Evaluating the relationship between reelin gene variants (rs7341475 and rs262355) and schizophrenia: A meta-analysis
Abstract
Studies have suggested that reelin (RELN) polymorphism was associated with the susceptibility of schizophrenia (SZ), but the results remained controversial. Thus, we conducted this meta-analysis to determine whether RELN variants (rs7341475 and rs262355) were associated with SZ risk. Studies were identified through retrieving Web of Science, PubMed and Embase databases from inception to May 2015. The genotype data were extracted to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). For rs7341475, five studies with 4741 SZ patients and 10075 controls are included and the results indicate that carriage of A allele is associated with decreased SZ risk in dominant genetic model (OR=0.90, 95%CI=0.83-0.98) and additive model (OR=0.90, 95% CI=0.84-0.97). Subgroup analysis indicates that the association between rs7341475 and SZ is only significant in Caucasian. For rs262355, four studies with 2017 SZ patients and 3274 controls are included, the results demonstrate that carriage of A allele is associated with increased risk of SZ only in Caucasian (dominant model: OR=1.17, 95%CI=1.01-1.37; additive model OR=1.13, 95%CI=1.02-1.27). This meta-analysis suggests that rs7341475 (A/G) and rs262355 (A/T) polymorphisms in RELN gene are inversely associated with SZ risk.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Axonal guidance and reelin signaling are important pathways for nervous system development and have been implicated in neuropsychiatric disorders such as bipolar, SCZ, and ADHD.
“Axonal guidance and reelin signaling are important pathways for nervous system development and have been implicated in neuropsychiatric disorders such as bipolar, SCZ, and ADHD [64–68]”
From An integrated analysis of genes and functional pathways for aggression in human and rodent models (2019) · cites this paper as [66]
Cites
(2014) · Medical Entomology and Zoology · Cited by 17,633 · see citing works
van Os, J., & Kapur, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60995-8 · Cited by 1,971 · see citing works
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Multicenter Genetic Studies of Schizophrenia Consortium, Ripke, S., Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium 2, O'Dushlaine, C., Chambert, K., Moran, J. L., Kähler, A. K., Akterin, S., Bergen, S. E., et al. (2013) · Nature Genetics · doi:10.1038/ng.2742 · Cited by 1,496 · see citing works
Shifman, S., Johannesson, M., Bronstein, M., Chen, S. X., Collier, D. A., Craddock, N. J., Kendler, K. S., Li, T., O’Donovan, M. C., O’Neill, F. A., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040028 · Cited by 345 · see citing works
The involvement of Reelin in neurodevelopmental disorders
Folsom, T. D., & Fatemi, S. H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.015 · Cited by 275 · see citing works
McNeil, T. F., Cantor‐Graae, E., & Weinberger, D. R. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.2.203 · Cited by 206 · see citing works
Association of Reelin gene polymorphisms with autism
Serajee, F., Zhong, H., & Huq, A. H. M. M. (2005) · Genomics · doi:10.1016/j.ygeno.2005.09.008 · Cited by 124 · see citing works
Kähler, A. K., Djurovic, S., Kulle, B., Jönsson, E. G., Agartz, I., Hall, H., Opjordsmoen, S., Jakobsen, K. D., Hansen, T. F., Melle, I. S., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30726 · Cited by 118 · see citing works
The Genetic Variation of RELN Expression in Schizophrenia and Bipolar Disorder
Ovadia, G., & Shifman, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019955 · Cited by 79 · see citing works
Wedenoja, J., Tuulio‐Henriksson, A., Suvisaari, J., Loukola, A., Paunio, T., Partonen, T., Varilo, T., Lönnqvist, J. K., & Peltonen, L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.026 · Cited by 64 · see citing works
Kupferman, J. V., Basu, J., Russo, M. J., Guevarra, J., Cheung, S. K., & Siegelbaum, S. A. (2014) · Cell · doi:10.1016/j.cell.2014.07.035 · Cited by 62 · see citing works
van Haren, N. E. M., Rijsdijk, F. V., Schnack, H. G., Picchioni, M., Toulopoulou, T., Weisbrod, M., Sauer, H., van Erp, T. G., Cannon, T. D., HUTTUNEN, M. O., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.010 · Cited by 59 · see citing works
Liu, Y., Chen, P.-L., McGrath, J. A., Wolyniec, P. S., Fallin, M. D., Nestadt, G., Liang, K., Pulver, A. E., Valle, D. L., & Avramopoulos, D. (2010) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32833a220b · Cited by 47 · see citing works
Goldberger, C., Gourion, D., Leroy, S., Schürhoff, F., Bourdel, M., Leboyer, M., & Krebs, M. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30191 · Cited by 46 · see citing works
Decreased Reelin Expression in the Left Prefrontal Cortex (BA9) in Chronic Schizophrenia Patients
Habl, G., Schmitt, A., Zink, M., von Wilmsdorff, M., Yeganeh-Doost, P., Jatzko, A., Schneider-Axmann, T., Bauer, M., & Falkai, P. (2012) · Neuropsychobiology · doi:10.1159/000337129 · Cited by 42 · see citing works
Akahane, A., Kunugi, H., Tanaka, H. O., & Nanko, S. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00398-x · Cited by 38 · see citing works
Li, M., Luo, X., Xiao, X., Shi, L., Liu, X., Yin, L.-D., Ma, X., Yang, S.-Y., Pu, X., Yu, J. S., et al. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.587891 · Cited by 34 · see citing works
Association study of RELN polymorphisms with schizophrenia in Han Chinese population
Li, W., Song, X., Zhang, H., Yang, Y., Jiang, C., Xiao, B., Li, W., Yang, G., Zhao, J., Guo, W., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.04.007 · Cited by 33 · see citing works
Self-citationKuang, W. J., Sun, R., Zhu, Y., & Li, S. B. (2011) · Genetics and Molecular Research · doi:10.4238/vol10-3gmr1343 · Cited by 24 · see citing works
Association of SLC18A1, TPH1, and RELN gene polymorphisms with risk of paranoid schizophrenia
Galaktionova, D. Y., Эмировна, Г. А., Хуснутдинова, Э. К., & Nasedkina, T. V. (2014) · Molecular Biology · doi:10.1134/s0026893314030042 · Cited by 20 · see citing works
Antoniades, D., Katopodi, T., Pappa, S., Lampropoulos, A., Konsta, V., Frydas, E., Mpalogiannis, S., & Hatzistilianou, M. N. (2011) · PubMed · Cited by 19 · see citing works
Galaktionova, D. I., Гареева, А. Э., Хуснутдинова, Э. К., & Tv, N. (2014) · PubMed · Cited by 14 · see citing works
[Association of RELN SNP rs7341475 with schizophrenia in the Chinese population].
Liu, X., Li, M., Yang, S.-Y., Su, B., & Yin, L.-D. (2011) · PubMed · doi:10.3724/sp.j.1141.2011.05499 · Cited by 8 · see citing works
An Evolutionary Approach Reveals New Clues toward Understanding the Roots of Schizophrenia
Caspermeyer, J. J. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv066 · Cited by 4 · see citing works
Turning a Vole into a Mighty Rodent
Caspermeyer, J. J. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv065 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 26 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Reelin and neuropsychiatric disorders
Ishii, K., Kubo, K.-I., & Nakajima, K. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00229 · Cited by 185 · see citing works
Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia
Mohammadi, A., Rashidi, E., & Amooeian, V. G. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.04.036 · Cited by 115 · see citing works
An integrated analysis of genes and functional pathways for aggression in human and rodent models
Zhang-James, Y., Fernàndez-Castillo, N., Hess, J. L., Malki, K., Glatt, S. J., Cormand, B., & Faraone, S. V. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0068-7 · Cited by 98 · see citing works
Murphy, E., & Benítez‐Burraco, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.029 · Cited by 64 · see citing works
Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia
Nabil Fikri, R. M., Norlelawati, A. T., Nour El-Huda, A. R., Hanisah, M. N., Kartini, A., Norsidah, K., & Nor Zamzila, A. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.12.020 · Cited by 61 · see citing works
DNA Methylation and Schizophrenia: Current Literature and Future Perspective
Magwai, T., Shangase, K. B., Oginga, F. O., Chiliza, B., Mpofana, T., & Xulu, K. R. (2021) · Cells · doi:10.3390/cells10112890 · Cited by 62 · see citing works
Bridging the Gap between Genes and Language Deficits in Schizophrenia: An Oscillopathic Approach
Murphy, E., & Benítez‐Burraco, A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00422 · Cited by 52 · see citing works
González‐Castro, T. B., Hernández‐Díaz, Y., Juárez‐Rojop, I. E., López‐Narváez, M. L., Tovilla‐Zárate, C. A., Mendoza, A. D. G., & Alpuin-Reyes, M. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0114-z · Cited by 43 · see citing works
Daghestani, M. H., Selim, M. E., Abd‐Elhakim, Y. M., Said, E. N., El-Hameed, N. E. A., Khalil, S. R., & El-Tawil, O. S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.034 · Cited by 39 · see citing works
Toward the Language Oscillogenome
Murphy, E., & Benítez‐Burraco, A. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01999 · Cited by 30 · see citing works
The Candidate Schizophrenia Risk Gene DGCR2 Regulates Early Steps of Corticogenesis
Molinard‐Chenu, A., & Dayer, A. G. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.015 · Cited by 28 · see citing works
Reelin Signaling Controls the Preference for Social Novelty in Zebrafish
Vecchia, E. D., Donato, V. D., Young, A. M. J., Bene, F. D., & Norton, W. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00214 · Cited by 24 · see citing works
Sawahata, M., Mori, D., Arioka, Y., Kubo, H., Kushima, I., Kitagawa, K., Sobue, A., Shishido, E., Sekiguchi, M., Kodama, A., et al. (2020) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12993 · Cited by 22 · see citing works
Female gender specific association of the Reelin (RELN) gene rs7341475 variant with schizophrenia
Sözügüzel, M. D., Sazcı, A., & Yıldız, M. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04803-w · Cited by 20 · see citing works
Guo, J., Riley, K. W., Durham, T., Margolis, A. E., Wang, S., Perera, F. P., & Herbstman, J. B. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.871820 · Cited by 15 · see citing works
Marzan, S., Aziz, M. A., & Islam, M. S. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01696-4 · Cited by 15 · see citing works
Zebrafish Models of Autosomal Dominant Ataxias
Quelle‐Regaldie, A., Sobrido‐Cameán, D., Barreiro‐Iglesias, A., Sobrido, M. J., & Sanchez, L. E. (2021) · Cells · doi:10.3390/cells10020421 · Cited by 15 · see citing works
Nawa, Y., Kimura, H., Mori, D., Kato, H., Toyama, M., Furuta, S., Yu, Y., Ishizuka, K., Kushima, I., Aleksić, B., et al. (2020) · Human Genome Variation · doi:10.1038/s41439-020-00125-7 · Cited by 14 · see citing works
Reelin Signaling and Synaptic Plasticity in Schizophrenia
Markiewicz, R., Markiewicz-Gospodarek, A., Borowski, B., Trubalski, M., & Łoza, B. (2023) · Brain Sciences · doi:10.3390/brainsci13121704 · Cited by 12 · see citing works
Wu, C. J., Huang, B. E., Chen, G., Lovenberg, T. W., Pocalyko, D. J., & Yao, X. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00396 · Cited by 12 · see citing works
Escudero, B., Moya, M., López-Valencia, L., Árias, F., & Orío, L. (2023) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyad034 · Cited by 9 · see citing works
Yin, J., Lu, Y., Yu, S., Dai, Z., Zhang, F., & Yuan, J. (2020) · Hereditas · doi:10.1186/s41065-020-00158-6 · Cited by 11 · see citing works
Ping, J., Wan, J., Luo, J., Du, B., Liu, X., Jiang, T., & Zhang, J. (2024) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10316 · Cited by 1 · see citing works
Expression Profiling of Reelin (RELN) Gene in Patients With Schizophrenia from North Karnataka
Dongre, N., Shattar, C., Ramdurg, S. I., & Kadakol, G. S. (2025) · Cureus · doi:10.7759/cureus.76850 · Cited by 1 · see citing works
RELN rs7341475 Associates with Brain Structure in Japanese Healthy Females
Yamaguchi, R., Matsudaira, I. Y., Takeuchi, H., Imanishi, T., Kimura, R., Tomita, H., Kawashima, R., & Taki, Y. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.05.007 · Cited by 1 · see citing works
DNA methylation and schizophrenia – the role in pathogenesis and the diagnosis of the disease
Płaza, O., & Szulc, A. (2022) · Pharmacotherapy in Psychiatry and Neurology · doi:10.5114/fpn.2022.117702 · Cited by 1 · see citing works
Understanding the risk and functional importance of schizophrenia genetic factors
Cheah, S.-Y. (2016) · Queensland University of Technology · doi:10.5204/thesis.eprints.101340
Characterization of Neural Cells Derived from Reelin-deficient Schizophrenic Patient iPS Cells
Roberts, N. (2018) · Journal of International Crisis and Risk Communication Research
Mental Disorders and DNA Methylation
Örenay-Boyacıoğlu, S., Boyacıoğlu, O., & Döndü, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_148-1
Mental Disorders and DNA Methylation
Örenay-Boyacıoğlu, S., Boyacioglu, O., & Döndü, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_148
Zhu, Y., Kitagawa, K., Mori, D., Matsuzaki, T., Nagai, T., Nabeshima, T., Takemoto‐Kimura, S., Ikesue, H., Ozaki, N., Mizoguchi, H., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178407
- Authors
- Li, W., Guo, X., & Xiao, S.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Corresponding author
- Xiao, Shifu
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 609
- Pages
- 42-47
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2177553103
- Cited by
- 31
- References
- 26
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 5
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81201030)
- China Science and Technology Ministry National Pillar Program (2009BAI77B03)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- reelin, RELN gene, schizophrenia, genetic polymorphism, genetic susceptibility, allele association, Caucasian population
- MeSH terms
- Reelin Protein, Humans, Nerve Tissue Proteins, Polymorphism, Genetic, Risk, Schizophrenia, Serine Endopeptidases, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Genetic Predisposition to Disease, Genetic Association Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
