Cited by 517Functional Brain Connectivity StudiesMind wandering and attentionNeural and Behavioral Psychology Studies

The DOI matches its Crossref record, with a small difference in title or year; 90 of the 91 references it cites were found in a registry or an index.

Age-related alterations in default mode network: Impact on working memory performance

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Abstract

The default mode network (DMN) is a set of functionally connected brain regions which shows deactivation (task-induced deactivation, TID) during a cognitive task. Evidence shows an age-related decline in task-load-related modulation of the activity within the DMN during cognitive tasks. However, the effect of age on the functional coupling within the DMN and their relation to cognitive performance has hitherto been unexplored. Using functional magnetic resonance imaging, we investigated functional connectivity within the DMN in older and younger subjects during a working memory task with increasing task load. Older adults showed decreased connectivity and ability to suppress low frequency oscillations of the DMN. Additionally, the strength of the functional coupling of posterior cingulate (pCC) with medial prefrontal cortex (PFC) correlated positively with performance and was lower in older adults. pCC was also negatively coupled with task-related regions, namely the dorsolateral PFC and cingulate regions. Our results show that in addition to changes in canonical task-related brain regions, normal aging is also associated with alterations in the activity and connectivity of brain regions within the DMN. These changes may be a reflection of a deficit in cognitive control associated with advancing age that results in deficient resource allocation to the task at hand.

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Crossref · 10.1016/j.neurobiolaging.2008.05.022

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Show all 91 references

Research works printed but not linked: 2

  1. Greicius, M.D., Supekar, K., Dougherty, R., 2007. Functional connectivity reflects structural connectivity in a human memory network. Proceedings of the Thirteenth Annual Meeting of the Organization for Human Brain Mapping (HBM’07), CD-ROM paper no. 336 TH-PM., 94 W-PM.
  2. Hugenschmidt, C.E., Peiffer, A.M., Casanova, R., Maldjian, J.A., Burdette, J.H., Hayasaka, S., Laurienti, P.J., 2007. Preservation of default mode functioning in healthy aging adults. Proceedings of the Thirteenth Annual Meeting of the Organization for Human Brain Mapping (HBM’07) CD-ROM paper no. 336 TH-PM., 49 TH-AM.

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Metadata

Authors
Sambataro, F., Murty, V. P., Callicott, J. H., Tan, H.-Y., Das, S., Weinberger, D. R., & Mattay, V. S.
Affiliations
National Institutes of Health (US)
Corresponding author
Mattay, Venkata S.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2010-05
Volume
31
Issue
5
Pages
839-852
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2047342826
Cited by
517
References
91
Citations by year
2026: 11 · 2025: 18 · 2024: 18 · 2023: 32 · 2022: 29 · 2021: 28 · 2020: 32 · 2019: 22 · 2018: 29 · 2017: 36 · 2016: 40 · 2015: 37 · 2014: 37 · 2013: 34 · 2012: 38
FWCI
12.58
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Institutional Research Information System (University of Udine) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Funders
National Institutes of Health (Z99 MH999999)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
default mode network, normal aging, working memory, functional connectivity, task-induced deactivation, posterior cingulate cortex, medial prefrontal cortex, cognitive control, workload, low-frequency oscillations, older adults
MeSH terms
Adult, Age Factors, Aged, Aged, 80 and over, Aging, Analysis of Variance, Brain Mapping, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Nerve Net, Neural Pathways, Neuropsychological Tests, Psychomotor Performance, Reaction Time, Chi-Square Distribution, Prefrontal Cortex

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