The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Serotonin 2C receptor alternative splicing in a spinal cord injury model
Abstract
Spinal cord injury can have debilitating consequences, commonly resulting in motor dysfunction below the lesion site and the development of chronic pain syndromes. The serotonin pathway is important for inhibiting noxious stimuli and facilitating motor function after spinal cord injury. The serotonin 2C receptor (5HTR2C) has several characteristic features, and is regulated by the amount of serotonin 2C receptor as well as RNA editing and alternative splicing. In this study, we used a rat model of spinal contusion injury to investigate the relationship between the pain threshold and 5HTR2C alternative splicing. The pain threshold was assessed using mechanical stimulation with von Frey filaments. We then used real-time PCR to examine the RNA levels of 5HTR2C in three sections of the spinal cord: the rostral, injury-core, and caudal positions. On postoperative day 12, the pain threshold in injured rats was significantly reduced compared with sham-operated and naïve rats. The total 5HTR2C levels were significantly lower in injured rats than in naïve rats at all positions, and significantly lower in injured rats compared with sham-operated rats at injury-core and caudal positions. The ratio of exon Vb-skipped nonfunctional 5HTR2C mRNA to total 5HTR2C was significantly higher in injured rats compared with naïve rats at the injury-core and caudal positions, and significantly higher in injured rats compared with sham-operated rats at the caudal position. These results indicate that…
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“Post-transcriptional regulatory mechanisms contribute to orchestrating these gene expression changes [10,11].”
From MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord (2022) · cites this paper as [11]
Citations
Cites
Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762
Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687
Murray, K. C., Nakae, A., Stephens, M. J., Rank, M., D'Amico, J., Harvey, P. J., Li, X., Harris, R. L. W., Ballou, E. W., Anelli, R., et al. (2010) · Nature Medicine · doi:10.1038/nm.2160 · Cited by 407
Self-citationHarvey, P. J., Li, X.-J., Li, Y., & Bennett, D. J. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01088.2005 · Cited by 206
Wang, Q., O'Brien, P. J., Chen, C., Cho, D. C., Murray, J. M., & Nishikura, K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.741290.x · Cited by 197
Serotonin 5‐HT2C Receptor RNA Editing Alters Receptor Basal Activity
Herrick‐Davis, K., Grinde, E., & Niswender, C. M. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.731711.x · Cited by 182
Harvey, P. J., Li, Y., Li, X.-J., & Bennett, D. J. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00335.2005 · Cited by 176
Takahashi, Y., & Nakajima, Y. (1996) · Pain · doi:10.1016/0304-3959(96)03116-8 · Cited by 171
Tansey, K. E., Mehta, S., Hill, D., Foley, N. C., Hsieh, J., Ethans, K. D., Potter, P. J., Baverstock, R., Teasell, R. W., Wolfe, D. L., et al. (2010) · Cited by 152
Li, X., Murray, K., Harvey, P. J., et al. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00995.2006 · Cited by 145
Perrier, J., & Hounsgaard, J. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00753.2002 · Cited by 139
Understanding pain in depression
Stahl, S. M., & Briley, M. (2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.619 · Cited by 129
Roles of serotonin receptor subtypes for the antinociception of 5-HT in the spinal cord of rats
Jeong, C. Y., Choi, J. I., & Yoon, M. H. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.08.048 · Cited by 118
Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene
Flomen, R. H. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh536 · Cited by 111
The Animal Model of Spinal Cord Injury as an Experimental Pain Model
Nakae, A., Nakai, K., Yano, K., Hosokawa, K., Shibata, M., & Mashimo, T. (2011) · BioMed Research International · doi:10.1155/2011/939023 · Cited by 81
Self-citationObata, H., Saito, S., Sakurazawa, S., Sasaki, M., Usui, T., & Goto, F. (2004) · Pain · doi:10.1016/j.pain.2003.12.019 · Cited by 73
Nakai, K., Nakae, A., Oba, S., Mashimo, T., & Ueda, K. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.04.008 · Cited by 39
Self-citationReliability of the Bryce/Ragnarsson Spinal Cord Injury Pain Taxonomy
Bryce, T. N., Dijkers, M. P. J. M., Ragnarsson, K. T., Stein, A., & Chen, B. (2006) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2006.11753865 · Cited by 35
Serotonin2C receptor mRNA editing in neuropathic pain model
Nakae, A., Nakai, K., Tanaka, T., Takashina, M., Hagihira, S., Shibata, M., Ueda, K., & Mashimo, T. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.10.004 · Cited by 26
Self-citationThe role of RNA editing of the serotonin 2C receptor in a rat model of oro‐facial neuropathic pain
Nakae, A., Nakai, K., Tanaka, T., Hagihira, S., Shibata, M., Ueda, K., & Mashimo, T. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06205.x · Cited by 17
Self-citationSerotonin 2C Receptor Alternative Splicing in a Rat Model of Orofacial Neuropathic Pain
Nakae, A., Nakai, K., Tanaka, T., Hosokawa, K., & Mashimo, T. (2012) · Neuroscience & Medicine · doi:10.4236/nm.2012.31011 · Cited by 1
Self-citation
Cited by
Maza, R. M., Barreda-Manso, M. A., Reigada, D., Silván, Á., Muñoz-Galdeano, T., Soto, A., del Águila, Á., & Nieto-Díaz, M. (2022) · Biomedicines · doi:10.3390/biomedicines10071559 · Cited by 12
Metadata
- Authors
- Nakae, A., Nakai, K., Tanaka, T., Hosokawa, K., & Mashimo, T.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 532
- Pages
- 49-54
- ISSN
- 0304-3940
- Cited by
- 14
- References
- 21
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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