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Oxidative stress in the hippocampus, anxiety-like behavior and decreased locomotory and exploratory activity of adult rats: Effects of sub acute vitamin A supplementation at therapeutic doses
Abstract
Vitamin A participates in the maintenance of normal hippocampal function during embryonic and postnatal stages of the vertebrate life. Some works demonstrated that vitamin A metabolites impair learning and induce a depression-like behavior in mice, among other effects. Since vitamin A has prooxidant effects on other experimental models, we decided to investigate whether vitamin A can induce oxidative stress in the adult rat hippocampus. We analyzed the sub acute effects of therapeutic (1000 and 2500 I.U./kg) or excessive (4500 and 9000 I.U./kg) vitamin A doses on the hippocampal redox state, as well as on levels of anxiety, and locomotory and exploratory activity. Vitamin A supplementation induced lipid peroxidation, protein carbonylation, and oxidation of the protein thiol content in the rat hippocampus in all periods analyzed. Increased superoxide dismutase (SOD) activity and decreased catalase (CAT) activity were also observed, which gives rise to an imbalance in the principal cellular enzymatic antioxidant system. Then, our results show, for the first time, that vitamin A induced oxidative stress in the adult rat hippocampus, is anxiogenic, and decreases locomotion in and exploration of an open field.
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“Oxidative unbalance was also demonstrated in anxiety models by mainly pointing out the presence of increased lipid peroxidation, protein carboxylation, and protein thiol oxidation and decreased vitamin E levels [109, 173].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [109]
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Metadata
- Authors
- DEOLIVEIRA, M., SILVESTRIN, R., MELLOESOUZA, T., & MOREIRA, J.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- ORCID
- SILVESTRIN, R
- Venue
- NeuroToxicology
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 28
- Issue
- 6
- Pages
- 1191-1199
- ISSN
- 0161-813X (ISSN-L)
- OpenAlex
- W2081000970
- Cited by
- 130
- References
- 66
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 9 · 2018: 12 · 2017: 2 · 2016: 5 · 2015: 9 · 2014: 11 · 2013: 7 · 2012: 9
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroToxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Federal do Rio Grande do Sul
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- vitamin A, oxidative stress, hippocampus, anxiety-like behavior, locomotor activity, exploratory activity, lipid peroxidation, protein carbonylation, thiol oxidation, superoxide dismutase, catalase, antioxidant enzymes, redox state, pro-oxidant activity
- MeSH terms
- Aging, Animals, Anxiety, Behavior, Animal, Catalase, Dose-Response Relationship, Drug, Exploratory Behavior, Glutathione Peroxidase, Hippocampus, Locomotion, Male, Oxidation-Reduction, Sulfhydryl Compounds, Superoxide Dismutase, Vitamin A, Vitamins, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Protein Carbonylation, Rats
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