Wistar Audiogenic Rats (WAR) exhibit altered levels of cytokines and brain-derived neurotrophic factor following audiogenic seizures
Abstract
Increasing body of evidence suggests that inflammatory and neurotrophic factors might be important for epileptogenesis. Most animal studies demonstrated altered levels of these mediators in drug-induced models of seizures and epilepsy. In the present study, we investigated the production of cytokines and a neurotrophin in the brain of Wistar Audiogenic Rats (WAR), a genetic model of epilepsy, stimulated with high-intensity sound. Four hours after stimulation, animals were decapitated and the hippocampus, inferior colliculus, striatum and cortex were removed for evaluation of the levels of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and brain derived neurotrophic factor (BDNF). All the cytokines and BDNF levels were increased in the cortex. Increased levels of TNF-α and IL-6 were also observed in the striatum. Finally, TNF-α also increased in the inferior colliculus after the seizures induced by high-intensity sound. Although different studies have demonstrated that the levels of cytokines and BDNF increase in animal models of epilepsy induced by chemical stimuli, we provided here evidence that these mediators are also increased in WAR, a genetic model of epilepsy. Thus, the observed increase in these mediators might be involved in the pathophysiology of epilepsy.
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Seizures increase hippocampal and cortical BDNF protein levels in animal models of epilepsy.
“Seizures also increased hippocampal and cortical BDNF protein levels in animal model of epilepsy [181–183].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [183]
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- Authors
- de Souza Bernardino, T. C., Teixeira, A. L., Miranda, A. S., Guidine, P. M., Rezende, G., Doretto, M. C., Castro, G. P., Drummond, L., Moraes, M. F. D., Tito, P. A. L., de Oliveira, A. C. P., & Reis, H. J.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Corresponding author
- Reis, Helton José
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 597
- Pages
- 154-158
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1967695623
- Cited by
- 18
- References
- 43
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 1
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- Wistar audiogenic rat, audiogenic seizures, genetic epilepsy model, cytokines, brain-derived neurotrophic factor, IL-1β, interleukin-6, TNF-α, neuroinflammation, epileptogenesis, inferior colliculus, striatum, cortex, hippocampus
- MeSH terms
- Acoustic Stimulation, Animals, Brain, Male, Seizures, Tumor Necrosis Factor-alpha, Cytokines, Rats, Wistar, Brain-Derived Neurotrophic Factor, Interleukin-1beta
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