Subtype specific roles of serotonin receptors in the spine formation of cortical neurons in vitro
Open accessAbstract
Dendritic spines are postsynaptic structures which are formed from filopodia. We examined roles of serotonin (5-HT) receptors in the spine formation. Embryonic rat cortical neurons were cultured for 10 or 14 days and treated by 5-HT receptor agonists for 24 h. At 11 days in vitro, 5-HT(1A) agonist increased filopodia density, whereas 5-HT(2A/2C) agonist increased the density of puncta and spines. At 15 days in vitro, 5-HT(1A) agonist decreased the density of puncta and spines, whereas 5-HT(2A/2C) agonist decreased filopodia density with increase of spines. In conclusion, the present study shows 5-HT receptors have subtype-specific effects on the spine formation.
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DOI increases synaptic puncta in cultured cortical neurons.
“DOI, one of the more readily accessible psychedelics to researchers, has been shown to increase dendritic growth (Persico et al., 2006;Ohtani et al., 2014;Ly, Greb et al., 2018;Ly et al., 2021), synaptic puncta, spine density (Yoshida et al., 2011;Ly et al., 2018), and spine size (Jones et al., 2009) in cultured cortical neurons.”
From Psychedelics and Neural Plasticity: Therapeutic Implications (2022) · cites this paper as Yoshida et al., 2011
DOI increases spine density in cultured cortical neurons.
“DOI, one of the more readily accessible psychedelics to researchers, has been shown to increase dendritic growth (Persico et al., 2006;Ohtani et al., 2014;Ly, Greb et al., 2018;Ly et al., 2021), synaptic puncta, spine density (Yoshida et al., 2011;Ly et al., 2018), and spine size (Jones et al., 2009) in cultured cortical neurons.”
From Psychedelics and Neural Plasticity: Therapeutic Implications (2022) · cites this paper as Yoshida et al., 2011
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Jones, K. A., Srivastava, D. P., Allen, J. A., Strachan, R. T., Roth, B. L., & Penzes, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905884106 · Cited by 226 · see citing works
Embryonic depletion of serotonin affects cortical development
Vitalis, T., Cases, O., Passemard, S., Callebert, J., & Parnavelas, J. G. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05661.x · Cited by 155 · see citing works
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Psychedelics and Neural Plasticity: Therapeutic Implications
Grieco, S. F., Castrén, E., Knudsen, G. M., Kwan, A. C., Olson, D. E., Zuo, Y., Holmes, T. C., & Xu, X. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.1121-22.2022 · Cited by 82 · see citing works
“…psychedelics to researchers, has been shown to increase dendritic growth (Persico et al., 2006; Ohtani et al., 2014; Ly, Greb et al., 2018; Ly et al., 2021), synaptic puncta, spine density (Yoshida et al., 2011; Ly et al., 2018), and spine size (Jones et al., 2009) in cultured cortical neurons.”
Xu, C., Ma, X.-M., Chen, H.-B., Zhou, M.-H., Qiao, H., & An, S.-C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.020 · Cited by 34 · see citing works
- Authors
- Yoshida, H., Kanamaru, C., Ohtani, A., Li, F., Senzaki, K., & Shiga, T.
- Affiliations
- University of Tsukuba (JP)
- Corresponding author
- Shiga, Takashi
- Venue
- Neuroscience Research
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 71
- Issue
- 3
- Pages
- 311-314
- ISSN
- 0168-0102 (ISSN-L)
- OpenAlex
- W1967868449
- Cited by
- 33
- References
- 2
- Citations by year
- 2026: 4 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- Locations
- Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Terrestrial Environment Research Center (University of Tsukuba) (publishedVersion)
- Institutional Repositories DataBase (IRDB) (acceptedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Lupus Research Institute
- Japan Chemical Industry Association
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- serotonin receptors, dendritic spine formation, filopodia, 5-HT1A receptor, 5-HT2A/2C receptors, cortical neurons, postsynaptic structures, receptor subtype specificity, serotonin receptor agonists
- MeSH terms
- Animals, Cell Differentiation, Cerebral Cortex, Neurons, Receptors, Serotonin, Rats, Wistar, Receptor, Serotonin, 5-HT1A, Receptor, Serotonin, 5-HT2A, Receptor, Serotonin, 5-HT2C, Dendritic Spines, Rats, Neurogenesis, Primary Cell Culture
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