extinction, Psychological, Heroin Dependence, Male, Narcotics, Nucleus Accumbens, Phosphorylation, Self Administration, Blotting, Western, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Cyclic AMP Response Element-Binding Protein, Rats, Vagus Nerve Stimulation, Drug-Seeking Behavior
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