CoChat
Sign Up
Cited by 30

The DOI matches its Crossref record.

MicroRNA-128-3p Alleviates Neuropathic Pain Through Targeting ZEB1

Zhang, Xianlong, Zhang, Yang, Cai, Wei, Liu, Yan, Liu, Hailin, Zhang, Zhijie, Su, Zhen·2020·Neuroscience Letters
DOI 10.1016/j.neulet.2020.134946
Open this paper in CoChat — free account

Abstract

Neuropathic pain is defined as a chronic pain. It could be resulted from a lesion of nervous systems. MicroRNAs have been reported to modulate multiple genes and pathways in neuropathic pain and neuroinflammation. Therefore, identifying the potential expression patterns of microRNAs under neuropathic pain conditions is significant. miR-128-3p has been identified in many cancers. But, its biological role in neuropathic pain progression remains poorly known. Currently, we aimed to explore the possible functions of miR-128-3p in the modulation of neuropathic pain. We displayed in the CCI rats, miR-128-3p was greatly down-regulated in the spinal cord tissues and the isolated microglias. Subsequently, LV-miR-128-3p could attenuate CCI-triggered mechanical allodynia and thermal hyperalgesia. Meanwhile, some common pro-inflammatory cytokines were significantly reduced while anti-inflammatory cytokine IL-10 was increased by miR-128-3p. Here, in the current investigation, by utilizing dual-luciferase reporter assays, ZEB1 was proved as a direct target of miR-128-3p. LV-miR-128-3p significantly repressed ZEB1 expression in microglia of CCI rats. Moreover, ZEB1 was reported to be increased in CCI rats. miR-128-3p rescued the effects of ZEB1 on neuropathic pain progression via inhibiting neuroinflammation. Taken these together, we implied miR-128-3p alleviated the progression of neuropathic pain via modulating ZEB1.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.neulet.2020.134946

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 32

  1. Bao, 2018, MiR-28-5p relieves neuropathic pain by targeting Zeb1 in CCI rat models, Journal of cellular biochemistry, 119, 8555, 10.1002/jcb.27096 · DOI
  2. Browne, 2010, ZEB proteins link cell motility with cell cycle control and cell survival in cancer, Cell cycle, 9, 886, 10.4161/cc.9.5.10839 · DOI
  3. Caramel, 2018, Pleiotropic Roles for ZEB1 in Cancer, Cancer research, 78, 30, 10.1158/0008-5472.CAN-17-2476 · DOI
  4. Cieply, 2013, Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2, Cancer research, 73, 6299, 10.1158/0008-5472.CAN-12-4082 · DOI
  5. Dalm, 2015, Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats, Pain, 156, 2562, 10.1097/j.pain.0000000000000365 · DOI
  6. Diaz, 2016, F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check, Seminars in cancer biology, 36, 71, 10.1016/j.semcancer.2015.10.003 · DOI
  7. Ellis, 2013, Neuroinflammation and the generation of neuropathic pain, British journal of anaesthesia, 111, 26, 10.1093/bja/aet128 · DOI
  8. Fernandes, 2018, Cellular and molecular mechanisms driving neuropathic pain: recent advancements and challenges, Expert opinion on therapeutic targets, 22, 131, 10.1080/14728222.2018.1420781 · DOI
  9. He, 2014, Anti-allodynic effects of obtusifolin and gluco-obtusifolin against inflammatory and neuropathic pain, Biological & pharmaceutical bulletin, 37, 1606, 10.1248/bpb.c14-00307 · DOI
  10. Ji, 2018, MiR-150 alleviates neuropathic pain via inhibiting toll-like receptor 5, Journal of cellular biochemistry, 119, 1017, 10.1002/jcb.26269 · DOI
  11. Jiangpan, 2016, Emerging Role of microRNA in Neuropathic Pain, Current drug metabolism, 17, 336, 10.2174/1389200216666151015113400 · DOI
  12. Li, 2016, Downregulation of microRNA-218 relieves neuropathic pain by regulating suppressor of cytokine signaling 3, International journal of molecular medicine, 37, 851, 10.3892/ijmm.2016.2455 · DOI
  13. Lopez-Gonzalez, 2017, MicroRNA and chronic pain: From mechanisms to therapeutic potential, Pharmacology & therapeutics, 180, 1, 10.1016/j.pharmthera.2017.06.001 · DOI
  14. Mohr, 2015, Overview of microRNA biology, Seminars in liver disease, 35, 3, 10.1055/s-0034-1397344 · DOI
  15. Peinado, 2007, Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nature reviews, Cancer, 7, 415
  16. Postigo, 2003, Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins, The EMBO journal, 22, 2453, 10.1093/emboj/cdg226 · DOI
  17. Sacerdote, 2013, Cytokine modulation is necessary for efficacious treatment of experimental neuropathic pain, Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 8, 202, 10.1007/s11481-012-9428-2 · DOI
  18. Sakai, 2014, Emerging roles of microRNAs in chronic pain, Neurochemistry international, 77, 58, 10.1016/j.neuint.2014.05.010 · DOI
  19. Sakai, 2015, microRNA and Pain, Advances in experimental medicine and biology, 888, 17, 10.1007/978-3-319-22671-2_3 · DOI
  20. Shi, 2018, MiR-145 ameliorates neuropathic pain via inhibiting inflammatory responses and mTOR signaling pathway by targeting Akt3 in a rat model, Neuroscience research, 134, 10, 10.1016/j.neures.2017.11.006 · DOI
  21. Sun, 2017, Overexpression of miR-206 ameliorates chronic constriction injury-induced neuropathic pain in rats via the MEK/ERK pathway by targeting brain-derived neurotrophic factor, Neuroscience letters, 646, 68, 10.1016/j.neulet.2016.12.047 · DOI
  22. Tan, 2013, MicroRNA-based therapy in pain medicine: Current progress and future prospects, Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 51, 171, 10.1016/j.aat.2013.11.001 · DOI
  23. Xia, 2018, Decreased MiR-128-3p alleviates the progression of rheumatoid arthritis by up-regulating the expression of TNFAIP3, Bioscience reports, 38, 10.1042/BSR20180540 · DOI
  24. Xie, 2017, MicroRNA-183 Suppresses Neuropathic Pain and Expression of AMPA Receptors by Targeting mTOR/VEGF Signaling Pathway, Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology, 41, 181
  25. Yan, 2017, MicroRNA-93 alleviates neuropathic pain through targeting signal transducer and activator of transcription 3, International immunopharmacology, 46, 156, 10.1016/j.intimp.2017.01.027 · DOI
  26. Yan, 2018, XIST accelerates neuropathic pain progression through regulation of miR-150 and ZEB1 in CCI rat models, Journal of cellular physiology, 233, 6098, 10.1002/jcp.26453 · DOI
  27. Yan, 2018, Inhibition of miR-200b/miR-429 contributes to neuropathic pain development through targeting zinc finger E box binding protein-1, Journal of cellular physiology, 233, 4815, 10.1002/jcp.26284 · DOI
  28. Zhang, 2015, ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance, Cell cycle, 14, 481, 10.1080/15384101.2015.1006048 · DOI · Paper page
  29. Zhang, 2018, MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1, International journal of molecular medicine, 41, 501
  30. Zhao, 2018, Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer, Acta biochimica et biophysica Sinica, 50, 171, 10.1093/abbs/gmx132 · DOI
  31. Zhao, 2015, miR-128 modulates hepatocellular carcinoma by inhibition of ITGA2 and ITGA5 expression, American journal of translational research, 7, 1564
  32. Zhou, 2015, miR-128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF-C upregulation, Oncology letters, 10, 3183, 10.3892/ol.2015.3689 · DOI

Cited by

Sorted by citations

See all 30

Metadata

Authors
Zhang, X., Zhang, Y., Cai, W., Liu, Y., Liu, H., Zhang, Z., & Su, Z.
ORCID
Su, Zhen
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2020-06
Volume
729
Pages
134946
ISSN
0304-3940
DOI
10.1016/j.neulet.2020.134946
Cited by
30
References
0
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: MicroRNA-128-3p Alleviates Neuropathic Pain Through Targeting ZEB1. https://app.cochat.ai/papers/10.1016/j.neulet.2020.134946
The paper
Zhang, X., Zhang, Y., Cai, W., Liu, Y., Liu, H., Zhang, Z., & Su, Z. (2020). MicroRNA-128-3p Alleviates Neuropathic Pain Through Targeting ZEB1. Neuroscience Letters. https://doi.org/10.1016/j.neulet.2020.134946