The DOI matches its Crossref record; 84 of the 88 references it cites were found in a registry or an index.
Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction
Open accessAbstract
The expression of IL-1 is elevated in the CNS in diverse neurodegenerative disorders, including Alzheimer's disease. The hypothesis was tested that IL-1 beta renders neurons vulnerable to degeneration by interfering with BDNF-induced neuroprotection. In trophic support-deprived neurons, IL-1 beta compromised the PI3-K/Akt pathway-mediated protection by BDNF and suppressed Akt activation. The effect was specific as in addition to Akt, the activation of MAPK/ERK, but not PLC gamma, was decreased. Activation of CREB, a target of these signaling pathways, was severely depressed by IL-1 beta. As the cytokine did not influence TrkB receptor and PLC gamma activation, IL-1 beta might have interfered with BDNF signaling at the docking step conveying activation to the PI3-K/Akt and Ras/MAPK pathways. Indeed, IL-1 beta suppressed the activation of the respective scaffolding proteins IRS-1 and Shc; this effect might involve ceramide generation. IL-1-induced interference with BDNF neuroprotection and signal transduction was corrected, in part, by ceramide production inhibitors and mimicked by the cell-permeable C2-ceramide. These results suggest that IL-1 beta places neurons at risk by interfering with BDNF signaling involving a ceramide-associated mechanism.
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“IFN-alpha administration has also been found to decrease systemic BDNF levels in humans (Kenis et al., 2010, Lotrich et al., 2013) (see Figure 1), as can other inflammatory cytokines and LPS injections (Tong et al., 2008, Cortese et al., 2011) (Guan and Fang, 2006).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Tong et al., 2008
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Cites
2 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769
RetractedVenters, H., Tang, Q., Liu, Q., VanHoy, R. W., Dantzer, R., & Kelley, K. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9879 · Cited by 187
RetractedAmyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537 · cited 2×
“BDNF activates not only the PI3-K/Akt, but also other major signaling pathways [28].”
BackgroundBonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,908
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
Lue, L.-F., Kuo, Y.-M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., & Rogers, J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65184-x · Cited by 1,530
Research works printed but not linked: 1
- Nicoll, 2000, Association of interleukin-1 gene polymorphisms with Alzheimer's disease, Ann. Neurol., 47, 365, 10.1002/1531-8249(200003)47:3<365::AID-ANA13>3.0.CO;2-G · DOI
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Hayley, S. P., & Litteljohn, D. (2013) · Wiley eBooks · doi:10.1002/9781118314814.ch20 · Cited by 1
Mickael, M., Kubick, N., Horbańczuk, J. O., Religa, P., & Sacharczuk, M. (2023) · Preprints.org · doi:10.20944/preprints202310.0251.v1
Ramírez-Olvera, A., Pérez‐Martínez, L., & Pedraza‐Alva, G. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4824537 · Cited by 1
Jackman, N. A. (2013) · OpenCommons at University of Connecticut (University of Connecticut)
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Das, U. N. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch11
Gómez-Lázaro, E. (2014) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Cortese, G. P. (2013) · CU Scholar (University of Colorado Boulder)
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Roussas, A., Martinez, B. I., Addington, C. P., & Stabenfeldt, S. E. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-44996-8_7
Weber, M. D. (2015) · CU Scholar (University of Colorado Boulder)
O’Leary, J. D. (2017) · Cork Open Research Archive (University College Cork, Ireland)
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Menengi̇ç, K. N., Yeldan, İ., & Bahadır, F. E. (2023) · Fenerbahçe Üniversitesi Sağlık Bilimleri Dergisi · doi:10.56061/fbujohs.1168312
Kamel, A. S. E. D., Mohamed, M. M., & Zaki, H. F. (2024) · Research Square · doi:10.21203/rs.3.rs-4560073/v1
Xu, D., Liu, J., Meng, S., Sun, M., Chen, Y., & Hong, Y. N. (2024) · Figshare · doi:10.6084/m9.figshare.25980509
Xu, D., Liu, J., Meng, S., Sun, M., Chen, Y., & Hong, Y. N. (2024) · Figshare · doi:10.6084/m9.figshare.25980605
Xu, D., Liu, J., Meng, S., Sun, M., Chen, Y., & Hong, Y. N. (2024) · Figshare · doi:10.6084/m9.figshare.26729905
Wang, Y., Zhang, Y., Cui, Y., Zhu, J. K., Wang, C., Wang, S., Xiao, X., & Yang, L. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1711114
Zerin, S., Rahman, A. N., Hamiduzzaman, M., Asaduzzaman, M., Shahriar, M., Islam, M. R., & Nahar, Z. (2026) · Research Square · doi:10.21203/rs.3.rs-9633673/v1
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Tan, J., Cao, P., Pan, N., Fang, Z., Yang, F., & Yu, L. (2026) · Epilepsy Research · doi:10.1016/j.eplepsyres.2026.107909
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Metadata
- Authors
- Tong, L., Balazs, R., Soiampornkul, R., Thangnipon, W., & Cotman, C. W.
- Affiliations
- University of California, Irvine (US)
- Mahidol University (TH)
- Corresponding author
- Tong, Liqi
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 29
- Issue
- 9
- Pages
- 1380-1393
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC4052889
- OpenAlex
- W2015851283
- Cited by
- 222
- References
- 88
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 18 · 2023: 12 · 2022: 13 · 2021: 12 · 2020: 16 · 2019: 8 · 2018: 14 · 2017: 18 · 2016: 13 · 2015: 8 · 2014: 11 · 2013: 18 · 2012: 15
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P01AG000538)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- IL-1β, brain-derived neurotrophic factor, neuroprotection, PI3K/Akt signaling, ERK signaling, CREB activation, TrkB receptor, IRS-1, Shc, ceramide, neurodegeneration, Alzheimer's disease, neuroinflammation, signal transduction
- MeSH terms
- Animals, Cells, Cultured, Cerebral Cortex, Neurons, Signal Transduction, Apoptosis, Brain-Derived Neurotrophic Factor, Rats, Interleukin-1beta
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