Cotman, Carl W.

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G. (2003) · Science

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 4,064

Exercise: a behavioral intervention to enhance brain health and plasticity

Cotman, C. (2002) · Trends in Neurosciences

Neurogenesis and neuroplasticity mechanismsNerve injury and regeneration

Cited by 2,739

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 2,380

Exercise builds brain health: key roles of growth factor cascades and inflammation

Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 2,268

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Naj, A. C., Jun, G., Beecham, G. W., Wang, L.-S., Vardarajan, B. N., Buros, J., Gallins, P. J., Buxbaum, J. D., Jarvik, G. P., Crane, P. K., et al. (2011) · Nature Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,901

Exercise and brain neurotrophins

Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature

Nerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

Cited by 1,066

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

Burdick, D., Soreghan, B., Kwon, M., Kosmoski, J., Knauer, M., Henschen, A., Yates, J., Cotman, C., & Glabe, C. (1992) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,014

Neurobiology of exercise

Dishman, R. K., Berthoud, H., Booth, F. W., Cotman, C. W., Edgerton, V. R., Fleshner, M. R., Gandevia, S. C., Gomez‐Pinilla, F., Greenwood, B. N., Hillman, C. H., et al. (2006) · Obesity

Physical Activity and HealthNeurogenesis and neuroplasticity mechanisms

Cited by 958

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

Kayed, R., Head, E., Sarsoza, F., Saing, T., Cotman, C. W., Necula, M., Margol, L., Wu, J., Breydo, L., Thompson, J. L., et al. (2007) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 773

Emerging roles of oxidative stress in brain aging and Alzheimer's disease

Ionescu-Tucker, A., & Cotman, C. W. (2021) · Neurobiology of Aging

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 737

Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

Pike, C. J., Walencewicz‐Wasserman, A. J., Kosmoski, J., Cribbs, D. H., Glabe, C. G., & Cotman, C. W. (1995) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 699

Gene expression changes in the course of normal brain aging are sexually dimorphic

Berchtold, N. C., Cribbs, D. H., Coleman, P. D., Rogers, J., Head, E., Kim, R., Beach, T., Miller, C., Troncoso, J., Trojanowski, J. Q., et al. (2008) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 626

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Van Deerlin, V. M., Sleiman, P. M. A., Martinez-Lage, M., Chen-Plotkin, A., Wang, L.-S., Graff-Radford, N. R., Dickson, D. W., Rademakers, R., Boeve, B. F., Grossman, M., et al. (2010) · Nature Genetics

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 579

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

Rissman, R. A., Poon, W. W., Blurton-Jones, M., Oddo, S., Torp, R., Vitek, M. P., LaFerla, F. M., Rohn, T. T., & Cotman, C. W. (2004) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 543

Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonists

Harris, E. W., & Cotman, C. W. (1986) · Neuroscience Letters

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 540

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

Cribbs, D. H., Berchtold, N. C., Perreau, V., Coleman, P. D., Rogers, J., Tenner, A. J., & Cotman, C. W. (2012) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 499

Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus

Berchtold, N. C., Chinn, G., Chou, M., Kesslak, J. P., & Cotman, C. W. (2005) · Neuroscience

Nerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

Cited by 471

Antioxidants for Alzheimer Disease: A Randomized Clinical Trial With Cerebrospinal Fluid Biomarker Measures

Galasko, D. R., Peskind, E., Clark, C. M., Quinn, J. F., Ringman, J. M., Jicha, G. A., Cotman, C., Cottrell, B., Montine, T. J., Thomas, R. G., et al. (2012) · Archives of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 377

Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen

Brewer, G. J., & Cotman, C. W. (1989) · Brain Research

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 376

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

McQuade, A., Kang, Y. J., Hasselmann, J., Jairaman, A., Sotelo, A., Coburn, M., Shabestari, S. K., Chadarevian, J. P., Fote, G., Tu, C. H., et al. (2020) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 361

Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus

Oliff, H. S., Berchtold, N. C., Isackson, P., & Cotman, C. W. (1998) · Molecular Brain Research

Nerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

Cited by 361

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

Jiang, H., Burdick, D., Glabe, C. G., Cotman, C. W., & Tenner, A. J. (1994) · The Journal of Immunology

Alzheimer's disease research and treatmentsComplement system in diseases

Cited by 330

Estrogen and exercise interact to regulate brain‐derived neurotrophic factor mRNA and protein expression in the hippocampus

Berchtold, N. C., Kesslak, J. P., Pike, C. J., Adlard, P. A., & Cotman, C. W. (2001) · European Journal of Neuroscience

Nerve injury and regenerationEstrogen and related hormone effects

Cited by 329

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O’Leary, J. C., Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., et al. (2013) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsHeat shock proteins research

Cited by 322