Rapid modulation of spine morphology by the 5-HT 2A serotonin receptor through kalirin-7 signaling

Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior

González-Maeso, J., Weisstaub, N. V., Zhou, M., Chan, P., Ivic, L., Ang, R., Lira, A., Bradley-Moore, M., Ge, Y., Zhou, Q., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.008 · Cited by 925 · see citing works

Balancing Structure and Function at Hippocampal Dendritic Spines

Bourne, J. N., & Harris, K. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125646 · Cited by 916 · see citing works

Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors

Pompeiano, M., Palacios, J. M., & Mengod, G. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90223-2 · Cited by 870 · see citing works

Anatomical and Physiological Plasticity of Dendritic Spines

Alvarez, V. A., & Sabatini, B. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094222 · Cited by 629 · see citing works

5-Hydroxytryptamine _2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites

Jakab, R. L., & Goldman-Rakic, P. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.735 · Cited by 536 · see citing works

Rapid Induction of Dendritic Spine Morphogenesis by trans-Synaptic EphrinB-EphB Receptor Activation of the Rho-GEF Kalirin

Penzes, P., Beeser, A., Chernoff, J., Schiller, M. R., Eipper, B. A., Mains, R. E., & Huganir, R. L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01168-6 · Cited by 466 · see citing works

Cortical 5-HT 2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice

Weisstaub, N., Zhou, M., Lira, A., Lambe, E. K., González‐Maeso, J., Hornung, J., Sibille, E. L., Underwood, M. D., Itohara, S., Dauer, W. T., et al. (2006) · Science · doi:10.1126/science.1123432 · Cited by 425 · see citing works

The Neuronal Rho-GEF Kalirin-7 Interacts with PDZ Domain–Containing Proteins and Regulates Dendritic Morphogenesis

Penzes, P., Johnson, R. C., Sattler, R., Zhang, X., Huganir, R. L., Kambampati, V., Mains, R. E., & Eipper, B. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00193-3 · Cited by 378 · see citing works

Kalirin-7 Controls Activity-Dependent Structural and Functional Plasticity of Dendritic Spines

Xie, Z., Srivastava, D. P., Photowala, H., Kai, L., Cahill, M. E., Woolfrey, K. M., Shum, C. Y., Surmeier, D. J., & Penzes, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.005 · Cited by 373 · see citing works

Paradoxical trafficking and regulation of 5-HT2A receptors by agonists and antagonists

Gray, J. A. B., & Roth, B. L. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00623-2 · Cited by 296 · see citing works

SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation

Krapivinsky, G., Medina, I., Krapivinsky, L., Gapon, S., & Clapham, D. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.003 · Cited by 287 · see citing works

Short‐term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus

Hajszán, T., MacLusky, N. J., & Leranth, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03968.x · Cited by 239 · see citing works

Activation of Serotonin Receptors Modulates Synaptic Transmission in Rat Cerebral Cortex

Zhou, F.-M., & Hablitz, J. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.6.2989 · Cited by 238 · see citing works

Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia

Hill, J. J., Hashimoto, T., & Lewis, D. A. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001792 · Cited by 228 · see citing works

Molecular Targets for Treating Cognitive Dysfunction in Schizophrenia

Gray, J. A., & Roth, B. L. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm074 · Cited by 225 · see citing works

5-HT2A receptor or α1-adrenoceptor activation induces excitatory postsynaptic currents in layer V pyramidal cells of the medial prefrontal cortex

Marek, G. J., & Aghajanian, G. K. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00945-5 · Cited by 221 · see citing works

Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex

Miner, L. A. H., Backstrom, J. R., Sanders-Bush, E., & Sesack, S. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00580-8 · Cited by 216 · see citing works

霊長類大脳皮質の5‐ヒドロキシトリプタミン2Aセロトニン受容体 錐体細胞先端樹状突起での幻覚剤及び抗精神病剤の作用部位

Jakab, R. L., & Goldman‐Rakic, P. S. (1998) · Cited by 182 · see citing works

Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease

Blanpied, T. A., & Ehlers, M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.006 · Cited by 179 · see citing works

A Direct Interaction of PSD-95 with 5-HT2A Serotonin Receptors Regulates Receptor Trafficking and Signal Transduction

Xia, Z., Gray, J. A., Compton-Toth, B. A., & Roth, B. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301905200 · Cited by 178 · see citing works

The Serotonin 5-HT2A and 5-HT2C Receptors Interact with Specific Sets of PDZ Proteins

Bécamel, C., Gavarini, S., Chanrion, B., Alonso, G., Galéotti, N., Dumuis, A., Bockaert, J., & Marin, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312106200 · Cited by 170 · see citing works

Interaction of Serotonin 5-Hydroxytryptamine Type 2C Receptors with PDZ10 of the Multi-PDZ Domain Protein MUPP1

Bécamel, C., Figge, A., Poliak, S., Dumuis, A., Peles, E., Bockaert, J., Lübbert, H., & Ullmer, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008089200 · Cited by 169 · see citing works

Temporal and Spatial Distribution of Activated Pak1 in Fibroblasts

Sells, M. A., Pfaff, A., & Chernoff, J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.7.1449 · Cited by 160 · see citing works

Dendritic spine dynamics--a key role for kalirin-7

Penzes, P., & Jones, K. A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.001 · Cited by 157 · see citing works

Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity

Srivastava, D. P., Woolfrey, K. M., Jones, K. A., Shum, C. Y., Lash, L. L., Swanson, G. T., & Penzes, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801581105 · Cited by 155 · see citing works

Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB

Marta Ribasés, A., Ramos‐Quiroga, J. A., Amaia Hervas, G., Bosch, R., Bielsa, A., Gastaminza, X., Artigas-Pallarés, J., Rodriguez-Ben, S., Estivill, X., Casas, M., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002100 · Cited by 154 · see citing works

PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors

Abbas, A. I., Yadav, P. N., Yao, W.-D., Arbuckle, M. I., Grant, S. G. N., Caron, M. G., & Roth, B. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1090-09.2009 · Cited by 137 · see citing works

Developmental regulation of 5-HT2 and 5-HT1C mRNA and receptor levels

Roth, B. L., Hamblin, M. W., & Ciaranello, R. D. (1991) · Developmental Brain Research · doi:10.1016/0165-3806(91)90236-c · Cited by 123 · see citing works

Mpdz is a quantitative trait gene for drug withdrawal seizures

Shirley, R. L., Walter, N. A. R., Reilly, M. T., Fehr, C., & Buck, K. J. (2004) · Nature Neuroscience · doi:10.1038/nn1271 · Cited by 122 · see citing works

GPCR-interacting proteins (GIPs): nature and functions

Bockaert, J., Roussignol, G., Bécamel, C., Gavarini, S., Joubert, L., Dumuis, A., Fagni, L., & Marin, P. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320851 · Cited by 105 · see citing works

Coordination of Synaptic Adhesion with Dendritic Spine Remodeling by AF-6 and Kalirin-7

Xie, Z., Photowala, H., Cahill, M. E., Srivastava, D. P., Woolfrey, K. M., Shum, C. Y., Huganir, R. L., & Penzes, P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1170-08.2008 · Cited by 96 · see citing works

RAMPs: the past, present and future

Parameswaran, N., & Spielman, W. S. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.09.006 · Cited by 94 · see citing works

Transmission disequilibrium studies of the serotonin 5‐HT2A receptor gene (HTR2A) in autism

Veenstra-VanderWeele, J. M., Kim, S., Lord, C., Yeung-Courchesne, R., Akshoomoff, N., LEVENTHAL, B. L., Courchesne, E., & Cook, E. H. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10192 · Cited by 92 · see citing works

5-Hydroxytryptamine2A (5-HT2A) receptor desensitization can occur without down-regulation.

Roth, B. L., Pälvimäki, E.-P., Berry, S., Khan, N., Sachs, N. A., Uluer, A., & Choudhary, M. S. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12228-3 · Cited by 89 · see citing works

The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro

Xia, Z., Hufeisen, S. J., Gray, J. A., & Roth, B. L. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00589-x · Cited by 87 · see citing works

GABAB Receptor Association with the PDZ Scaffold Mupp1 Alters Receptor Stability and Function

Balasubramanian, S., Fam, S. R., & Hall, R. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607695200 · Cited by 82 · see citing works

Physiological and therapeutic relevance of constitutive activity of 5-HT2A and 5-HT2C receptors for the treatment of depression

BERG, K., Harvey, J., Spampinato, U., & Clarke, W. P. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00914-x · Cited by 81 · see citing works

Dopamine Depletion of the Prefrontal Cortex Induces Dendritic Spine Loss: Reversal by Atypical Antipsychotic Drug Treatment

Wang, H.-D., & Deutch, A. Y. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301521 · Cited by 80 · see citing works

The PDZ Protein Mupp1 Promotes Gi Coupling and Signaling of the Mt1 Melatonin Receptor

Guillaume, J., Daulat, A. M., Maurice, P., Levoye, A., Migaud, M., Brydon, L., Malpaux, B., Borg‐Capra, C., & Jockers, R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802069200 · Cited by 77 · see citing works

The Promnesic Effect of G-protein-Coupled 5-HT4 Receptors Activation Is Mediated by a Potentiation of Learning-Induced Spine Growth in the Mouse Hippocampus

Restivo, L., Roman, F. S., Dumuis, A., Bockaert, J., Marchetti, E., & Ammassari‐Teule, M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301644 · Cited by 62 · see citing works

Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases

Allen, J., Yadav, P. N., & Roth, B. L. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.048 · Cited by 59 · see citing works

Regulation of synapse density by 5-HT2A receptor agonist and antagonist in the spinal cord of chicken embryo

Niitsu, Y., Hatnada, S., Hamaguchi, K., Mikuni, M., & Okado, N. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11805-7 · Cited by 41 · see citing works

Colocalisation of serotonin2A receptors with the glutamate receptor subunits NR1 and GluR2 in the dentate gyrus: An ultrastructural study of a modulatory role

Peddie, C. J., Davies, H. A., Colyer, F. M., Stewart, M. G., & Rodríguez, J. J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.03.003 · Cited by 39 · see citing works

The neuronal RhoA GEF, Tech, interacts with the synaptic multi‐PDZ‐domain‐containing protein, MUPP1

Estévez, M. A., Henderson, J. A., Ahn, D., Zhu, X., Poschmann, G., Lübbert, H., Marx, R., & Baraban, J. M. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05472.x · Cited by 38 · see citing works

Chapter 11 Modification of dendritic development

Feria‐Velasco, A., del Angel, A. R., & González‐Burgos, I. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36013-8 · Cited by 30 · see citing works

Psychedelics promote structural and functional neural plasticity

Ly, C., Greb, A. C., Cameron, L. P., Wong, J. M., Barragan, E. V., Wilson, P. C., Burbach, K. F., Soltanzadeh Zarandi, S., Sood, A., Paddy, M. R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.022 · Cited by 1,207 · see citing works

Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

Bogenschutz, M. P., Forcehimes, A. A., Pommy, J. A., Wilcox, C. E., Barbosa, P., & Strassman, R. J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114565144 · Cited by 1,151 · see citing works

The neurobiology of psychedelic drugs: implications for the treatment of mood disorders

Vollenweider, F. X., & Kometer, M. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2884 · Cited by 723 · see citing works

Serotonin and brain function: a tale of two receptors

Carhart-Harris, R., & Nutt, D. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725915 · Cited by 739 · see citing works

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

Shao, L.-X., Liao, C., Gregg, I., Davoudian, P. A., Savalia, N. K., Delagarza, K., & Kwan, A. C. (2021) · Neuron · doi:10.1016/j.neuron.2021.06.008 · Cited by 626 · see citing works

Dendritic Spines: The Locus of Structural and Functional Plasticity

Sala, C., & Segal, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00012.2013 · Cited by 465 · see citing works

Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression

Kraus, C., Castrén, E., Kasper, S., & Lanzenberger, R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.007 · Cited by 457 · see citing works

Serotonin in the Modulation of Neural Plasticity and Networks: Implications for Neurodevelopmental Disorders

Lesch, K.-P., & Waider, J. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.013 · Cited by 435 · see citing works

The role of serotonin 5-HT2A receptors in memory and cognition

Zhang, G., & Stackman, R. W. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00225 · Cited by 386 · see citing works

Regulation of GPCR activity, trafficking and localization by GPCR‐interacting proteins

Magalhães, A. C., Dunn, H. A., & Ferguson, S. S. G. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01552.x · Cited by 352 · see citing works

The neural basis of psychedelic action

Kwan, A. C., Olson, D. E., Preller, K. H., & Roth, B. L. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01177-4 · Cited by 312 · see citing works

Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species

Halberstadt, A. L., Chatha, M., Klein, A. K., Wallach, J., & Brandt, S. D. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107933 · Cited by 278 · see citing works

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

Barnes, N. M., Ahern, G. P., Bécamel, C., Bockaert, J., Camilleri, M., Chaumont‐Dubel, S., Claeysen, S., Cunningham, K. A., Fone, K. C. F., Gershon, M. D., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.118.015552 · Cited by 264 · see citing works

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

Mason, N. L., Kuypers, K. P. C., Müller, F., Reckweg, J., Tse, D. H. Y., Toennes, S. W., Hutten, N. R. P. W., Jansen, J. F. A., Stiers, P., Feilding, A., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0718-8 · Cited by 258 · see citing works

Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works

Classic hallucinogens in the treatment of addictions

Bogenschutz, M. P., & Johnson, M. W. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.002 · Cited by 226 · see citing works

Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice

de la Fuente Revenga, M., Zhu, B., Guevara, C. A., Naler, L. B., Saunders, J. M., Zhou, Z., Toneatti, R., Sierra, S., Wolstenholme, J. T., Beardsley, P. M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109836 · Cited by 224 · see citing works

The Relationship between PSD-95 Clustering and Spine Stability <i>In Vivo</i>

Cane, M., Maco, B., Knott, G., & Holtmaat, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3353-13.2014 · Cited by 216 · see citing works

A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain

Raval, N. R., Johansen, A., Donovan, L. L., Ros, N. F., Ozenne, B., Hansen, H. D., & Knudsen, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020835 · Cited by 200 · see citing works

The promises and perils of psychedelic pharmacology for psychiatry

McClure‐Begley, T. D., & Roth, B. L. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00421-7 · Cited by 198 · see citing works

Role of PDZ Proteins in Regulating Trafficking, Signaling, and Function of GPCRs: Means, Motif, and Opportunity

Romero, G. G., von Zastrow, M., & Friedman, P. A. (2011) · Advances in pharmacology · doi:10.1016/b978-0-12-385952-5.00003-8 · Cited by 172 · see citing works

Pivotal mental states

Brouwer, A., & Carhart-Harris, R. L. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120959637 · Cited by 159 · see citing works

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works

Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits

Jitsuki, S., Takemoto, K., Kawasaki, T., Tada, H., Takahashi, A., Bécamel, C., Sano, A., Yuzaki, M., Zukin, R. S., Ziff, E. B., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.016 · Cited by 145 · see citing works

Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

Dakic, V., Minardi Nascimento, J., Costa Sartore, R., Maciel, R. D. M., de Araujo, D. B., Ribeiro, S., Martins-de-Souza, D., & Rehen, S. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-12779-5 · Cited by 134 · see citing works

Insights into Rapid Modulation of Neuroplasticity by Brain Estrogens

Srivastava, D. P., Woolfrey, K. M., & Penzes, P. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005272 · Cited by 138 · see citing works

Serotonergic signaling: multiple effectors and pleiotropic effects

Masson, J., Emerit, M. B., Hamon, M., & Darmon, M. C. (2012) · Wiley Interdisciplinary Reviews Membrane Transport and Signalling · doi:10.1002/wmts.50 · Cited by 132 · see citing works

Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity

Olson, D. E. (2022) · Biochemistry · doi:10.1021/acs.biochem.1c00812 · Cited by 135 · see citing works

Therapeutic mechanisms of classic hallucinogens in the treatment of addictions: from indirect evidence to testable hypotheses

Bogenschutz, M. P., & Pommy, J. M. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1376 · Cited by 125 · see citing works

Cortical reorganization after spinal cord injury: Always for good?

Moxon, K. A., Oliviero, A., Aguilar, J., & Foffani, G. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.056 · Cited by 123 · see citing works

Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress

Maras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118 · see citing works

Translating the N-methyl-d-aspartate receptor antagonist model of schizophrenia to treatments for cognitive impairment in schizophrenia

Meltzer, H. Y., Rajagopal, L., Huang, M., Oyamada, Y., Kwon, S., & Horiguchi, M. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000928 · Cited by 114 · see citing works

PDZ Protein Regulation of G Protein–Coupled Receptor Trafficking and Signaling Pathways

Dunn, H. A., & Ferguson, S. S. G. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.098509 · Cited by 108 · see citing works

Canalization and plasticity in psychopathology

Carhart-Harris, R. L., Chandaria, S., Erritzøe, D., Gazzaley, A. H., Girn, M., Kettner, H., Mediano, P. A. M., Nutt, D. J., Rosas, F. E., Roseman, L., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109398 · Cited by 103 · see citing works

Estrogen Receptor β Activity Modulates Synaptic Signaling and Structure

Srivastava, D. P., Woolfrey, K. M., Liu, F., Brandon, N. J., & Penzes, P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3264-10.2010 · Cited by 102 · see citing works

Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors

Shao, L.-X., Liao, C., Davoudian, P. A., Savalia, N. K., Jiang, Q., Wojtasiewicz, C., Tan, D., Nothnagel, J. D., Liu, R., Woodburn, S. C., et al. (2025) · Nature · doi:10.1038/s41586-025-08813-6 · Cited by 110 · see citing works

Development of a Psychotherapeutic Model for Psilocybin-Assisted Treatment of Alcoholism

Bogenschutz, M. P., & Forcehimes, A. A. (2016) · Journal of Humanistic Psychology · doi:10.1177/0022167816673493 · Cited by 98 · see citing works

Regulation of the Actin Cytoskeleton in Dendritic Spines

Penzes, P., & Rafalovich, I. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_4 · Cited by 94 · see citing works

Beyond the 5-HT2AReceptor: Classic and Nonclassic Targets in Psychedelic Drug Action

Cameron, L. P., Benetatos, J., Lewis, V., Bonniwell, E. M., Jaster, A. M., Moliner, R., Ċastrén, E., McCorvy, J. D., Palner, M., & Aguilar‐Valles, A. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1384-23.2023 · Cited by 93 · see citing works

Modulatory effects of cannabinoids on brain neurotransmission

Cohen, K., Weizman, A., & Weinstein, A. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14407 · Cited by 92 · see citing works

Assessing the risk–benefit profile of classical psychedelics: a clinical review of second-wave psychedelic research

Bender, D., & Hellerstein, D. J. (2022) · Psychopharmacology · doi:10.1007/s00213-021-06049-6 · Cited by 88 · see citing works

Psychedelics and Neural Plasticity: Therapeutic Implications

Grieco, S. F., Castrén, E., Knudsen, G. M., Kwan, A. C., Olson, D. E., Zuo, Y., Holmes, T. C., & Xu, X. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.1121-22.2022 · Cited by 82 · see citing works

An Autism-Associated Variant of Epac2 Reveals a Role for Ras/Epac2 Signaling in Controlling Basal Dendrite Maintenance in Mice

Srivastava, D. P., Woolfrey, K. M., Jones, K. A., Anderson, C. T., Smith, K. R., Russell, T. A., Lee, H., Yasvoina, M. V., Wokosin, D. L., Özdi̇nler, P. H., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001350 · Cited by 85 · see citing works

Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub

Blizinsky, K. D., Diaz-Castro, B., Forrest, M. P., Schürmann, B., Bach, A. P., Martin-de-Saavedra, M. D., Wang, L., Csernansky, J. G., Duan, J., & Penzes, P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607014113 · Cited by 76 · see citing works

From psychiatry to neurology: Psychedelics as prospective therapeutics for neurodegenerative disorders

Kozłowska, U., Nichols, C. D., Wiatr, K., & Figiel, M. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15509 · Cited by 80 · see citing works

5-HT2A receptors: Pharmacology and functional selectivity

Cummins, B. R., Billac, G. B., Nichols, D. E., & Nichols, C. D. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100059 · Cited by 79 · see citing works

Serotonin 2A Receptor (5-HT 2A R) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants

Duan, W., Cao, D., Wang, S., & Cheng, J. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00375 · Cited by 79 · see citing works

Review: Disruption of the Postsynaptic Density in Alzheimer’s Disease and Other Neurodegenerative Dementias

Gong, Y., & Lippa, C. F. (2010) · American Journal of Alzheimer's Disease &amp; Other Dementias® · doi:10.1177/1533317510382893 · Cited by 76 · see citing works

Control of dendritic spine morphological and functional plasticity by small GTPases.

Woolfrey, K. M., & Srivastava, D. P. (2016) · Neural Plasticity · doi:10.1155/2016/3025948 · Cited by 76 · see citing works

Serotonylation and Transamidation of Other Monoamines

Muma, N. A., & Mi, Z. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn500329r · Cited by 75 · see citing works

Pro-psychotic effects of synthetic cannabinoids: interactions with central dopamine, serotonin, and glutamate systems

Fantegrossi, W. E., Wilson, C. D., & Berquist, M. D. (2018) · Drug Metabolism Reviews · doi:10.1080/03602532.2018.1428343 · Cited by 73 · see citing works

Therapeutic mechanisms of psychedelics and entactogens

Heifets, B. D., & Olson, D. E. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01666-5 · Cited by 67 · see citing works

Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses

Berthoux, C., Barre, A., Bockaert, J., Marin, P., & Bécamel, C. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy064 · Cited by 68 · see citing works

Analysis of Dendritic Spine Morphology in Cultured CNS Neurons

Srivastava, D. P., Woolfrey, K. M., & Penzes, P. (2011) · Journal of Visualized Experiments · doi:10.3791/2794 · Cited by 67 · see citing works

Disrupting 5-HT2A Receptor/PDZ Protein Interactions Reduces Hyperalgesia and Enhances SSRI Efficacy in Neuropathic Pain

Pichon, X., Wattiez, A., Bécamel, C., Ehrlich, I., Bockaert, J., Eschalier, A., Marin, P., & Courteix, C. (2010) · Molecular Therapy · doi:10.1038/mt.2010.101 · Cited by 66 · see citing works

The polypharmacology of psychedelics reveals multiple targets for potential therapeutics

Jain, M. K., Gumpper, R. H., Slocum, S. T., Schmitz, G. P., Madsen, J. S., Tummino, T. A., Suomivuori, C., Huang, X.-P., Shub, L., DiBerto, J. F., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.06.012 · Cited by 66 · see citing works

Irving Page Lecture: 5-HT2A serotonin receptor biology: Interacting proteins, kinases and paradoxical regulation

Roth, B. L. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.012 · Cited by 66 · see citing works

Psychedelic‐inspired approaches for treating neurodegenerative disorders

Saeger, H. N., & Olson, D. E. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15544 · Cited by 65 · see citing works

Psychedelics as a Treatment for Alzheimer’s Disease Dementia

Jones, S. V., & O’Kelly, A. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00034 · Cited by 62 · see citing works

Molecular insights into psychedelic drug action

Slocum, S. T., DiBerto, J. F., & Roth, B. L. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15540 · Cited by 56 · see citing works

Platelets mediate protective neuroinflammation and promote neuronal plasticity at the site of neuronal injury

Dukhinova, M., Kuznetsova, I. S., Kopeikina, E., Veniaminova, E. A., Yung, A. W. Y., Veremeyko, T., Levchuk, K., Barteneva, N. S., Wing-Ho, K. K., Yung, W., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.009 · Cited by 60 · see citing works

5-HT2AReceptor-Induced Morphological Reorganization of PKCγ-Expressing Interneurons Gates Inflammatory Mechanical Allodynia in Rat

Alba‐Delgado, C., Mountadem, S., Mermet-Joret, N., Monconduit, L., Dallel, R., Artola, A., & Antri, M. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1294-18.2018 · Cited by 60 · see citing works

Regulating Prefrontal Cortex Activation: An Emerging Role for the 5-HT2A Serotonin Receptor in the Modulation of Emotion-Based Actions?

Aznar, S., & Klein, A. B. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8472-0 · Cited by 58 · see citing works

Phosphatidic acid in neuronal development: A node for membrane and cytoskeleton rearrangements

Ammar, M.-R., Kassas, N., Bader, M. F., & Vitale, N. (2014) · Biochimie · doi:10.1016/j.biochi.2014.07.026 · Cited by 58 · see citing works

5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice

Jefferson, S. J., Gregg, I., Dibbs, M., Liao, C., Wu, H., Davoudian, P. A., Woodburn, S. C., Wehrle, P. H., Sprouse, J. S., Sherwood, A. M., et al. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01572-w · Cited by 56 · see citing works

Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5‐HT2A) receptor activity via ERK1/2 signaling

Franklin, J. M., & Carrasco, G. A. (2012) · Synapse · doi:10.1002/syn.21626 · Cited by 56 · see citing works

Psychedelics as Transformative Therapeutics

Roth, B. L., & Gumpper, R. H. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230172 · Cited by 54 · see citing works

Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex

Ogelman, R., Wulschner, L. E. G., Hoelscher, V. M., Hwang, I.-W., Chang, V. N., & Oh, W. C. (2024) · Nature Communications · doi:10.1038/s41467-024-45734-w · Cited by 54 · see citing works

Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats

Horsley, R. R., Páleníček, T., Kolin, J., & Valeš, K. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000394 · Cited by 52 · see citing works

Sex-specific effects of psychedelic drug exposure on central amygdala reactivity and behavioral responding

Effinger, D. P., Quadir, S. G., Ramage, M. C., Cone, M. G., & Herman, M. A. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02414-5 · Cited by 50 · see citing works

Lysergic acid diethylamide: a drug of ‘use’?

Das, S., Barnwal, P., Ramasamy, A., Sen, S., & Mondal, S. (2016) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316640440 · Cited by 50 · see citing works

Epac2-mediated dendritic spine remodeling: Implications for disease

Penzes, P., Woolfrey, K. M., & Srivastava, D. P. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.008 · Cited by 47 · see citing works

Role of G Protein-Coupled Receptors in the Regulation of Structural Plasticity and Cognitive Function

Leung, C., & Wong, Y. (2017) · Molecules · doi:10.3390/molecules22071239 · Cited by 48 · see citing works

KALRN: A central regulator of synaptic function and synaptopathies

Parnell, E., Shapiro, L. P., Voorn, R. A., Forrest, M. P., Jalloul, H. A., Loizzo, D. D., & Penzes, P. (2020) · Gene · doi:10.1016/j.gene.2020.145306 · Cited by 47 · see citing works

The impact of insulin on the serotonergic system and consequences on diabetes‐associated mood disorders

Martin, H., Bullich, S., Guiard, B. P., & Fioramonti, X. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12928 · Cited by 48 · see citing works

Rapid Estradiol Modulation of Neuronal Connectivity and Its Implications for Disease

Srivastava, D. P., & Penzes, P. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00077 · Cited by 44 · see citing works

Kalrnplays key roles within and outside of the nervous system

Mandela, P., Yankova, M. P., Conti, L. H., Ma, X., Grady, J., Eipper, B. A., & Mains, R. E. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-136 · Cited by 43 · see citing works

Receptor-stimulated transamidation induces activation of Rac1 and Cdc42 and the regulation of dendritic spines

Mi, Z., Si, T., Kapadia, K., Li, Q., & Muma, N. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.034 · Cited by 43 · see citing works

The structural diversity of psychedelic drug actions revealed

Gumpper, R. H., Jain, M. K., Kim, K., Sun, R., Sun, N., Xu, Z., DiBerto, J. F., Krumm, B. E., Kapolka, N. J., Kanıskan, H. Ü., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57956-7 · Cited by 44 · see citing works

Abnormal kalirin signaling in neuropsychiatric disorders

Remmers, C. L., Sweet, R. A., & Penzes, P. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.12.006 · Cited by 43 · see citing works

Effect of chemically synthesized psilocybin and psychedelic mushroom extract on molecular and metabolic profiles in mouse brain

Shahar, O., Botvinnik, A., Shwartz, A., Lerer, E., Golding, P., Buko, A., Hamid, E., Kahn, D., Guralnick, M., Blakolmer, K., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02477-w · Cited by 40 · see citing works

Tripping up addiction: the use of psychedelic drugs in the treatment of problematic drug and alcohol use

Morgan, C. J. A., McAndrew, A., Stevens, T., Nutt, D., & Lawn, W. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.10.009 · Cited by 42 · see citing works

Effects of antipsychotic drugs on neurites relevant to schizophrenia treatment

Huang, X., & Song, X. (2018) · Medicinal Research Reviews · doi:10.1002/med.21512 · Cited by 42 · see citing works

A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness

Russell, T. A., Blizinsky, K. D., Cobia, D. J., Cahill, M. E., Xie, Z., Sweet, R. A., Duan, J., Gejman, P. V., Wang, L., Csernansky, J. G., et al. (2014) · Nature Communications · doi:10.1038/ncomms5858 · Cited by 39 · see citing works

Catalysts for change: the cellular neurobiology of psychedelics

Banks, M. I., Zahid, Z., Jones, N., Sultan, Z. W., & Wenthur, C. J. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e20-05-0340 · Cited by 37 · see citing works

Two-Step Wiring Plasticity – A mechanism for estrogen-induced rewiring of cortical circuits

Srivastava, D. P. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.01.006 · Cited by 37 · see citing works

Kalirin Signaling: Implications for Synaptic Pathology

Penzes, P., & Remmers, C. L. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8223-z · Cited by 36 · see citing works

Orbitofrontal cortex 5-HT2A receptor mediates chronic stress-induced depressive-like behaviors and alterations of spine density and Kalirin7

Xu, C., Ma, X.-M., Chen, H.-B., Zhou, M.-H., Qiao, H., & An, S.-C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.020 · Cited by 34 · see citing works

Regulating Rac in the Nervous System: Molecular Function and Disease Implication of Rac GEFs and GAPs

Bai, Y., Xiang, X., Liang, C., & Shi, L. (2015) · BioMed Research International · doi:10.1155/2015/632450 · Cited by 40 · see citing works

Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl

Ma, X., Miller, M. B., Vishwanatha, K. S., Gross, M. J., Wang, Y., Abbott, T. B., Lam, T. T., Mains, R. E., & Eipper, B. A. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-04-0215 · Cited by 35 · see citing works

Physical activity promotes brain development through serotonin during early childhood

Jing, J.-Q., Jia, S.-J., & Yang, C.-J. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.07.015 · Cited by 34 · see citing works

Hippocampal phenotypes in kalirin-deficient mice

Xie, Z., Cahill, M. E., Radulovic, J., Wang, J., Campbell, S. L., Miller, C. A., Sweatt, J. D., & Penzes, P. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.005 · Cited by 34 · see citing works

PDZK1/NHERF3 Differentially Regulates Corticotropin-releasing Factor Receptor 1 and Serotonin 2A Receptor Signaling and Endocytosis

Walther, C., Caetano, F. A., Dunn, H. A., & Ferguson, S. S. G. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2014.12.019 · Cited by 33 · see citing works

Comparison of LPS and MS-induced depressive mouse model: behavior, inflammation and biochemical changes

Yu, X., Yao, H., Zhang, X., Liu, L., Liu, S., & Dong, Y. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04233-2 · Cited by 33 · see citing works

The role of serotonin neurotransmission in rapid antidepressant actions

Pehrson, A. L., Roberts, D., Khawaja, A., & McNair, R. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06098-5 · Cited by 33 · see citing works

The Effects of Psychedelics on Neuronal Physiology

Hatzipantelis, C. J., & Olson, D. E. (2023) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042022-020923 · Cited by 32 · see citing works

Preclinical perspectives on the mechanisms underlying the therapeutic actions of psilocybin in psychiatric disorders

Wulff, A. B., Nichols, C. D., & Thompson, S. M. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109504 · Cited by 34 · see citing works

Subtype specific roles of serotonin receptors in the spine formation of cortical neurons in vitro

Yoshida, H., Kanamaru, C., Ohtani, A., Li, F., Senzaki, K., & Shiga, T. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.07.1824 · Cited by 33 · see citing works

Serotonergic Psychedelics in Neural Plasticity

Łukasiewicz, K., Baker, J. J., Zuo, Y., & Lu, J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.748359 · Cited by 31 · see citing works

Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders

Wang, X., Liu, D., Wei, F., Li, Y., Wang, X., Li, L., Wang, G., Zhang, S., & Zhang, L. (2020) · Neural Plasticity · doi:10.1155/2020/8894372 · Cited by 30 · see citing works

REGULATION OF DENDRITIC SPINES BY 5-HT2A RECEPTOR SIGNALING PATHWAYS

Mi, Z. (2015) · KU ScholarWorks (The University of Kansas)

Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT2A receptors

Roppongi, R. T., Kojima, N., Hanamura, K., Yamazaki, H., & Shirao, T. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.04.061 · Cited by 14 · see citing works

Serotonin 5‐ HT 7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons

Speranza, L., Labus, J., Volpicelli, F., Guseva, D., Lacivita, E., Leopoldo, M., Bellenchi, G. C., di Porzio, U., Bijata, M., Perrone‐Capano, C., et al. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13962 · Cited by 91 · see citing works

Subtype specific roles of serotonin receptors in the spine formation of cortical neurons in vitro

Yoshida, H., Kanamaru, C., Ohtani, A., Li, F., Senzaki, K., & Shiga, T. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.07.1824 · Cited by 33 · see citing works

Regulation of dendrite formation of Purkinje cells by serotonin through serotonin1A and serotonin2A receptors in culture

Kondoh, M., Shiga, T., & Okado, N. (2003) · Neuroscience Research · doi:10.1016/j.neures.2003.10.001 · Cited by 48 · see citing works