Cited by 130Antioxidant Activity and Oxidative StressTrace Elements in HealthRedox biology and oxidative stress

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Oxidative stress in the hippocampus, anxiety-like behavior and decreased locomotory and exploratory activity of adult rats: Effects of sub acute vitamin A supplementation at therapeutic doses

DEOLIVEIRA, M, SILVESTRIN, R, MELLOESOUZA, T, MOREIRA, J·2007·NeuroToxicology

DOI 10.1016/j.neuro.2007.07.008

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Abstract

Vitamin A participates in the maintenance of normal hippocampal function during embryonic and postnatal stages of the vertebrate life. Some works demonstrated that vitamin A metabolites impair learning and induce a depression-like behavior in mice, among other effects. Since vitamin A has prooxidant effects on other experimental models, we decided to investigate whether vitamin A can induce oxidative stress in the adult rat hippocampus. We analyzed the sub acute effects of therapeutic (1000 and 2500 I.U./kg) or excessive (4500 and 9000 I.U./kg) vitamin A doses on the hippocampal redox state, as well as on levels of anxiety, and locomotory and exploratory activity. Vitamin A supplementation induced lipid peroxidation, protein carbonylation, and oxidation of the protein thiol content in the rat hippocampus in all periods analyzed. Increased superoxide dismutase (SOD) activity and decreased catalase (CAT) activity were also observed, which gives rise to an imbalance in the principal cellular enzymatic antioxidant system. Then, our results show, for the first time, that vitamin A induced oxidative stress in the adult rat hippocampus, is anxiogenic, and decreases locomotion in and exploration of an open field.

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Authors: DEOLIVEIRA, M., SILVESTRIN, R., MELLOESOUZA, T., & MOREIRA, J.
Affiliations: Universidade Federal do Rio Grande do Sul (BR)
ORCID: SILVESTRIN, R
Venue: NeuroToxicology
Publisher: Elsevier BV
Published: 2007-11
Volume: 28
Issue: 6
Pages: 1191-1199
ISSN: 0161-813X (ISSN-L)
DOI: 10.1016/j.neuro.2007.07.008
OpenAlex: W2081000970
Cited by: 130
References: 66
Citations by year: 2026: 3 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 9 · 2018: 12 · 2017: 2 · 2016: 5 · 2015: 9 · 2014: 11 · 2013: 7 · 2012: 9
FWCI: 6.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroToxicology (publishedVersion)
PubMed (publishedVersion)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico
Universidade Federal do Rio Grande do Sul
National Institutes of Health
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: vitamin A, oxidative stress, hippocampus, anxiety-like behavior, locomotor activity, exploratory activity, lipid peroxidation, protein carbonylation, thiol oxidation, superoxide dismutase, catalase, antioxidant enzymes, redox state, pro-oxidant activity
MeSH terms: Aging, Animals, Anxiety, Behavior, Animal, Catalase, Dose-Response Relationship, Drug, Exploratory Behavior, Glutathione Peroxidase, Hippocampus, Locomotion, Male, Oxidation-Reduction, Sulfhydryl Compounds, Superoxide Dismutase, Vitamin A, Vitamins, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Protein Carbonylation, Rats

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Oxidative stress in the hippocampus, anxiety-like behavior and decreased locomotory and exploratory activity of adult rats: Effects of sub acute vitamin A supplementation at therapeutic doses

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