Magnetization transfer imaging of gray and white matter in mild cognitive impairment and Alzheimer's disease
Abstract
Objective To assess whether structural brain damage as detected by magnetization transfer imaging (MTI) in Alzheimer's disease (AD) and mild cognitive impairment (MCI) is located in the gray matter (GM) and/or the white matter (WM). Methods Fifty-five AD patients, 19 MCI patients and 43 subjects with normal cognitive function participated in this study. GM and WM segmentations were generated from dual fast spin-echo MR images. These masks were co-registrated to MT images for volumetric MTI-analysis of the GM and WM. Results AD patients had a lower GM volume than controls. Both MCI and AD patients had more structural brain damage in both GM and WM than subjects with normal cognition. Cerebral lesion load in both GM and WM was associated with the degree of cognitive impairment. Conclusion Using MTI, structural brain changes that are related to cognitive impairment could be demonstrated in both GM and WM of patients with AD and MCI. These results suggest that cerebral changes are present in GM and WM even before patients are clinically demented.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Magnetisation transfer ratio has been studied in clinical Alzheimer's disease.
“Magnetisation transfer ratio has been studied in clinical Alzheimer's disease (Hentschel et al., 2004, van Es et al., 2006).”
From In vivo imaging of tau pathology using multi-parametric quantitative MRI (2015) · cites this paper as van Es et al., 2006
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Cerebral microvascular pathology in aging and Alzheimer's disease
Farkas, E., & Luiten, P. G. M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00068-x · Cited by 1,102 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Magnetic Resonance Imaging of Myelin
Laule, C., Vavasour, I. M., Kolind, S. H., Li, D. K. B., Traboulsee, T. L., Moore, G. R. W., & MacKay, A. L. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.004 · Cited by 334 · see citing works
Jacobs, H. I. L., Van Boxtel, M. P. J., Jolles, J., Verhey, F. R. J., & Uylings, H. B. M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.009 · Cited by 293 · see citing works
In vivo imaging of tau pathology using multi-parametric quantitative MRI
Wells, J. A., O'Callaghan, J. M., Holmes, H. E., Powell, N. M., Johnson, R. A., Siow, B., Torrealdea, F., Ismail, O., Walker-Samuel, S., Golay, X., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.02.023 · Cited by 93 · see citing works
- Authors
- van Es, A. C. G. M., van der Flier, W. M., Admiraal-Behloul, F., Olofsen, H., Bollen, E. L. E. M., Middelkoop, H. A. M., Weverling-Rijnsburger, A. W. E., Westendorp, R. G. J., & van Buchem, M. A.
- Affiliations
- Leiden University Medical Center (NL)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 27
- Issue
- 12
- Pages
- 1757-1762
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2027711842
- Cited by
- 33
- References
- 2
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2015: 3 · 2013: 2 · 2012: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- magnetization transfer imaging, Alzheimer's disease, mild cognitive impairment, gray matter, white matter, structural brain damage, gray matter volume, lesion load, cognitive impairment, preclinical dementia
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Brain, Cerebral Cortex, Cognition Disorders, Female, Humans, Image Enhancement, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
