The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
Abstract
Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null mutation of gene coding histamine H1 or H2 receptor in order to clarify the role of these receptors in learning and memory processes. Learning and memory were evaluated by several behavioral tasks including object recognition, Barnes maze and fear conditioning. These behavioral tasks are highly dependent on the function of prefrontal cortex, hippocampus or amygdala. Object recognition and Barnes maze performance were significantly impaired in both H1 receptor gene knockout (H1KO) and H2 receptor gene knockout (H2KO) mice when compared to the respective wild-type (WT) mice. Conversely, both H1KO and H2KO mice showed better auditory and contextual freezing acquisition than their respective WT mice. Furthermore, we also examined long-term potentiation (LTP) in the CA1 area of hippocampus in H1KO and H2KO mice and their respective WT mice. LTP in the CA1 area of hippocampus was significantly reduced in both H1KO and H2KO mice when compared with their respective WT mice. In conclusion, our results demonstrate that both H1 and H2 receptors are involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact.
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“In histamine H1-R and H2-R knockout mice, LTP in the hippocampus CA1 area was decreased together with impairment of NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Dai et al., 2007
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“…difference was observed between the groups even in the subgroup with high fatigue levels, the mean score showed improvement in the L-histidine group (L-histidine group, –16.4 [20.9]; placebo group, –6.58 [20.7], p = 0.238, with a lower score indicating a state of stronger “clear thinking”).”
Influential
Metadata
- Authors
- Dai, H., Kaneko, K., Kato, H., Fujii, S., Jing, Y., Xu, A., Sakurai, E., Kato, M., Okamura, N., Kuramasu, A., & Yanai, K.
- Affiliations
- Tohoku University (JP)
- Yamagata University (JP)
- Corresponding author
- Yanai, Kazuhiko
- ORCID
- Venue
- Neuroscience Research
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 57
- Issue
- 2
- Pages
- 306-313
- ISSN
- 0168-0102 (ISSN-L)
- OpenAlex
- W2047066043
- Cited by
- 136
- References
- 50
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 11 · 2013: 12 · 2012: 8
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- histamine H1 receptor, histamine H2 receptor, knockout mice, learning and memory, synaptic plasticity, long-term potentiation, hippocampal CA1, object recognition, Barnes maze, fear conditioning, prefrontal cortex, amygdala, cognitive impairment
- MeSH terms
- Analysis of Variance, Animals, Cognition Disorders, Conditioning, Psychological, Fear, Hippocampus, Neuropsychological Tests, Receptors, Histamine H1, Receptors, Histamine H2, Long-Term Potentiation, Mice, Knockout, Maze Learning, Mice
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